A5057189871- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Zeolite Catalysis and Synthesis
- Crystal structures of chemical compounds
- Advanced NMR Techniques and Applications
- Chemical Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Mesoporous Materials and Catalysis
- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Natural Compounds
- Luminescence Properties of Advanced Materials
- Luminescence and Fluorescent Materials
- Phenothiazines and Benzothiazines Synthesis and Activities
- Lanthanide and Transition Metal Complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Catalytic Processes in Materials Science
- Advanced Photocatalysis Techniques
- Polyoxometalates: Synthesis and Applications
- Analytical chemistry methods development
- Covalent Organic Framework Applications
- Advanced biosensing and bioanalysis techniques
- Advanced MRI Techniques and Applications
Chinese Academy of Sciences
2016-2025
Suzhou Institute of Nano-tech and Nano-bionics
2016-2025
Wuhan University of Science and Technology
2024-2025
Beijing Proteome Research Center
2024
Lifetech Scientific (China)
2023-2024
University of Science and Technology of China
2020-2024
Hebei University
2024
Heilongjiang University of Science and Technology
2013-2023
China Academy of Engineering Physics
2019-2023
Wuhan Institute of Technology
2022-2023
The Brønsted/Lewis acid synergy in dealuminated HY zeolite has been studied using solid-state NMR and density function theory (DFT) calculation. 1H double quantum magic-angle spinning (DQ-MAS) results have revealed, for the first time, detailed spatial proximities of Lewis Brønsted sites. from 13C adsorbed acetone as well DFT calculation demonstrated that considerably enhanced strength zeolite. Two types sites (with acidity) close proximity to extra-framework aluminum (EFAL) species were...
Developing new materials for the fabrication of proton exchange membranes (PEMs) fuel cells is great significance. Herein, a series highly crystalline, porous, and stable covalent organic frameworks (COFs) have been developed by stepwise synthesis strategy. The synthesized COFs exhibit high hydrophilicity excellent stability in strong acid or base (e.g., 12 m NaOH HCl) boiling water. These features make them ideal platforms conduction applications. Upon loading with H3 PO4 , (H3 @COFs)...
The 31P NMR chemical shifts of adsorbed trimethylphosphine oxide (TMPO) and the configurations corresponding TMPOH+ complexes on Brønsted acid sites with varying strengths in modeled zeolites have been predicted theoretically by means density functional theory (DFT) quantum calculations. configuration each complex was optimized at PW91/DNP level based an 8T cluster model, whereas were calculated gauge including atomic orbital (GIAO) approach both HF/TZVP MP2/TZVP levels. A linear correlation...
An γFe2 O3 @Au core/shell-type magnetic gold nanoflower-based theranostic nano-platform is developed. It integrated with ultrasensitive surface-enhanced Raman scattering imaging, high-resolution photo-acoustics real-time resonance and photothermal therapy capabilities.
Reversible luminescence modulation of upconversion phosphors has the potential applications as photoswitches and optical memory data storage devices. Previously, photochromic reaction was extensively used for realization reversible modulation. It is very necessary to develop other approaches such thermomchromic obtain In this work, WO3:Yb3+,Er3+ with various colors were prepared at temperatures, exhibiting tunable attributed formation oxygen vacancies in host. Upon heat treatment reducing...
A comprehensive study has been made to probe the spatial proximities among different acid sites in dealuminated H-Y zeolites modified with various degrees of calcination, steam, and treatments by using a variety solid-state NMR techniques, including multinuclear MAS two-dimensional 1H double-quantum (DQ) spectroscopy. The effects dealumination on nature, concentration, location extraframework Al species were followed DQ hydroxyl protons conjunction 1H, 27Al, 29Si results. It was found that...
The validity of using 31P NMR adsorbed trimethylphosphine (TMP) as a probe molecule for discerning the types (Brønsted vs Lewis) and strengths acid sites in solid catalysts have been studied by density functional theory (DFT) calculations. Brønsted with varied acidic covering from weak, strong, to superacid, mimicked 8T zeolite cluster models having different Si−H bond lengths hence proton affinities, were examined together Lewis systems metallic centers, e.g., BClnF3−n (n = 0−3), AlClnF3−n...
A comprehensive study has been made to predict the adsorption structures and 31P NMR chemical shifts of various trialkylphosphine oxides (R3PO) probe molecules, viz., trimethylphosphine oxide (TMPO), triethylphosphine (TEPO), tributylphosphine (TBPO), trioctylphosphine (TOPO), by density functional theory (DFT) calculations based on 8T zeolite cluster models with varied Si−H bond lengths. linear correlation between proton affinity (PA) was observed for each homologous R3PO molecules...
Magnetic resonance imaging (MRI) is a powerful and widely used clinical technique in cancer diagnosis. MRI contrast agents (CAs) are often to improve the quality of MRI-based In this work, we developed positive T1 CA based on graphene oxide (GO)–gadolinium (Gd) complexes. our strategy, diethylenetriaminepentaacetic acid (DTPA) chemically conjugated GO, followed by Gd(III) complexation, form (GO–DTPA–Gd). We have demonstrated that GO–DTPA–Gd system significantly improves relaxivity leads...
Deuterated pyridine (pyridine-d5) is one of the NMR probe molecules widely used for determination acid strength solid catalysts. However, correlation between 1H chemical shift adsorbed pyridine-d5 and Brønsted acids has rarely been investigated. Here, an 8T zeolite model with different Si−H bond lengths to represent sites strengths (from weak, strong, superacid) predict adsorption structure as well shift. The theoretical calculation suggests that a smaller pyridinium ions on indicates...
In order to improve the solubility of diflunisal (DIF), and hence oral bioavailability, two 2:1 cocrystals were prepared by solution crystallization from ethanol with nicotinamide (NIC) or isonicotinamide (ISO) as coformer. The characterized powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), well liquid- solid-state nuclear magnetic resonance (LNMR SSNMR). PXRD NMR measurements indicate that pure can be obtained even DIF...
The crystal structure of the theophylline–nicotinamide cocrystal is determined for first time by using a combined multi-technique approach.
A novel aptamer modified thermosensitive liposome was designed as an efficient magnetic resonance imaging probe. In this paper, Gd-DTPA encapsulated into optimized (TSL) formulation, followed by conjugation with AS1411 for specific targeting against tumor cells that overexpress nucleolin receptors. The resulting liposomes were extensively characterized in vitro a contrast agent. As-prepared TSLs-AS1411 had diameter about 136.1 nm. No obvious cytotoxicity observed from MTT assay, which...
Abstract Developing new materials for the fabrication of proton exchange membranes (PEMs) fuel cells is great significance. Herein, a series highly crystalline, porous, and stable covalent organic frameworks (COFs) have been developed by stepwise synthesis strategy. The synthesized COFs exhibit high hydrophilicity excellent stability in strong acid or base (e.g., 12 m NaOH HCl) boiling water. These features make them ideal platforms conduction applications. Upon loading with H 3 PO 4 , (H...
The strength and distribution of Brønsted acidic protons in anhydrous phosphomolybdic acid (H3PMo12O40, HPMo) have been studied by solid-state magic-angle-spinning (MAS) NMR, using trimethylphosphine oxide (TMPO) as the probe molecule conjunction with density functional theory (DFT) calculations. sties strengths exceeding threshold superacidity (Zheng, A. et al. J. Phys. Chem. B 2008, 112, 4496) were observed for HPMo. In addition, locations adsorption structures on various oxygen sites HPMo...
A novel pharmaceutical cocrystal (THPAH12) of Theophylline (THP) was obtained with an artificial sweetener, Acesulfame (AH), in a molar ratio 1:2. Solid state NMR spectra the indicate that two AH molecules exist as keto and enol tautomers, which is further confirmed by refined crystal structure. THPAH12 first form containing cocrystal. This highlights fact not only −OH AH, but also −NH–C═O group should be considered when designing new cocrystals via supramolecular synthon approach. Compared...
Four pharmaceutical cocrystals of naringenin were obtained, which demonstrate improved dissolution performance.
Flavonoids are a class of important natural chemicals that can be isolated from wide range plants. exhibit diverse pharmacological activities, although most them slightly soluble or insoluble in water, resulting low bioavailability after oral administration. To improve the dissolution performance these compounds, we selected sweetener, betaine (BTN), to form cocrystals with flavonoids. In this study, cocrystallization trials between BTN and three flavonoid baicalein (BAI), phloretin (PHL),...