A5101854416- Bone Metabolism and Diseases
- Pharmacological Effects of Medicinal Plants
- Bone health and osteoporosis research
- Osteoarthritis Treatment and Mechanisms
- RNA Research and Splicing
- MicroRNA in disease regulation
- Hormonal and reproductive studies
- GDF15 and Related Biomarkers
- Bone health and treatments
- Molecular Biology Techniques and Applications
- Protein Hydrolysis and Bioactive Peptides
- Hip and Femur Fractures
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Genetic and phenotypic traits in livestock
- Inflammatory mediators and NSAID effects
- Biological Stains and Phytochemicals
- Phytochemicals and Medicinal Plants
- Medicinal Plants and Neuroprotection
- Natural product bioactivities and synthesis
- Ocular Diseases and Behçet’s Syndrome
- Morinda citrifolia extract uses
- Reproductive Physiology in Livestock
- Bioactive Compounds and Antitumor Agents
- Caveolin-1 and cellular processes
The University of Agriculture, Peshawar
2023-2024
Icahn School of Medicine at Mount Sinai
2019-2022
Mafraq Hospital
2022
Manchester University NHS Foundation Trust
2022
University of Veterinary and Animal Sciences
2021
Central Drug Research Institute
2014-2020
John Wiley & Sons (United States)
2020
Council of Scientific and Industrial Research
2014-2019
International Islamic University, Islamabad
2019
International University
2019
The primitive neurohypophyseal nonapeptide oxytocin (OXT) has established functions in parturition, lactation, appetite, and social behavior. We have shown that OXT direct actions on the mammalian skeleton, stimulating bone formation by osteoblasts modulating genesis function of bone-resorbing osteoclasts. deleted receptors (OXTRs) selectively osteoclasts using Col2.3Cre Acp5Cre mice, respectively. Both male female Col2.3Cre+:Oxtrfl/fl mice recapitulate low-bone mass phenotype Oxtr+/-...
This research proposes a mobile and cloud-based framework for the automatic detection of diabetic foot ulcers conducts an investigation its performance. The system uses cross-platform which enables deployment apps to multiple platforms using single TypeScript code base. A deep convolutional neural network was deployed platform where app could send photographs patient's feet inference detect presence ulcers. functionality usability were tested in two clinical settings: Salford Royal NHS...
The search for suitable manufacturing methods and the selection of biocompatible material with good mechanical properties is still a major challenge in implant development. polyethylene terephthalate glycol (PETG) thermoplastic extensively utilized biomedical applications, like tissue engineering, dental, scaffolds surgery, because its biocompatibility. Fused deposition modeling (FDM) gaining importance wide range applications developing custom shaped medical implants. This study aimed to...
A formulation of quercetin-based solid lipid nanoparticles (QSLNs) was developed to increase the bioavailability quercetin, with an aim evaluate its effects on bone health in comparison free quercetin (Q).
Spinacia oleracea is an important dietary vegetable in India and throughout the world has many beneficial effects. It cultivated globally. However, its effect on osteoarthritis that mainly targets cartilage cells remains unknown. In this study we aimed to evaluate anti-osteoarthritic chondro-protective effects of SOE chemically induced (OA).OA was by intra-patellar injection monosodium iodoacetate (MIA) at knee joint rats. then given orally 250 500 mg.kg- 1 day- doses for 28 days these...
Abstract The combination of metabolic modulators with chemotherapy holds vast promise for effective inhibition tumor progression and invasion. Herein, a ratiometric codelivery platform is developed metformin (MET), known modulator topotecan (TPT), chemotherapeutic drug, by engineering lipid bilayer–camouflaged mesoporous silica nanoparticles (LB‐MSNs). In an attempt to deliver maintain high site concentrations MET TPT, novel ion pairing–assisted loading procedure using pamoic acid (PA) as in...
Post-menopausal condition augments the biological aging process, characterized by multiple metabolic disorders in which bone loss is most prevalent outcome and usually coupled with sarcopenia. Coexistence of such associated pathogenesis have much worse health outcomes, compared to individuals osteoporosis only. Pre- post-natal development demands calcium from mother fetus during pregnancy lactation leading a significant maternal skeletal loss. It follows an anabolic phase around weaning...
Abstract Externally visible body and longitudinal bone growth is a result of proliferation chondrocytes. In disorder, there delay in the age associated increase height. The present study evaluates effect extract from transgenic tomato fruit expressing AtMYB12 transcription factor on health including growth. Constitutive expression led to significantly enhanced biosynthesis flavonoids general flavonol particular. Pre-pubertal ovary intact BALB/c mice received daily oral administration vehicle...
Significance Tadalafil and vardenafil are among the most widely used drugs for erectile dysfunction, which affects nearly 19% of men over 20 y age. Older also suffer from age-related bone loss resulting in crippling fractures. We show that mice, both agents act on cells, formation new reduced removal old bone. Because this net gain mass, we posit tadalafil could be cotreating dysfunction osteoporosis advancing age, as well treating postmenopausal women. recommend future clinical studies to...
MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays critical role regulating osteoblast differentiation and bone mass. Global deletion ( Maf1 -/- mice) produced high mass phenotype. However, osteoblasts isolated from mice showed reduced osteoblastogenesis ex vivo. Therefore, determined the phenotype overexpressing cells mesenchymal lineage Prx1 -Cre;LSL- mice). These increased Ex vivo,...
Abstract Objectives This study was undertaken to investigate the effects of a heartwood ethanolic extract (HEE) made from Dalbergia sissoo on facture healing and in prevention pathological bone loss resulting estrogen deficiency ovariectomized (Ovx) rats. Methods Heartwood (250, 500 1000 mg/kg per day) administered orally immediately next day after drill-hole injury continued for 2 weeks. Ovx rats received HEE at same doses 12 weeks compared with 17-β estradiol (E2; 100 μg/kg 5 days/week...
Abstract Objective: The aim of this study was to demonstrate the efficacy extract derived from Spinacia oleracea (SOE) in reversing bone loss induced by ovariectomy and healing properties a drill-hole fracture model rats. Methods: SOE administered orally for 12 weeks adult ovariectomized Sprague Dawley rats after inducing osteopenic condition. Bone micro-architecture, expressions osteogenic resorptive gene markers, biomechanical strength, new formation, turnover markers were studied. Uterine...
The objectives were to investigate the ovarian dynamics and hormonal profiles during oestrus cycle, characterize uterine blood flow (OBF versus UBF) indices on extent of vascular perfusion towards dominant follicle (DF) or corpus luteum (CL) peri-ovulatory follicular wave in Sahiwal cows. In experiment 1, cyclic cows (n = 21) selected at their spontaneous (day 0) subjected B-mode ultrasonography throughout cycle. 2, 9) randomly day 0, categorized according intra-ovarian patterns as ovaries...