A5101613010- Bone Metabolism and Diseases
- Bone health and treatments
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Thyroid Disorders and Treatments
- Mitochondrial Function and Pathology
- Vitamin D Research Studies
- Global Cancer Incidence and Screening
- Digital Media and Visual Art
- Neonatal and fetal brain pathology
- interferon and immune responses
- Cervical Cancer and HPV Research
- Probiotics and Fermented Foods
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Conflict of Laws and Jurisdiction
- Cell Adhesion Molecules Research
- BRCA gene mutations in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Health and Technologies
- Bone health and osteoporosis research
- Sexual function and dysfunction studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Lysosomal Storage Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
Nanjing University of Chinese Medicine
2025
Jiangsu Province Hospital
2025
Tianjin Medical University
2025
Institute of Physiology and Basic Medicine
2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2022-2025
University of Electronic Science and Technology of China
2024
Chengdu Medical College
2024
Sichuan Cancer Hospital
2024
Fujian Normal University
2023
Nantong University
2015-2022
In nonneuronopathic type 1 Gaucher disease (GD1), mutations in the glucocerebrosidase gene (GBA1) result deficiency and accumulation of its substrate, glucocerebroside (GL-1), lysosomes mononuclear phagocytes. This prevailing macrophage-centric view, however, does not explain emerging aspects disease, including malignancy, autoimmune Parkinson osteoporosis. We conditionally deleted GBA1 hematopoietic mesenchymal cell lineages using an Mx1 promoter. Although this mouse fully recapitulated...
We recently described the direct effects of thyroid-stimulating hormone (TSH) on bone and suggested that loss in hyperthyroidism, hitherto attributed solely to elevated thyroid levels, could at least part arise from accompanying decrements serum TSH. Recent studies both mice human subjects provide compelling evidence hormones TSH have opposite skeleton. Here, we show TSH, when injected intermittently into rodents, even intervals 2 weeks, displays a powerful antiresorptive action vivo . By...
The treatment of stroke is limited by a short therapeutic window and lack effective clinical drugs. Methylene blue (MB) has been used in laboratories clinics since the 1890s. Few studies have reported neuroprotective role MB cerebral ischemia-reperfusion injury. However, whether how protects against acute ischemia (ACI) injury was unclear. In this study, we investigated effect on revealed that protected ACI augmenting mitophagy. Using rat middle artery occlusion (MCAO) model, demonstrated...
Diabetic Cardiomyopathy (DCM) is a heart condition that arises specifically from diabetes mellitus, characterized by cardiac dysfunction in the absence of coronary artery disease or hypertension. The prevalence DCM rising tandem with global increase diabetes, necessitating development early diagnostic markers and therapeutic targets. This study integrates bioinformatics analysis experimental validation to identify potential biomarkers for DCM. We performed gene expression data mining Gene...
Background Given the absence of specific pharmacological treatments for sarcopenia, identifying effective lifestyle and dietary interventions is imperative. This study aims to explore association between composite antioxidant index (CDAI) offering new insights into nutritional strategies sarcopenia-prone populations. Methods cross-sectional analysed secondary data from National Health Nutrition Examination Survey cycles spanning 2001–2006 2011–2018. Weighted multivariate logistic regression...
Exposure to hypobaric hypoxia during rapid ascent high altitudes significantly impacts intestinal barrier function. Goblet cells, as one of the primary cell types in mucosa, play a crucial role maintaining this barrier. However, effects on goblet function and underlying molecular mechanisms remain unclear. In study, we established mouse model exposure (simulating an altitude 6,000 meters) studied its colonic cells by transcriptomic analysis. Additionally, hypoxia-treated (1% O 2 ) line...
Clinical data showing correlations between low thyroid-stimulating hormone (TSH) levels and high bone turnover markers, mineral density, an increased risk of osteoporosis-related fractures are buttressed by mouse genetic pharmacological studies identifying a direct action TSH on the skeleton. Here we show that skeletal actions deficiency mediated, in part, through TNFα. Compound mutants generated genetically deleting Tnf α gene Tshr −/− (homozygote) or +/− (heterozygote) background resulted...
Significance Tadalafil and vardenafil are among the most widely used drugs for erectile dysfunction, which affects nearly 19% of men over 20 y age. Older also suffer from age-related bone loss resulting in crippling fractures. We show that mice, both agents act on cells, formation new reduced removal old bone. Because this net gain mass, we posit tadalafil could be cotreating dysfunction osteoporosis advancing age, as well treating postmenopausal women. recommend future clinical studies to...
Abstract Hypoxia as a microenvironment or niche stimulates proliferation of neural stem cells (NSCs). However, the underlying mechanisms remain elusive. Autophagy is protective mechanism by which recycled cellular components and energy are rapidly supplied to cell under stress. Whether autophagy mediates NSCs hypoxia how induces unclear. Here, we report that facilitates embryonic NSC through HIF-1/mTORC1 signaling pathway-mediated autophagy. Initially, found greatly induced in NSCs, while...
(Abstracted from Nature 2017;546:107–112) Osteoporosis is common in postmenopausal women because of cessation menstruation. Bone loss occurs most rapidly during late perimenopause—a period characterized by relatively stable estrogen and rising follicle-stimulating hormone (FSH) levels as a result ovarian failure.
Background: This study aimed to explore the current knowledge level of breast cancer among rural women in Southwest China and analyze influencing factors cognition.Methods: From May November 2022, 1468 were invited participate this study.Demographic information Chinese version Breast Cancer Awareness Measure (C-BCAM) collected through one-on-one investigations.The data analyzed using descriptive statistics, chi-square tests, multiple regression analysis SPSS 26.0. Results:The included a...
Steroid receptor coactivator (SRC)-1 mediates nuclear hormone receptors and transcription factor-dependent (1), interacts with STAT3 (2) an important mediator of leptin-induced POMC expression hence satiety (3). Src-1 knockout mice are obese (4), however, the underlying mechanism is unclear. In a compelling line evidence, these authors suggest that SRC-1 deficiency might impair leptin action via reduced activation. They show deficient have lower leptin-stimulated pSTAT3 binding to Pomc...
The determination of parentage foreign surrogacy directly involves the protection rights and interests surrogate child, commissioning parents mother, is also a prerequisite for guardianship custody child. At present, China faced with dilemma that criteria determining "foreign surrogacy" are not in line international trends, current Law on Application Laws lacks clear appropriate conflict rules parent-child relationship". Therefore, it necessary to reconstruct law applicable relationships...