A5001096949- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Pregnancy-related medical research
- Pelvic floor disorders treatments
- Maternal and fetal healthcare
- Global Cancer Incidence and Screening
- Reconstructive Surgery and Microvascular Techniques
- Extracellular vesicles in disease
- Chemotherapy-induced cardiotoxicity and mitigation
- Gynecological conditions and treatments
- Gestational Trophoblastic Disease Studies
- Health Literacy and Information Accessibility
- Social Media in Health Education
- PI3K/AKT/mTOR signaling in cancer
- Healthcare Systems and Public Health
- Health and Medical Research Impacts
- Advances in Oncology and Radiotherapy
- Mental Health via Writing
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- BRCA gene mutations in cancer
- Endometriosis Research and Treatment
- Female Genital Mutilation/Cutting Issues
- Economic and Financial Impacts of Cancer
- Genomics and Rare Diseases
Medical College of Wisconsin
2021-2023
Loyola University Medical Center
2018-2022
Froedtert Hospital
2022
Loyola University Chicago
2018-2020
Florida State University
2014-2016
Abstract SPHK1 (sphingosine kinase‐1) catalyzes the phosphorylation of sphingosine to sphingosine‐1‐phosphate (S1P), is found be highly expressed in solid tumors. Here, extracellular vesicles (EVs) are identified as key transporters tumor microenvironment. Consequently, SPHK1‐packaged EVs elevate S1P levels microenvironment, where appears an immunosuppressive agent. However, exact mechanism how mediates its effects cancer not understood. It investigated that can induce T cell exhaustion....
The COVID-19 pandemic has quickly transformed healthcare systems with expansion of telemedicine. past year highlighted risks to immunosuppressed cancer patients and shown the need for health equity among vulnerable groups. In this study, we describe utilization virtual visits by gynecologic malignancies assess their social vulnerability.Virtual visit data 270 gynecology oncology at a single institution from March 1, 2020 August 31, was obtained querying cohort discovery tool. Through...
Ovarian cancer is the most lethal gynecological malignancy among women worldwide and characterized by aggressiveness, stemness, frequent relapse due to resistance platinum-based therapy. cells metastasize through ascites fluid as 3D spheroids which are more resistant apoptosis chemotherapeutic agents. However, precise mechanism an oncogenic addiction that makes agents not understood. To study signaling occurs during progression in patients, we developed endometrioid subtype ovarian cell line...
5510 Background: Patients with metastatic recurrent endometrial cancer have limited effective therapies. Single agent pembrolizumab is utilized in mismatch repair deficient (MMRd) patients, while the combination of lenvatinib and now more commonly used MMR intact patients who progressed after chemotherapy combinations. This trial investigated a novel three drug regimen. Methods: not amenable to curative intent surgery or radiation one two lines therapy were eligible regardless histology....
Background: Global outbreak detection and reporting have generally improved for a variety of infectious diseases geographic regions in recent decades. Nevertheless, lags remain threat to the global human health economy. In time between first occurrence novel disease incident public notification an outbreak, infected individuals greater possibility traveling spreading pathogen other nations. Shortening has potential improve by preventing local outbreaks from escalating into epidemics. Abstract
Therapeutic options for recurrent adult granulosa cell tumors (AGCT) are limited. After examining the hormonal pathways involved in
Regional recurrence of endometrial cancer is a challenging yet potentially curable group patients without defined standard care. Our aim to determine optimal methods salvage therapy for regionally recurrent cancer. Twenty-two cases nodal, pelvic, or peritoneal cavity recurrences were identified from single institution database. Univariable Cox proportional hazards models used estimate the risk second death. Kaplan-Meier plots probability progression free survival and overall among in three...
• Early use of extracorporeal membrane oxygenation (ECMO) is valuable when pulmonary tumor burden from GTN high. Induction chemotherapy cisplatin and etoposide was administered during ECMO successfully. The induction regimen led to exponential decline in beta-HCG after 1 cycle. Collaboration subspecialists necessary treat coexisting malignancy cardiopulmonary failure associated with GTN.
To investigate the role of an adherent soft silicone antimicrobial occlusive foam silver-impregnated dressing for reduction surgical site infections (SSI) in primary low-transverse caesarean section (1°LTCS) delivery.Women aged 18-45 years admitted to labour and delivery or antepartum unit undergoing a 1°LTCS were recruited. Exclusion criteria included repeat caesarean, vertical skin incision, intrapartum fever closure with staples. Consented participants delivered by scheduled unscheduled...
Abstract Racial and ethnic disparities in access to care treatment of cervical cancer exist. Despite being the standard care, brachytherapy as an essential component definitive irradiation is not successfully completed by all patients with locally advanced cancer. Milwaukee, WI, a city known for segregation there profound gap women continue be diagnosed cervix, disease that can detected early now even prevented HPV vaccine. Using geocoding, relationship between patients' geography,...
“What’s the terminal?” I asked question with ignorance of any student attempting to learn something new. However, unlike my previous queries that morning, this seemed elicit skepticism from staff and graduate students in Knight lab. It was first day Howard Hughes Medical Institute Summer Research Fellowship; while expected a challenge working human microbiome expert Dr. Rob Knight, never be as lost morning. This earned me an online tutorial on terminal command line, spent rest week...
Abstract Academic pipeline programs are designed to mitigate systemic barriers that have historically excluded individuals due deep-rooted, structural inequities. The Student-centered Pipeline Advance Research in Cancer Careers (SPARCC) was developed 2018 diversify the clinical research health professions workforce and has graduated three cohorts of scholars from 2019-2021. Due COVID-19 safety concerns, SPARCC evolved, pivoting establish effective learning environments virtually in-person...
11018 Background: Imposter syndrome (IS) is defined as an inability to believe that one’s success deserved. It commonly encountered by physicians, with cited statistics ranging from 22% 98%, associated negative mental health impacts and can be harmful wellbeing. Given increasing SM use in hematology/oncology (H/O), we aimed evaluate the effect of on IS among oncology trainees oncologists. Methods: An anonymous online survey was distributed oncologists through platforms (Twitter, Facebook...