A5100358837- Cardiovascular Health and Disease Prevention
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Migraine and Headache Studies
- Heart Rate Variability and Autonomic Control
- Cerebrovascular and Carotid Artery Diseases
- Heat shock proteins research
- Anesthesia and Pain Management
- Connexins and lens biology
- Anesthesia and Sedative Agents
- China's Socioeconomic Reforms and Governance
- Cardiac Structural Anomalies and Repair
- Inflammasome and immune disorders
- Sleep and related disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac tumors and thrombi
- Transcranial Magnetic Stimulation Studies
- Nausea and vomiting management
- Inflammatory Biomarkers in Disease Prognosis
- Chemokine receptors and signaling
- Dispute Resolution and Class Actions
- Fluoride Effects and Removal
- Protein Structure and Dynamics
- Ophthalmology and Visual Health Research
Second Hospital of Shandong University
2025
Shandong University of Traditional Chinese Medicine
2025
Guangxi University of Chinese Medicine
2024
Taiyuan University of Technology
2024
Guizhou University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2023
Chinese PLA General Hospital
2023
National Clinical Research
2023
Peking Union Medical College Hospital
2010-2023
The First People's Hospital of Changde
2023
Functions of astrocytes in the rehabilitation after ischemic stroke, especially their impacts on inflammatory processes, remain controversial. This study uncovered two phenotypes astrocytes, which one was helpful, and other harmful to anoxic neurons brain ischemia. We tested levels factors including TNF-a, IL-6, IL-10, iNOS, IL-1beta, CXCL10 primary at 0 h, 6 12 24 48 h OGD, grouped hypoxia into iNOS-positive (iNOS(+)) iNOS-negative (iNOS(−)) by magnetic bead sorting, then co-cultured groups...
(1) Background: Rhubarb anthraquinones-a class of components with neuroprotective function-can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and infarction area; UPLC-MS/MS was in pharmacokinetic studies detect plasma concentrations at different time points, DAS software calculate parameters a noncompartmental model. (3) Results: results showed that the pharmacodynamics...
<title>Abstract</title> <bold>Objective</bold> Postoperative sleep disturbance (PSD) is a common problem in elderly patients, affecting postoperative recovery and potentially increasing the risk of complications. Esketamine an N-methyl-D-aspartate (NMDA) receptor antagonist that has potential to improve sleep. The aim this randomized controlled trial evaluate impact intraoperative infusion sub-anesthetic doses esketamine on PSD patients undergoing laparoscopic gastrointestinal tumor...
The bark, leaves, and flowers of Paulownia trees have been used in traditional Chinese medicine to treat infectious inflammatory diseases. We investigated the antiviral effects tomentosa flowers, an herbal some provinces P. R. China for treatment skin rashes blisters. Dried were extracted with methanol tested activity against enterovirus 71 (EV71) coxsackievirus A16 (CAV16), predominant etiologic agents hand, foot, mouth disease China. extract inhibited EV71 infection, although no effect was...
Background and Purpose— Platelet aggregation plays a vital role in the development of in-stent restenosis (ISR) after carotid angioplasty stenting (CAS). Mean platelet volume (MPV) has been suggested as an index reactivity. This study aimed to investigate association between MPV ISR CAS patients. Methods— A total 261 patients with were enrolled. was measured before procedure. Digital subtraction angiography, computed tomographic or duplex ultrasonography performed at 6 months annually...
Aging is a known risk factor of idiopathic pulmonary fibrosis (IPF). However, the pathogenic mechanisms underlying effects advanced aging remain largely unknown. Telomeric repeat-containing RNA (TERRA) represents type long noncoding RNA. In this study, regulatory roles TERRA on human telomeres and mitochondria IPF epithelial injury model were identified. Blood samples collected from patients with (n = 24) matched control individuals 24). The significance clinical research expression...
Oligodendrocytes express low-density lipoprotein receptor (LDLR) to endocytose cholesterol for the maintenance of adulthood myelination. However, potential role LDLR in chronic cerebral ischemia-related demyelination remains unclear. We used bilateral carotid artery stenosis (BCAS) induce sustained ischemia mice. This hypoxic-ischemic injury caused a remarkable decrease oligodendroglial LDLR, with impaired differentiation and survival. Oligodendroglial levels, however, remained unchanged....
Abstract Background: The current study examined the role(s) of autophagy in myotoxicity induced by bupivacaine mouse myoblast C2c12 cells. Methods: cells were treated with bupivacaine. Myotoxicity was evaluated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (n = 3 to 30), live/dead 4), and morphological alterations 3). Autophagosome formation reflected microtubule-associated protein light chain conversion 4 12) punctation 5). clearance p62 level 4) autolysosomes...
Abstract Heat shock protein A12B ( HSPA 12B) is a newly discovered member of the HSP 70 family. This study investigated effects 12B on lipopolysaccharide LPS )‐induced inflammatory responses in human umbilical vein endothelial cells HUVEC s) and possible mechanisms involved. A s model was induced by . Overexpression achieved infection with recombinant adenoviruses encoding green fluorescence protein‐ 12B. Knockdown si RNA technique. Twenty four hours after virus or transfection, were...
The inflammatory response plays a vital role in the development of in-stent restenosis (ISR) after carotid angioplasty and stenting (CAS). neutrophil to lymphocyte ratio (NLR) has been suggested as sensitive marker. We explored association between NLR ISR CAS patients. A total 427 patients who underwent were enrolled. Neutrophil was measured before procedure. Clinical examination radiographic evaluation performed at 6 months annually In-stent defined ≥50% stenosis treated lesion. Cox...
Genistein has beneficial effects on metabolic disorders. However, the specific mechanism is not clearly understood. In light of significant role hypothalamus in energy and homeostasis, this study was designed to explore whether dietary genistein intake could mitigate harmful a high-fat diet glucose lipid metabolism any alterations caused by were associated with hypothalamic gene expression profiles. C57BL/6 female mice fed without (HF), (HFG), or normal control (CON) for 8 weeks. Body weight...
Magnetic nanoparticles SPIONs are non-invasively introduced into the brain to enhance effects of a non-invasive clinical stimulation method for treating neurological disorders.
In recent years, studies have demonstrated that vascular endothelial growth factor B (VEGFB) can affect the metabolism of fatty acids and glucose, it is expected to become a target for diagnosis treatment metabolic diseases such as obesity diabetes. At present, specific mechanism VEGFB regulates lipid glucose balance not completely understood. The present study used systemic gene‑knockout mice investigate effects downregulation gene on insulin secretion, explore pathway involved in...
This research investigates adverse drug events (ADEs) linked to trametinib, utilizing data from the FDA Adverse Event Reporting System (FAERS) database, covering period Q2 2013 Q4 2023.
Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. Proliferating cell nuclear antigen (PCNA) plays pivotal role in cancer development and progression. However, the long‐term dismal prognosis HCC mandates more investigation to identify novel regulators pathogenesis. Heat‐shock protein A12A (HSPA12A) encodes member HSP70 family. Here, we report that cells showed increased HSPA12A expression, overexpression promoted growth angiogenesis mice. Gain‐ loss‐of‐functional...
<sec><strong>OBJECTIVE</strong> To evaluate the associations of lipid indicators and mortality in Beijing Elderly Comprehensive Health Cohort Study. </sec><sec><strong>METHODS</strong> A prospective cohort was conducted based on Study with 4499 community older adults. After baseline survey, last follow-up March 31, 2021 an average 8.13 years follow-up. Cox proportional hazard model used to estimate ratios (HR) 95% CI for cardiovascular disease (CVD) death all-cause indicators....