A5024171694- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Graphene and Nanomaterials Applications
- Proteoglycans and glycosaminoglycans research
- Advanced Polymer Synthesis and Characterization
- Invertebrate Immune Response Mechanisms
- Single-cell and spatial transcriptomics
- Spinal Cord Injury Research
- Polysaccharides and Plant Cell Walls
- Extracellular vesicles in disease
- Physiological and biochemical adaptations
- Photodynamic Therapy Research Studies
- Medicinal Plants and Bioactive Compounds
- Advanced Breast Cancer Therapies
- Ginkgo biloba and Cashew Applications
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Synthesis and Catalytic Reactions
- Photochromic and Fluorescence Chemistry
Nanjing Drum Tower Hospital
2021-2025
Nanjing University
2024
BGI Research
2022-2023
Nanjing Medical University
2023
Dalian Medical University
2020-2023
BGI Group (China)
2023
Botswana Geoscience Institute
2022
Nantong University
2020
Second Affiliated Hospital of Dalian Medical University
2020
China Pharmaceutical University
2018-2019
Abstract Although stem cell‐based therapy is recognized as a promising therapeutic strategy for spinal cord injury (SCI), its efficacy greatly limited by local reactive oxygen species (ROS)‐abundant and hyper‐inflammatory microenvironments. It still challenge to develop bioactive scaffolds with outstanding antioxidant capacity neural cells (NSCs) transplantation. In this study, albumin biomimetic cerium oxide nanoparticles (CeO 2 @BSA nanoparticles, CeNPs) are prepared in simple efficient...
Multidrug resistance (MDR) remains one of the major reasons for inefficiency many chemotherapeutic agents in cancer therapy. In this study, a D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and polylysine-deoxycholic acid copolymer (PLL-DA) co-modified cationic liposome coating with hyaluronic (HA) was constructed co-delivery paclitaxel (PTX) chemosensitizing agent, sorafenib (SOR) to treat MDR cancer. The multifunctional (HA-TPD-CL-PTX/SOR) presented good stability against rat...
Background: The combination of novel starving therapy with chemotherapy is one the most promising strategies to achieve an effective antitumor activity. Methods: Herein, we developed a multifunctional mesoporous silica nanoparticle (MSNs-GOx/PLL/HA) coated poly (L-lysine) (PLL) and hyaluronic acid (HA) for co-delivery glucose oxidase (GOx) anticancer drug paclitaxel (PTX) cancer treatment first time. Compared single chemotherapy, introduction GOx would not only selectively trigger...
Tumors are one of the main diseases threatening human life and health. The emergence nanotechnology in recent years has introduced a novel therapeutic avenue for addressing tumors. Through amalgamation nanotechnology's inherent attributes with those natural enzymes, nanozymes have demonstrated ability to initiate catalytic reactions, modulate biological microenvironment, facilitate adoption multifaceted approaches, thereby exhibiting considerable promise realm cancer treatment. In this...
The lack of effective oral drug delivery systems to treat gastric ulcer is an urgent challenge in clinical practice. Herein, a acid pH-responsive hydrogel curcumin/sodium alginate/polyaspartic acid@CaCO3 (Cur/SA/PC) was developed for sustained release Cur, exerting protection and treatment ulcers. vitro gelatinization properties the corresponding gel characteristics SA/PC system demonstrated successful construction situ with uniform strength. cellular uptake illustrated Cur. Besides, Cur...
Gastric ulcer is one of the most common gastrointestinal diseases, and natural products have obvious advantages in treatment diseases. Baicalin (Bai) extracted from scutellaria baicalensis exhibits anti-inflammatory, antioxidant, anti-apoptotic activities. Herein, a pH-responsive sodium alginate/polyaspartate/CaCO3 (SA/PASP@CaCO3) situ hydrogel was established for oral delivery Bai. In this study, we detected gelling properties, mechanical strength, vitro erosion, release behavior hydrogels....
The capillarization of hepatic sinusoids resulting from the activation stellate cells poses a significant challenge, impeding effective delivery therapeutic agents to Disse space for liver fibrosis treatment. Therefore, overcoming these barriers and achieving efficient drug activated (aHSCs) are pressing challenge. In this study, we developed synergistic sequential approach utilizing neutrophil membrane hybrid liposome@atorvastatin/amlisentan (NCM@AtAm) vitamin A-neutrophil liposome @albumin...
Preparation of MF-FA nanoparticles and the release behavior drugs in tumor cells.
Design and manufacture of an ultra-small bionic multifunctional nanozyme BSA@CNP/Fe 2+ as a radiosensitizer to treat breast cancer.
Purpose The risk of brain exposure to ionizing radiation increases gradually due the extensive application nuclear technology in medical, industrial, and aerospace fields. Radiation-induced injury (RBI) is highly likely cause a wide range neurological complications, including schizophrenia, Alzheimer's disease (AD), depression. Ginkgolide B (GB) one effective active components extracted from ginkgo biloba leaves, exerts protective effects on CNS, which involved regulation Hippo signaling...
Precise regulation of stem cell activity is crucial for tissue homeostasis. In Drosophila, intestinal cells (ISCs) maintain the midgut epithelium and respond to oxidative challenges. However, connection between homeostasis redox signaling remains obscure. Here we find that Caliban (Clbn) functions as a regulator mitochondrial dynamics in enterocytes (ECs) required The clbn knock-out flies have shortened lifespan lose Clbn highly expressed localizes outer membrane mitochondria ECs....
Background. Pyroptosis is closely related to the programmed death of cancer cells as well tumor immune microenvironment (TIME) via host-tumor crosstalk. However, role pyroptosis-related genes prognosis and TIME-related biomarkers in skin cutaneous melanoma (SKCM) patients remains unknown. Methods. We evaluated expression profiles, copy number variations, somatic mutations (CNVs) 27 obtained from MSigDB database regulating pyroptosis among TCGA-SKCM patients. Thereafter, we conducted...
The six species of lungfish possess both lungs and gills are the closest extant relatives tetrapods. Here, we report a single-cell transcriptome atlas West African (Protopterus annectens). This manifests most extreme form terrestrialization, life history strategy to survive dry periods that can last for years, characterized by dormancy reversible adaptive changes lungs. Our highlights cell type diversity lungfish, including gene expression consistent with phenotype terrestrialization....
ABSTRACT The development of novel thermo‐ and photo‐dual‐responsive biodegradable polymeric micelles based on amphiphilic polyaspartamide derivatives (NB ‐g‐ PHPA mPEG) for anticancer drug delivery is reported. obtained polymers containing hydrophobic photocleavable o ‐nitrobenzyl groups exhibit photosensitivity. paclitaxel‐loaded the photo‐dual‐sensitive were prepared by a quick heating method without using toxic organic solvent. paclitaxel release from drug‐loaded can be triggered under...
Abstract Long noncoding RNAs (lncRNAs) play important regulatory roles in stem cell self-renewal, pluripotency maintenance, and differentiation. Till now, there is very limited knowledge about how lncRNAs regulate intestinal cells (ISCs), mediating ISC regeneration Drosophila have yet been characterized. Here, we identify a lncRNA, CR46040, that essential for the injury-induced Drosophila. Loss of CR46040 greatly impairs proliferation response to tissue damage caused by dextran sulfate...
A novel and efficient preparation of epoxyketone intermediates for the synthesis carfilzomib its derivatives has been developed. Compared to reported methods, this highly stereoselective, environmentally friendly, low-cost method can be used in scaling up derivatives.
Abemaciclib is an effective selective cyclin-dependent kinases 4 and 6 inhibitors for cancer therapy. The abemaciclib-related substances influence its efficacy safety, are important in process preparation studies quality control. Thus, a reversed-phase high-performance liquid chromatography method was developed validated the detection of related bulk drug. separation abemaciclib performed on Phenomenon Gemini C18 column (4.6 × 250 mm, 5 μm) with flow rate 1.0 ml/min. ultraviolet wavelength...