A5048009965- Bone health and osteoporosis research
- Bone health and treatments
- Ovarian cancer diagnosis and treatment
- Bone fractures and treatments
- Flavonoids in Medical Research
- Bone Metabolism and Diseases
- Hedgehog Signaling Pathway Studies
- Mesenchymal stem cell research
- Catalytic Processes in Materials Science
- Phytochemistry and Biological Activities
- Cancer Cells and Metastasis
- Nanomaterials for catalytic reactions
- Heat shock proteins research
- Renal and related cancers
- Endometrial and Cervical Cancer Treatments
- Genetic and Kidney Cyst Diseases
- Extracellular vesicles in disease
- Retinal Development and Disorders
- 3D Printing in Biomedical Research
- Cell death mechanisms and regulation
- Protein Degradation and Inhibitors
- Parathyroid Disorders and Treatments
- Neurological Disorders and Treatments
- Liver physiology and pathology
- Synthesis of Tetrazole Derivatives
Shanghai University of Medicine and Health Sciences
2024
Shanghai Ship and Shipping Research Institute
2024
Guangzhou University of Chinese Medicine
2024
Heze Municipal Hospital
2019-2023
Nanjing University
2010-2022
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
State Administration of Traditional Chinese Medicine of the People's Republic of China
2018-2021
Southern Medical University
2018-2021
University of Pennsylvania
2021
Oxidative stress plays an important role in cardiac diseases, which has been well demonstrated, whereas the of reductive poorly investigated. We and others have shown previously that heat shock protein 27 (Hsp27) a as antioxidant. To investigate whether overexpression Hsp27 could lead to result cardiomyopathy, we generated transgenic mice with different expression levels Hsp27. observed high developed cardiomyopathy. The myopathic hearts were under stress, was evidenced by increased ratio...
Abstract Background The objective of this study was to evaluate the effect bone marrow mesenchymal stem cells (BMSCs) on apoptosis granulosa (GCs) in rats. BMSCs and GCs were isolated from separated into one following three groups: an untreated control group (control), a cisplatin (5 mg/L) treatment (cisplatin), co-cultured with treated (BMSC). GC analyzed by annexin V staining real-time PCR analysis for apoptosis-related genes. also determined 9 10 month-old perimenopausal rats that saline...
The global burden of cancer remains a major public health challenge, with Kirsten rat sarcoma viral oncogene homolog (KRAS) emerging as the most common mutated across diverse malignancies. Once considered “undruggable” due to its unique structure, KRAS has garnered intense research focus, resulting in significant advancements. This paper aims review recent developments our understanding biology, including structural and functional aspects, explore latest insights into mutations various...
The purpose of this study was to determine if human parathyroid hormone-(1-38) (hPTH(1-38)) can restore cancellous bone mass the established osteopenic, immobilized proximal tibial metaphyses female rats. right hindlimbs 6-month-old Sprague-Dawley rats were by bandaging abdomen. After 30 days hindlimb immobilization, subcutaneously injected with 200 micrograms hPTH(1-38)/kg/day for 15 (short-term treatment) or 75 (longer-term treatment). Static histomorphometry performed on primary...
Elevated expression of Survivin correlates with poor prognosis, tumor recurrence, and drug resistance in various human cancers, including non-small cell lung cancer (NSCLC). The underlying mechanism upregulation cells remains elusive. To date, no Survivin-targeted therapy has been approved for treatment. Here, we explored the molecular basis resulting overexpression NSCLC investigated antitumor activity class I HDAC inhibitor entinostat combination paclitaxel. Our data showed that...
Xihuang pill (XHP), a traditional Chinese herbal formula, has long been used as an effective agent against multiple tumors. The aim of this study is to evaluate the effects XHP on growth inhibition and apoptosis in glioblastoma U-87 MG cells. Gas chromatography-mass spectrometry (GC-MS) was performed for constituent analysis XHP. Cell viability, cell cycle arrest, generation reactive oxygen species (ROS), were measured by CCK-8 assay, PI/RNase staining, DCFH-DA TUNEL Annexin V-FITC/PI double...
Fibronectin (FN) is commonly used in the development of serum-free media for expansion mesenchymal stem cells (MSCs). This study was aimed to observe if thrombin could stimulate FN secretion by human bone marrow MSCs and investigate potential underlying mechanisms. PCR performed detect expression protease-activated receptors (PARs) MSCs. After treatment, level were observed RT-PCR, immunofluorescence staining ELISA, respectively, activation ERK1/2 NF kappa B pathways revealed Western...
Early detection and prediction of prognosis treatment responses are all the keys in improving survival ovarian cancer patients. This study profiled an progression model to identify prognostic biomarkers for Mouse surface epithelial cells (MOSECs) can undergo spontaneous malignant transformation vitro cell culture. These were used as a alterations gene expression signaling detected using Illumina HiSeq2000 Next-Generation Sequencing platform bioinformatical analyses. The differential four...