A5040528958- Ubiquitin and proteasome pathways
- Antibiotic Resistance in Bacteria
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- Metal complexes synthesis and properties
- Curcumin's Biomedical Applications
- Alkaloids: synthesis and pharmacology
- Multiple Myeloma Research and Treatments
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Metal-Catalyzed Oxygenation Mechanisms
- Inflammasome and immune disorders
- Berberine and alkaloids research
- Graphene and Nanomaterials Applications
- Antimicrobial agents and applications
- Dendrimers and Hyperbranched Polymers
- Lung Cancer Treatments and Mutations
- Polysaccharides Composition and Applications
- Endoplasmic Reticulum Stress and Disease
- Proteoglycans and glycosaminoglycans research
- HER2/EGFR in Cancer Research
- Polysaccharides and Plant Cell Walls
- Pharmacological Effects of Natural Compounds
- Nuclear Structure and Function
- Catalytic C–H Functionalization Methods
Central South University
2020-2024
Nanjing Normal University
2018-2023
Nanjing Library
2019
Nanjing Forestry University
2017
To increase the efficacy of small molecule chemotherapeutic drug (SMCD) and reduce its toxic side effects, we selected two model drugs doxorubicin (DOX) chloroquine (CQ). DOX is a SMCD CQis chemosensitizer with autophagy inhibition. Poly(lactic-co-glycolic acid) (PLGA) alpha-tocopherol polyethylene glycol 1000 succinate were chosen as delivery carriers to design prepare novel type co-delivery single-nanoparticles by emulsification-solvent volatilisation, named NPDOX+CQ. The physicochemical...
Metals play essential roles in life by coordination with small molecules, proteins, and nucleic acids. Although the of copper ions many proteins methanobactins is known, chemistry Cu(II) natural products their biological functions remain underexplored. Herein, we report discovery a Cu(II)-binding product, chalkophomycin (CHM, 1), from Streptomyces sp. CB00271, featuring an asymmetric square-coordination system bidentate diazeniumdiolate conjugated 1H-pyrrole 1-oxide-oxazoline. The structure...
A series of novel dipeptidyl boronic acid compounds were designed, synthesized and biologically investigated for the inhibition β5 subunit 20S proteasome several showed high activities with IC50 values less than 10 nM. Some these potently inhibited multiple myeloma (MM) cancer cell lines It was reported that both β2 subunits strongly increased cytotoxicity inhibitors in solid tumor cells, so some evaluated triple-negative breast line MDA-MB-231. The results three active vivo pharmacokinetic...
Serious bacterial infections by multi-drug-resistant pathogens lead to human losses and endanger public health. The discovery of antibiotics with new modes action, in combination nanotechnology, might offer a promising route combat pathogens. Platensimycin (PTM), potent inhibitor FabB/FabF for fatty acid biosynthesis, is drug against many drug-resistant bacteria. However, the clinical development PTM hampered its poor pharmacokinetics. Herein, we report nanostrategy that encapsulated two...
Gastric ulcer is one of the most common gastrointestinal diseases, and natural products have obvious advantages in treatment diseases. Baicalin (Bai) extracted from scutellaria baicalensis exhibits anti-inflammatory, antioxidant, anti-apoptotic activities. Herein, a pH-responsive sodium alginate/polyaspartate/CaCO3 (SA/PASP@CaCO3) situ hydrogel was established for oral delivery Bai. In this study, we detected gelling properties, mechanical strength, vitro erosion, release behavior hydrogels....
Preparation of MF-FA nanoparticles and the release behavior drugs in tumor cells.
The purpose of this study was to evaluate the efficacy ethanol extracts from Torreya grandis seed (EST) as a functional food in hyperuricemia mice. We investigated EST by analyzing its chemical composition. Using mouse model induced potassium oxonate (PO), we evaluated effects on uric acid (UA) production, inflammation-related cytokines, and gut microbiota diversity. primary constituents consist various flavonoids phenolic compounds known for their antioxidant anti-inflammatory properties...
Triple‐negative breast cancer (TNBC) is an aggressive subtype, which has poor prognosis due to the lack of effective targeted drugs. KPT‐330, inhibitor nuclear export protein CRM‐1, been widely used in clinical medicine. Y219, a novel proteasome designed by our group, shows superior efficacy, reduced toxicity, and off‐target effects as compared bortezomib. In this study, we investigated synergistic effect KPT‐330 Y219 against TNBC cells, well underlying mechanisms. We report that combination...
Abstract Objectives The rapid development of drug-resistant bacteria, especially MRSA, poses severe threats to global public health. Adoption antibiotic adjuvants has proved be one the efficient ways solve such a crisis. Platensimycin and surfactin were comprehensively studied combat prevalent MRSA skin infection. Methods MICs platensimycin, or their combinations determined by resazurin assay, while corresponding MBCs chequerboard assay. Growth inhibition curves biofilm OD measurements....