A5019709859- Bone Metabolism and Diseases
- Extracellular vesicles in disease
- Bone health and osteoporosis research
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Adipose Tissue and Metabolism
- Advances in Cucurbitaceae Research
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Pharmacological Effects of Medicinal Plants
- T-cell and B-cell Immunology
- Angiogenesis and VEGF in Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Bone health and treatments
- Biomarkers in Disease Mechanisms
- Cancer-related molecular mechanisms research
- Leprosy Research and Treatment
- Computational Drug Discovery Methods
- Erythrocyte Function and Pathophysiology
- Hormonal and reproductive studies
- Nuclear Receptors and Signaling
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
Medical College of Wisconsin
2022-2024
Sunnybrook Health Science Centre
2024
University of Toronto
2024
Novel Health Strategies (United States)
2020-2023
Indira Gandhi Institute of Medical Sciences
2017-2023
Jawaharlal Nehru University
2014-2021
Central Drug Research Institute
2008-2020
All India Institute of Medical Sciences
1991-2020
Department of Biotechnology
2020
University of Lucknow
2020
Abstract SPHK1 (sphingosine kinase‐1) catalyzes the phosphorylation of sphingosine to sphingosine‐1‐phosphate (S1P), is found be highly expressed in solid tumors. Here, extracellular vesicles (EVs) are identified as key transporters tumor microenvironment. Consequently, SPHK1‐packaged EVs elevate S1P levels microenvironment, where appears an immunosuppressive agent. However, exact mechanism how mediates its effects cancer not understood. It investigated that can induce T cell exhaustion....
Abstract Lack of effective anti-metastatic drugs creates a major hurdle for metastatic lung cancer therapy. For successful treatment, there is strong need newer therapeutics with metastasis-inhibitory potential. In the present study, we determined and anti-angiogenic potential natural plant triterpenoid, Cucurbitacin B (CuB) against non-small cell (NSCLC) both in vitro vivo . CuB demonstrated anti-migratory anti-invasive ability NSCLC at nanomolar concentrations. also showed significant...
Type 2 diabetes is associated with increased fracture risk and delayed healing; the underlying mechanism, however, remains poorly understood. We systematically investigated skeletal pathology in leptin receptor-deficient diabetic mice on a C57BLKS background (db). Compared wild type (wt), db displayed reduced peak bone mass age-related trabecular cortical loss. Poor outcome contributed high-glucose- nonesterified fatty acid-induced osteoblast apoptosis that was peroxisome...
Non-small cell lung cancer (NSCLC) represents almost 85% of total diagnosed cancer. Studies have shown that combination DNA methyltransferase (DNMT) and histone deacetylase (HDAC) inhibitors is effective against various cancers, including However, optimizing the synergistic dose regime very difficult involves adverse side effects. Therefore, in this study, we cucurbitacin B (CuB), a single bioactive triterpenoid compound, inhibits both DNMTs HDACs starting at low 60 nmol/L NSCLC H1299 cells....
Spinacia oleracea is an important dietary vegetable in India and throughout the world has many beneficial effects. It cultivated globally. However, its effect on osteoarthritis that mainly targets cartilage cells remains unknown. In this study we aimed to evaluate anti-osteoarthritic chondro-protective effects of SOE chemically induced (OA).OA was by intra-patellar injection monosodium iodoacetate (MIA) at knee joint rats. then given orally 250 500 mg.kg- 1 day- doses for 28 days these...
Adiponectin is an adipocytokine that signals through plasma membrane-bound adiponectin receptors 1 and 2 (AdipoR1 -2). Plasma depletion associated with type diabetes, obesity, cardiovascular diseases. therapy, however, yet unavailable owing to its large size, complex multimerization, functional differences of the multimers. We report discovery characterization 6-C-β-D-glucopyranosyl-(2S,3S)-(+)-5,7,3',4'-tetrahydroxydihydroflavonol (GTDF) as orally active mimetic. GTDF interacted both...
Ulmus wallichiana Planchon (Family: Ulmaceae), a traditional medicinal plant, was used in fracture healing the folk tradition of Uttarakhand, Himalaya, India. The present study investigated cardioprotective effect ethanolic extract (EE) and butanolic fraction (BF) U. isoprenaline (ISO) induced cardiac hypertrophy Wistar rats. Cardiac by ISO (5 mg/kg/day, subcutaneously) Treatment performed oral administration EE BF (500 mg/kg/day 50 mg/kg/day). blood pressure (BP) heart rate (HR) were...
Abstract We recently reported that a butanol soluble fraction from the stem of Cassia occidentalis (CSE-Bu) consisting osteogenic compounds mitigated methylprednisone (MP)-induced osteopenia in rats, albeit failed to afford complete protection thus leaving substantial scope for further improvement. To this aim, we prepared an oral formulation was lipid-based self-nano emulsifying drug delivery system (CSE-BuF). The globule size CSE-BuF range 100–180 nm diluted emulsion and zeta potential −28...
Recently an increasing number of patients with complications related to pierced body jewellery have been seen. Often removal the is indicated. Removal these items may also be required for radiological purposes. If doctor familiar opening mechanism item, not usually difficult. Uninformed attempts at cause unnecessary trauma and distress. In a survey 28 accident emergency doctors, only six were able accurately describe mechanisms all three commonly used types jewellery. Descriptions currently...
Abstract Chemotherapy such as cisplatin is widely used to treat ovarian cancer either before or after surgical debulking. However, relapse due chemotherapy resistance a major challenge in the treatment of cancer. The underlying mechanisms related remain largely unclear. Therefore, identification effective therapeutic strategies urgently needed overcome therapy resistance. Transcriptome-based analysis, vitro studies and functional assays identified that cisplatin-resistant cells express high...
Abstract Cancer is a class of diseases that characterized by the uncontrollable or unstoppable growth abnormal cells with potential to invade spread other normal body parts. According WHO estimates, globally 10 million new cancer cases are diagnosed each year. Its 100% prevention becomes major challenge for scientific fraternity. Therefore, there an urgent need discover drugs could overcome present issue. In order meet challenges, library 22 novel 1H‐1,2,3‐triazol‐4‐yl‐methyl tethered...
Abstract Objective: The aim of this study was to demonstrate the efficacy extract derived from Spinacia oleracea (SOE) in reversing bone loss induced by ovariectomy and healing properties a drill-hole fracture model rats. Methods: SOE administered orally for 12 weeks adult ovariectomized Sprague Dawley rats after inducing osteopenic condition. Bone micro-architecture, expressions osteogenic resorptive gene markers, biomechanical strength, new formation, turnover markers were studied. Uterine...
The androgen receptor (AR) is activated in patients with castration resistant prostate cancer (CRPC) despite low circulating levels of androgen, suggesting that intracellular signaling pathways and non-androgenic factors may contribute to AR activation. Many G-protein coupled receptors (GPCR) their ligands are also these cells indicating they play a role development Prostate Cancer (PCa) CRPC. Although cross talk has been suggested between the two pathways, yet, identity GPCRs which...