A5102892547- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Computational Drug Discovery Methods
- RNA Research and Splicing
- MicroRNA in disease regulation
- Inflammatory Bowel Disease
- Extracellular vesicles in disease
- Circular RNAs in diseases
- RNA regulation and disease
- Eosinophilic Esophagitis
- Epigenetics and DNA Methylation
- Aquaculture disease management and microbiota
- Cell Adhesion Molecules Research
- Mitochondrial Function and Pathology
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Galectins and Cancer Biology
- Glycogen Storage Diseases and Myoclonus
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Venous Thromboembolism Diagnosis and Management
Liaocheng People's Hospital
2017-2025
Weatherford College
2022-2023
Human Factors (Norway)
2023
Eastern Hepatobiliary Surgery Hospital
2020
Second Military Medical University
2020
Henan Provincial People's Hospital
2019
Henan University
2019
Chinese Academy of Sciences
2017-2018
Beijing Institute of Genomics
2017-2018
Harbin Medical University
2013-2017
Rationale: Long extracellular RNAs (exRNAs) in plasma can be profiled by new sequencing technologies, even with low abundance. However, cancer-related exRNAs and their variations remain understudied. Methods: We investigated different (i.e. differential expression, alternative splicing, polyadenylation, editing) diverse long exRNA species (e.g. noncoding circular RNAs) using 79 exosomal RNA-seq (exoRNA-seq) datasets of multiple cancer types. then integrated 53 exoRNA-seq 65 self-profiled...
Lampreys are early jawless vertebrates that the key to understanding evolution of vertebrates. However, lack cytomic studies on multiple lamprey organs has hindered progress in this field. Therefore, present study constructed a comprehensive cell atlas comprising 604,460 cells/nuclei and 70 types from 14 tissue samples. Comparison cellular across species revealed most homologous those jawed We discovered acinar- islet-like populations despite parenchymal lampreys, providing evidence...
Drug repositioning, also known as drug repurposing or reprofiling, is the process of finding new indications for established drugs. Because repositioning can reduce costs and enhance efficiency development, it paramount importance in medical research. Here, we present a systematic computational method to identify potential novel given drug. This utilizes some prior knowledge such 3D chemical structure information, drug–target interactions gene semantic similarity information. Its prediction...
Albinism, a phenomenon characterized by pigmentation deficiency on the ocular side of Japanese flounder (Paralichthys olivaceus), has caused significant damage. Limited mRNA and microRNA (miRNA) information is available fish deficiency. In this study, high-throughput sequencing strategy was employed to identify miRNAs involved in P. olivaceus albinism. Based genome, RNA-seq identified 21,787 know genes 711 new transcripts assembly. Of those, 235 exhibited significantly different expression...
Abstract Accumulating evidences highlight the critical roles of long noncoding RNAs (lncRNAs) in a variety cancers. LncRNA PXN‐AS1‐L was previously shown to exert oncogenic hepatocellular carcinoma. However, expression, role, and molecular mechanism nasopharyngeal carcinoma (NPC) malignancy remain unknown. Here, we determined that is upregulated NPC tissues cell lines. Increased expression predicts worse prognosis patients. overexpression promotes proliferation, migration, invasion vitro,...
Objectives This study aimed to identify key genes related copper metabolism in Parkinson's disease (PD), providing insight into their roles progression.
Atherosclerosis (AS) is a multifactorial disease. Exploration of DNA methylation in regulating gene transcription cell type- and stage-specific manner will shed light on understanding the biological processes associated with plaque stability. We identified 174 up-regulated genes hypo-methylation promoter, 86 down-regulated hyper-methylation AS vs. healthy controls. Among them, high expression signaling lymphocytic activation molecule 7 (SLAM7) was examined carotid intact tissue, advanced...
Adverse drug reactions (ADRs) are caused by interactions between drugs or their metabolites and specific proteins. Knowledge of these proteins is important for facilitating mechanistic research ADRs new discovery. Here, we identified 41 network modules from an ADR-protein network; analysed the function each module; revealed potential accompanying actions ADR-related (ADRPs) to a unique ADR studied characteristics composition, subcellular location tissue distribution ADRPs comparing them with...
Carotid atherosclerotic plaques are the manifestation of atherosclerosis in carotid arteries and can significantly increase incidence cerebrovascular disease. Macrophages smooth muscle cells crucial for their development. To reveal mechanism plaque formation, we performed single-nucleus RNA sequencing tissue identified 11 cell types, macrophages were divided into 5 different macrophage subpopulations. The patients with symptomatic caused intraplaque death via mitochondrial autophagic...
Rationale: Lung tumors arise from the unrestrained malignant growth of pulmonary epithelial cells. cancer cases include both small and non-small cell lung cancers, with adenocarcinoma (LUAD) accounting for roughly half all cases. Research focused on familial cancers suggests that approximately 8% are linked to genetic susceptibility or heritability. The precise factors underlie onset cancer, however, remain be firmly established. Patient concerns: A 43-year-old presented nodules in lower...
The six species of lungfish possess both lungs and gills are the closest extant relatives tetrapods. Here, we report a single-cell transcriptome atlas West African (Protopterus annectens). This manifests most extreme form terrestrialization, life history strategy to survive dry periods that can last for years, characterized by dormancy reversible adaptive changes lungs. Our highlights cell type diversity lungfish, including gene expression consistent with phenotype terrestrialization....
Clinical manifestations of the late-onset adult Pompe disease (glycogen storage type II) are heterogeneous. To identify genetic defects a special patient population with cerebrovascular involvement as main symptom, we performed whole-genome sequencing (WGS) analysis on consanguineous Chinese family total eight members including two siblings both had cerebral infarction. Two novel compound heterozygous variants were found in GAA gene: c.2238G>C exon 16 and c.1388_1406del19 9 patients. We...
Abstract Rivaroxaban is an oral anticoagulant that inhibits thrombin and blocks coagulation cascade through directly inactivating factors Xa. Despite rivaroxaban widely used for prevention treatment of venous thrombosis, its common adverse reactions have been reported, including abnormal coagulation, mucosal hemorrhage, hematuria, intracranial hemorrhage. To explore potential drivers individual differences in induced by rivaroxaban, we performed whole‐exome sequencing found AKR7A3...
<title>Abstract</title> Chronic obstructive pulmonary disease (COPD) is a prevalent and progressive form of respiratory in which patients exhibit persistent damage affecting the alveoli and/or airway due to exposure toxic gases or particulate matter. The best-studied risk factor associated with COPD incidence cigarette smoke. C57BL/6 mice were exposed smoke lipopolysaccharide establish model, followed by scATAC sequencing scRNA lung tissue samples. resultant data revealed consistent findings...
Introduction Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder marked by persistent respiratory symptoms and escalating airflow obstruction. The global rise in COPD incidence mortality poses significant societal burden. Despite its prevalence, the intricate pathogenesis of remains incompletely understood. This study aims to elucidate molecular markers potential therapeutic targets integrating known COPD-related genes analyzing RNA-Seq expression microarray data....
Primary open-angle glaucoma (POAG) is a subtype of that accounts for 60%~70% all cases. Its pathogenic mechanism intricate and its process concealed. Numerous significant biological processes associated with POAG continue to be elucidated.
Identifying the occurrence mechanism of drug-induced side effects (SEs) is critical for design drug target and new development. The expression genes in biological processes regulated by transcription factors(TFs) and/or microRNAs. Most previous studies were focused on a single level gene or sets, while about regulatory relationships TFs, miRNAs are very rare. Discovering complex regulating relations among sets will be helpful researchers to get more comprehensive understanding reaction. In...
Interstitial lung disease (ILD) is a severe manifestation of rheumatoid arthritis (RA), which characterized by low survival time post-diagnosis. Thus, it important to explore the role gene regulation related with ILD.Constructed RA-ILD-related long chain noncoding RNA - messenger (lncRNA-mRNA) network (ILD-LMN), based on ILD- and RA-related genes. We analyzed topological properties resulting network.The results for modularization functional analysis showed that ILD-LMN performed basic...