A5060108385- Aquaculture disease management and microbiota
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Aquaculture Nutrition and Growth
- Immune Response and Inflammation
- Infant Nutrition and Health
- Neuropeptides and Animal Physiology
- Bat Biology and Ecology Studies
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Acute Lymphoblastic Leukemia research
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Virus-based gene therapy research
- Microbial infections and disease research
- Protein Hydrolysis and Bioactive Peptides
- Neuroendocrine regulation and behavior
- Physiological and biochemical adaptations
- Cancer-related molecular mechanisms research
- Antimicrobial Peptides and Activities
- Genetics and Neurodevelopmental Disorders
- Biochemical and Structural Characterization
- Reproductive Physiology in Livestock
Shandong Academy of Sciences
2025
Qilu University of Technology
2025
Beijing Forestry University
2014-2024
China West Normal University
2024
Hunan University
2024
Yale University
2016-2024
Xian Central Hospital
2012-2023
Shanghai Traditional Chinese Medicine Hospital
2023
Northwest University
2023
Shanghai Sixth People's Hospital
2023
Walnut is unique because they have a perfect balance of n-6 and n-3 polyunsaturated fatty acids. The increasing market demand walnut lipids results in the large amount oil extraction residue. residue rich nutritional proteins, uneconomic use by-product discouraged development industry. Anticancer peptides recently received attention as alternative chemotherapeutic agents that overcome limits current drugs. aim this study was to investigate whether anticancer bioactive peptide contained...
Abstract Recombinant adeno-associated viruses (rAAVs) are currently considered the safest and most reliable gene delivery vehicles for human therapy. Three serotype capsids, AAV1, AAV2, AAV9, have been approved commercial use in patients, but they may not be suitable all therapeutic contexts. Here, we describe a novel capsid identified clinical sample by high-throughput, long-read sequencing. The capsid, which named AAVv66, shares high sequence similarity with AAV2. We demonstrate that...
Defects and heteroatom doping are two refined microstructural factors that significantly affect the performance of photocatalytic materials. Coupling defect engineering is a powerful approach for designing efficient photocatalysts. In this research, we successfully construct dual defect-engineered BiVO4 nanosheets (BVO-N-OV) by introducing N oxygen vacancies through ammonium oxalate-assisted thermal treatment nanosheets. Due to combined enhancement band structure surface properties from...
A cDNA encoding hepcidin was isolated from a library of spleen red sea bream (Chrysophrys major) by expressed sequence tag analysis. The expression the mRNA in various tissues examined. Challenge with Escherichia coli DH5alpha elevated levels spleen, gill, liver, and intestine.
Oviductus Ranae is the dry oviduct of Rana chensinensis, which also called R. chensinensis oil. a valuable Chinese crude drug and recorded in Pharmacopoeia People's Republic China. The aim this study was to investigate immunostimulatory activity protein hydrolysate (ORPH) assess its possible mechanism. Immunomodulatory ORPH examined murine macrophage RAW 264.7 cells. effect on phagocytic macrophages determined by neutral red uptake assay. After treatment with ORPH, NO production levels...
The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein Phosphatase) is an important regulator of synaptic function. normally opposes strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR) internalization through dephosphorylation GluN2B and inactivation the kinases extracellular signal–regulated kinase 1/2 Fyn. Here we show that STEP61 elevated in cortex Nrg1+/− knockout mouse model schizophrenia (SZ). Genetic reduction or pharmacological inhibition...
Chronic obstructive pulmonary disease (COPD) has higher mortality when developing to acute exacerbation (AECOPD); hence, the early intervention of COPD is critical for preventing AECOPD. Exploring serum metabolites associated with in patients will contribute COPD.In study, a non-targeted metabolomics strategy combined multivariate statistical methods was performed explore metabolic profiling exacerbation, screen potential AECOPD and analyze value these predicting development COPD.Serum...
The purpose of this study was to investigate seasonal changes spermatogenesis and the cellular localization P450c17 P450arom in wild male ground squirrels during breeding non-breeding seasons. testicular weight, size score count from April September were measured, histological immunohistochemical observations tissues performed squirrels. In addition, total proteins extracted tissue seasons used for Western blotting analysis P450arom. There marked variations season (April) (September)....
Abstract Background The interface zone, area around invasive carcinoma, can be thought of as the actual tissue tumor microenvironment with precedent alterations for invasion. However, heterogeneity and characteristics in have not yet been thoroughly explored. Methods For vitro studies, single-cell RNA sequencing (scRNA-seq) was used to characterize cells from normal zone 5-mm-wide belts between invasion front zone. Through scRNA-seq data analysis, we compared cell types their transcriptional...
Abstract Microsatellite markers have been developed from a complementary DNA (cDNA) library of red sea bream, Chrysophrys major . Twenty‐eight microsatellites were selected for designing microsatellite primers, which 11 gave working primer pairs. Observed and expected heterozygosities varied 0.33 to 1.00 0.38 0.83, respectively. Five additional fish species assessed cross‐species amplification revealed between one six positive amplifications 0 6 polymorphic loci per species.
Background/Aims: Obesity and the related metabolic syndrome have emerged as major public health issues in modern society. miRNAs been shown to play key roles regulating obesity-related syndrome, some regulated by adiponectin were identified novel targets for controlling adipose tissue inflammation. miR-378 is a candidate target that was be involved differentiation, mitochondrial metabolism systemic energy homeostasis. However, little known about regulatory mechanisms of expression. To better...
Malathion (MT) and chlorpyrifos (CPF) are immunotoxic organophosphate pesticides that used extensively in agriculture worldwide. Dietary polyphenols protect against a variety of toxins. In this study, walnut polyphenol extract (WPE) prevents MT- or CPF-induced toxicity to splenic lymphocytes vitro. WPE promotes the proliferation MT-exposed splenocytes, as indicated by increases proportions T-lymphocyte subpopulations (CD3+, CD4+, CD8+ T cells) levels T-cell-related cytokines interleukin...
Five cell lines (LJHK, LJS, LJL, LJH‐1 and LJH‐2) were established from the head kidney, spleen, liver heart of sea perch Lateolabrax japonicus . The LJHK, LJH‐2 subcultured 46, 32, 36 34 times in minimum essential medium (MEM) supplemented with foetal bovine serum (FBS), 10 ng ml −1 basic fibroblast growth factor (bFGF). Morphology primary cultures subcultures five observed continuously by microscopy. suitable temperature for was 18 to 30° C all these optimum at 24° a reduced rate <18°...
Abstract Christianson syndrome (CS) is an X-linked disorder resulting from loss-of-function mutations in SLC9A6 , which encodes the endosomal Na + /H exchanger 6 (NHE6). Symptoms include early developmental delay, seizures, intellectual disability, nonverbal status, autistic features, postnatal microcephaly, and progressive ataxia. Neuronal development impaired CS, involving defects neuronal arborization synaptogenesis, likely underlying diminished brain growth postnatally. In addition to...
Mycoplasma synoviae can cause worldwide respiratory diseases, synovitis, or subclinical symptoms in poultry. M. infection occurs throughout the yr and causes significant economic losses, including increased mortality, condemnations, medication, live production cost. In present study, seroprevalence of among 44,395 non-vaccinated chickens from 21 provinces China 2010 to 2015 was estimated using ELISA. The overall 41.19%. Seropositive rates different ranged between 24.70 57.20%; highest...