A5020158495- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- RNA modifications and cancer
- Cancer-related gene regulation
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Extracellular vesicles in disease
- ATP Synthase and ATPases Research
- Single-cell and spatial transcriptomics
- Spinal Fractures and Fixation Techniques
- 3D Printing in Biomedical Research
- Cancer Research and Treatments
- Nerve injury and regeneration
- Redox biology and oxidative stress
- Signaling Pathways in Disease
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related Molecular Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Brain Metastases and Treatment
- Cancer Cells and Metastasis
- Stress Responses and Cortisol
- Histone Deacetylase Inhibitors Research
Binzhou University
2017-2025
Binzhou Medical University
2017-2025
CHA Bundang Medical Center
2024-2025
CHA University
2024-2025
Catholic University of Korea
2023-2025
Yantai Institute of Coastal Zone Research
2019
Chinese Academy of Sciences
2019
Taishan Medical University
2016-2017
Xi'an Medical University
2017
Abstract Background Although meningioma is the most common primary brain tumor, treatments rely on surgery and radiotherapy, recurrent meningiomas have no standard therapeutic options due to a lack of clinically relevant research models. Current cell lines or organoids cannot reflect biological features patient tumors since they undergo transformation along culture consist only tumor cells without microenvironment. We aim establish patient-derived (MNOs) preserving diverse types...
Osteoporotic vertebral compression fractures (OVCFs) significantly increase morbidity and mortality, presenting a formidable challenge in healthcare. Traditional interventions such as vertebroplasty kyphoplasty, despite their widespread use, are limited addressing the secondary effects of adjacent areas do not facilitate bone regeneration. This review paper explores emerging domain regenerative therapies, spotlighting stem cell therapy’s transformative potential OVCF treatment. It thoroughly...
Abstract Emerging evidence suggests that microRNA (miRNA) and long noncoding RNA (lncRNA) play important roles in disease development. However, the mechanism underlying mRNA interaction with miRNA lncRNA idiopathic pulmonary fibrosis (IPF) remains unknown. This study presents a novel lnc-PCF promotes proliferation of TGF- β 1-activated epithelial cells through regulation map3k11 by directly targeting miR-344a-5p during fibrogenesis. Bioinformatics vitro translation assay were performed to...
Fibroblast-to-myofibroblast differentiation is the main cytopathologic characteristic of pulmonary fibrosis. However, its underlying molecular mechanism remains poorly understood. This study elucidated that nuclear export lncNONMMUT062668.2 (lnc668) exacerbated fibrosis by activating fibroblast-to-myofibroblast differentiation. Mechanistic research revealed histone H3K9 lactylation in promoter region N6-methyladenosine (m6A) writer METTL3 was enriched to enhance transcription, leading lnc668...
Several recent studies have indicated that miR-30a plays critical roles in various biological processes and diseases. However, the mechanism of participation idiopathic pulmonary fibrosis (IPF) regulation is ambiguous. Our previous study demonstrated may function as a novel therapeutic target for lung by blocking mitochondrial fission, which dependent on dynamin-related protein1 (Drp-1). regulatory between Drp-1 yet to be investigated. Additionally, whether can act potential has not been...
Aging is a known risk factor of idiopathic pulmonary fibrosis (IPF). However, the pathogenic mechanisms underlying effects advanced aging remain largely unknown. Telomeric repeat-containing RNA (TERRA) represents type long noncoding RNA. In this study, regulatory roles TERRA on human telomeres and mitochondria IPF epithelial injury model were identified. Blood samples collected from patients with (n = 24) matched control individuals 24). The significance clinical research expression...
Glutathione hydropersulfides (GSSH) are alluded to play crucial roles in signal transduction, redox homeostasis, and metabolic regulation. However, the detailed biological functions of GSSH these aspects extremely ambiguous. The key barrier understand role systems is a lack detection tools with high spatiotemporal resolution. To address issues, we seeking novel chemical for detection. We herein develop first two-photon ratiometric fluorescent probe (TP-Dise) spatial temporal resolution...
<title>Abstract</title> Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia of unknown etiology. Abnormal regulation the cytoskeleton key factor driving fibrogenesis. However, molecular mechanisms remodeling in remains obscure. Methods Succinylome analysis lung tissues from bleomycin (BLM)-treated mice was performed. Key modified proteins and sites were identified through Clusters Orthologous Groups (COG) functional classification...
Abstract Background Despite advancements in targeted therapy and immunotherapy, cutaneous melanoma continues to have a high mortality rate poor prognosis, with therapies having limited efficacy advanced melanoma. Therefore, it is crucial develop novel therapeutics proven clinical potential. In this study, we evaluated the of arcyriaflavin A (ArcA), potent inhibitor cyclin D1/CDK4 complex, suppressing aggressive phenotypes metastatic Methods The effects ArcA on viability cell cycle were...
Context In clinical practice, the promotion of neuron survival is necessary to recover neurological functions after onset stroke. Objective This study aimed investigate post-ischaemic neuroprotective effect SMND-309, a novel metabolite salvianolic acid, on differentiated SH-SY5Y cells. Materials and methods cells were by pre-treating with 5 μM all-trans-retinoic acid for 6 d. The exposed oxygen-glucose deprivation (OGD) 2 h reperfusion (R) 24 induce OGD/R injury. After OGD injury, treated or...
Idiopathic pulmonary fibrosis (IPF) is considered as a chronic, fibrosing interstitial pneumonia with unknown mechanism. The present work aimed to explore the function, biogenesis and regulatory mechanism of circELP2 in evaluate value blocking circELP2-medicated signal pathway for IPF treatment. results showed that heterogeneous nuclear ribonucleoprotein L initiated reverse splicing resulting increase generation. biogenetic activated abnormal proliferation migration fibroblast extracellular...
Pulmonary fibrosis is a chronic and irreversible progressive lung disease caused by various factors, such as age environmental pollution. With countries stepping into an aging society the seriousness of pollution global industrialization, incidence pulmonary annually increasing. However, no effective drug available for treatment. C-phycocyanin (C-PC), extracted from blue-green algae, has good water solubility antioxidation. This study elucidated that C-PC reinforces autophagy to block...
Several recent studies have indicated that miR-30a plays critical roles in various biological processes and diseases. However, the mechanism of participation regulation idiopathic pulmonary fibrosis (IPF) is ambiguous. Our previous study demonstrated may function as a novel therapeutic target for lung fibrosis by blocking mitochondrial fission, which dependent on dynamin-related protein-1 (Drp-1). regulatory between Drp-1 has yet to be investigated. In addition, whether can act potential not...
Objectives The molecular mechanisms by which stress leads to the development of tinnitus are not yet well understood. This study aimed identify brain changes in a stress‐induced (ST) animal model through transcriptome analysis prefrontal lobe and hippocampus. Methods Twenty Sprague–Dawley rats were subjected restraint for 2 h. Following gap prepulse inhibition acoustic startle (GPIAS) reflex test assess development, lobes hippocampi brains harvested from 15 rats: five with evident (ST),...
Although surgery followed by platinum-based therapy is effective as a standard treatment in the early stages of ovarian cancer, majority cases are diagnosed at advanced stages, leading to poor prognosis. Thus, identification novel therapeutic drugs needed. In this study, we assessed effectiveness bepridil-a calcium channel blocker-in cancer cells using two cell lines: SKOV-3, and SKOV-3-13 (a highly metastatic clone SKOV-3). Treatment these lines with bepridil significantly reduced...