A5002510023- Bone Metabolism and Diseases
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Bone health and treatments
- Bone health and osteoporosis research
- Retinoids in leukemia and cellular processes
- Drug Transport and Resistance Mechanisms
- Protein Degradation and Inhibitors
- Regulation of Appetite and Obesity
- Cancer therapeutics and mechanisms
- TGF-β signaling in diseases
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- Phytoestrogen effects and research
- Natural product bioactivities and synthesis
- Cholesterol and Lipid Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Multiple Myeloma Research and Treatments
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Chronic Lymphocytic Leukemia Research
Central Drug Research Institute
2015-2024
Council of Scientific and Industrial Research
2010-2024
Academy of Scientific and Innovative Research
2016-2024
Indian Institute of Toxicology Research
2011
Karolinska Institutet
2003-2007
Karolinska University Hospital
2007
Chonnam National University
2002-2004
The orphan nuclear receptor small heterodimer partner (SHP; NR0B2) interacts with a wide array of receptors and represses their transcriptional activity. SHP expression is regulated by several other members the superfamily, including SF-1 LRH-1, bile acid FXR. We have found that <i>SHP</i> promoter also activated estrogen receptor-related γ (ERRγ) but not related ERRα ERRβ isoforms. ERRγ mRNAs are coexpressed in tissues, pancreas, kidney, heart, confirming potential relevance this...
Abstract We recently reported that extracts made from the stem bark of Ulmus wallichiana promoted peak bone mass achievement in growing rats and preserved trabecular cortical strength ovariectomized (OVX) rats. Further, 6-C-β-D-glucopyranosyl-(2S,3S)-(+)-3',4',5,7-tetrahydroxyflavanol (GTDF), a novel flavonol-C-glucoside isolated extracts, had nonestrogenic bone-sparing effect on OVX Here we studied effects GTDF osteoblast function its mode action vivo osteogenic effect. stimulated...
Abstract Following a lead obtained from stem‐bark extract of Butea monosperma , two structurally related methoxyisoflavones; cajanin and isoformononetin were studied for their effects in osteoblasts. Cajanin had strong mitogenic as well differentiation‐promoting on osteoblasts that involved subsequent activation MEK‐Erk Akt pathways. On the other hand, exhibited potent anti‐apoptotic effect addition to promoting osteoblast differentiation parallel Unlike genistein or daidzein, none these...
Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management these cancers. Therefore chemo-sensitization cells could be promising strategy increasing efficacy conventional agents patients. Recent studies have indicated that chemo-preventive natural restore pro-apoptotic protein expression induce...
Type 2 diabetes is associated with increased fracture risk and delayed healing; the underlying mechanism, however, remains poorly understood. We systematically investigated skeletal pathology in leptin receptor-deficient diabetic mice on a C57BLKS background (db). Compared wild type (wt), db displayed reduced peak bone mass age-related trabecular cortical loss. Poor outcome contributed high-glucose- nonesterified fatty acid-induced osteoblast apoptosis that was peroxisome...
Coordinated regulation of bile acid biosynthesis, the predominant pathway for hepatic cholesterol catabolism, is mediated by few key nuclear receptors including orphan liver receptor homolog 1 (LRH-1), hepatocyte factor 4alpha (HNF4alpha), small heterodimer partner (SHP), and FXR (farnesoid X receptor). Activation initiates a feedback regulatory loop via induction SHP, which suppresses LRH-1- HNF4alpha-dependent expression 7alpha hydroxylase (CYP7A1) sterol 12alpha (CYP8B1), two major...
BACKGROUND AND PURPOSE Naringenin and its derivatives have been assessed in bone health for their oestrogen‐‘like’ effects but low bioavailability impedes clinical potential. This study was aimed at finding a potent form of naringenin with osteogenic action. EXPERIMENTAL APPROACH Osteoblast cultures were harvested from mouse calvaria to differentiation by naringenin, isosakuranetin, poncirin, phloretin naringenin‐6‐ C ‐glucoside (NCG). Balb/cByJ ovariectomized (OVx) mice without or...
The astrocyte marker, glial fibrillary acidic protein (GFAP), has essential functions in the brain, but may trigger astroglial scarring when expressed excess. Docosahexaenoic acid (DHA) is an n-3 fatty that protective during brain development. However, effect of DHA on GFAP levels developing remains unexplored. Here, we detected treating rats with DHA-enriched fish-oil caused dose-dependent augmentation. We investigated mechanism promoting GFAP, hypothesizing participation acid-binding...
Employing a rational design of thioaryl naphthylmethanone oxime ether analogs containing functional properties various anticancer drugs, series compounds were identified that displayed potent cytotoxicity toward cancer cells, out which 4-(methylthio)phenyl)(naphthalen-1-yl)methanone O-2-(diethylamino)ethyl (MND) exhibited the best safety profile. MND induced apoptosis, inhibited migration and invasion, strongly stem cell population on par with salinomycin, demonstrated orally tumor...
Adiponectin is an adipocytokine that signals through plasma membrane-bound adiponectin receptors 1 and 2 (AdipoR1 -2). Plasma depletion associated with type diabetes, obesity, cardiovascular diseases. therapy, however, yet unavailable owing to its large size, complex multimerization, functional differences of the multimers. We report discovery characterization 6-C-β-D-glucopyranosyl-(2S,3S)-(+)-5,7,3',4'-tetrahydroxydihydroflavonol (GTDF) as orally active mimetic. GTDF interacted both...
Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor that lacks a conventional DNA binding domain (DBD) and represses the transcriptional activity of various receptors. In this study, we examined novel cross talk between SHP BETA2/NeuroD, basic helix-loop-helix transcription factor. vitro in vivo protein interaction studies showed physically interacts with but not its E47. Moreover, confocal microscopic study immunostaining results demonstrated colocalized BETA2...