A5100363038- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Pharmacological Effects of Natural Compounds
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Protease and Inhibitor Mechanisms
- Diabetes Treatment and Management
- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Crystal structures of chemical compounds
- Fungal Biology and Applications
- Drug Solubulity and Delivery Systems
- Crystallography and molecular interactions
- Drug Transport and Resistance Mechanisms
- Magnetism in coordination complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Marine Sponges and Natural Products
- Drug-Induced Hepatotoxicity and Protection
- Chromatography in Natural Products
- Fluorine in Organic Chemistry
- Berberine and alkaloids research
- DNA and Nucleic Acid Chemistry
- Phytochemistry and Biological Activities
- Analytical Chemistry and Chromatography
Central South University
2019-2025
Xiangya Hospital Central South University
2022-2025
University of Science and Technology Beijing
2021-2024
North Sichuan Medical University
2024
Affiliated Hospital of Nantong University
2023
Shenyang Pharmaceutical University
2005-2023
Icahn School of Medicine at Mount Sinai
2023
Institute of Hematology & Blood Diseases Hospital
2022-2023
Nantong University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Abstract Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have similar DNA-binding properties, only is active against colorectal tumors. The mechanisms for this tumor specificity of compounds are poorly understood but could be related to differences in uptake. This study shows that human organic cation transporters (OCT) 1 2 (SLC22A1 SLC22A2) markedly increase oxaliplatin, not cisplatin or accumulation cytotoxicity transfected cells, indicating an...
Fabrication of biomimetic photocatalytic systems consisting PI-COFs and molecular Ni complexes for selective reduction CO<sub>2</sub>is demonstrated.
Abstract Chronic diabetic wounds are a serious complication of diabetes and often result in limb amputations confer high mortality rates. The proinflammatory secretome the wound perpetuates defective neovascularization contributes to dysregulated tissue repair. This study aims design gelatin methacrylamide (GelMA) hydrogel sustained release grancalcin‐neutralizing antibody (GCA‐NAb) evaluate it as potential scaffold promote healing. Results show that expression grancalcin(GCA), protein...
Abstract Sleep deficiency is associated with obesity, but the mechanisms underlying this connection remain unclear. Here, we identify a sleep-inducible hypothalamic protein hormone in humans and mice that suppresses obesity. This cleaved from reticulocalbin-2 (RCN2), name it Raptin. Raptin release timed by circuit vasopressin-expressing neurons suprachiasmatic nucleus to RCN2-positive paraventricular nucleus. levels peak during sleep, which blunted sleep deficiency. binds glutamate...
3C-like (3CL) protease is essential for the life cycle of severe acute respiratory syndrome-coronavirus (SARS-CoV) and therefore represents a key anti-viral target. A compound library consisting 960 commercially available drugs biologically active substances was screened inhibition SARS-CoV 3CL protease. Potent achieved using mercury-containing compounds thimerosal phenylmercuric acetate, as well hexachlorophene. As well, 1-10 microM each inhibited viral replication in Vero E6 cell culture....
This work represents the first directed study to identify modification points in topology of a representative DPP8/9-inhibitor, capable rendering selectivity for DPP8 over DPP9. The availability DPP8-selective compound would be highly instrumental studying and untwining biological roles DPP9 disambiguation effects nonselective DPP-inhibitors that have mainly been ascribed blocking DPPIV's action. cell-permeable DPP8/9-inhibitor 7 was selected as lead dissected into several substructures were...
Core-shell microspheres have attracted widespread attention in the field of drug delivery due to their special morphology and excellent surface properties. However, preparation core–shell composed hydroxyapatite (HA) been rarely reported. In this paper, porous HA were prepared through a one-step hydrothermal method by using sodium trimetaphosphate (STMP) as phosphorus source. SEM TEM observations showed that shell solid core, with gap between core shell. These bear uniform size identical...
A diverse array of bioactive compounds have been isolated and characterized from the mangrove plant Avicennia marina its endophytes.Extensive chemical investigations different parts (barks, leaves, twigs, etc.) A. endophytes (mainly endophytic fungi) resulted in reporting isolation 123 compounds, most them are new or novel compounds.Most produced by were components host marina, but it can still be found that some metabolites possess same structure unit.It suggested there exist biogenetic...
Four pharmaceutical cocrystals of naringenin were obtained, which demonstrate improved dissolution performance.
Metals play essential roles in life by coordination with small molecules, proteins, and nucleic acids. Although the of copper ions many proteins methanobactins is known, chemistry Cu(II) natural products their biological functions remain underexplored. Herein, we report discovery a Cu(II)-binding product, chalkophomycin (CHM, 1), from Streptomyces sp. CB00271, featuring an asymmetric square-coordination system bidentate diazeniumdiolate conjugated 1H-pyrrole 1-oxide-oxazoline. The structure...
Matrine (MAR), oxymatrine (OMAR), and sophoridine (SPD) are natural alkaloids with varying biological activities; matrine was recently used for the treatment of coronavirus disease 2019 (COVID-19). However, short half-lives rapid elimination these matrine-type would lead to low oral bioavailability serious side effects. Herein, resveratrol (RES) selected as a co-former prepare their co-amorphous systems improve therapeutic index. The formation MAR-RES, OMAR-RES, SPD-RES established through...