A5006140704- Diabetes and associated disorders
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- Diabetes Management and Research
- T-cell and B-cell Immunology
- Virus-based gene therapy research
Albert Einstein College of Medicine
2012-2019
Several β cell antigens recognized by T cells in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D) are also targets human disease. While numerous antigen-specific therapies prevent NOD mice, successful translation rodent findings to patients has been difficult. A leucocyte antigen (HLA)-transgenic incorporating cell-specific might provide a better platform for evaluating therapies. The ability study such is limited their low frequency peripheral blood and difficulty obtaining...
Abstract CD8+ T cells specific for islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) have been implicated in type 1 diabetes both humans and non-obese diabetic (NOD) mice, which IGRP206–214 are highly prevalent. We sought to manipulate these pathogenic by exploiting the ability of steady-state dendritic (DCs) present antigens a tolerogenic manner. The endocytic receptor DEC-205 was utilized deliver an mimotope DCs NOD impact this delivery on polyclonal population...
Type 1 diabetes is an autoimmune disease characterized by T cell responses to β Ags, including insulin. Investigations employing the NOD mouse model of have revealed essential role for cell-specific CD8(+) cells in pathogenic process. As specific Ags are also present patients, these reactivities potential serve as therapeutic targets or markers activity. mice transgenic human class I MHC molecules previously been employed identify epitopes having important relevance disease. However, most...
Adoptive cell immunotherapy for human diseases, including the use of T cells modified to express an anti-tumour T-cell receptor (TCR) or chimeric antigen receptor, is showing promise as effective treatment modality. Further advances would be accelerated by availability a mouse model that permit engineering protocols and proposed genetic modifications evaluated in vivo. NOD-scid IL2rγ(null) (NSG) mice accept engraftment mature cells; however, long-term evaluation transferred has been hampered...
Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. Multiple genetic loci contribute to susceptibility in humans, with most responsible locus being major histocompatibility complex (MHC). Certain MHC alleles are predisposing, including common HLA-A(∗)02:01. After MHC, conferring strongest T1D regulatory region insulin gene, and associated reduced thymic expression predisposing. Mice express two genes, Ins1 Ins2....
Abstract Dendritic cells (DCs) are crucial for the production of adaptive immune responses to disease-causing microbes. However, in steady state (i.e., absence an infection or when Ags experimentally delivered without a DC-activating adjuvant), DCs present T tolerogenic manner and important establishment peripheral tolerance. Delivery islet using Ag-linked Abs DC endocytic receptor CD205 has shown promise NOD mouse model type 1 diabetes (T1D). It is note, however, that all myeloid express...