A5070402121- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Advanced MRI Techniques and Applications
- Retinoids in leukemia and cellular processes
- Genomics, phytochemicals, and oxidative stress
- Immunotherapy and Immune Responses
- Antioxidant Activity and Oxidative Stress
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Plant biochemistry and biosynthesis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Energy, Environment, Economic Growth
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Energy, Environment, and Transportation Policies
- FOXO transcription factor regulation
- Arsenic contamination and mitigation
- Medicinal Plant Pharmacodynamics Research
- Microbial Community Ecology and Physiology
- DNA Repair Mechanisms
- Ultrasound Imaging and Elastography
Luoyang Normal University
2025
Hubei Provincial Women and Children's Hospital
2010-2024
Hainan Tropical Ocean University
2024
Hainan University
2023-2024
Chinese Academy of Sciences
2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023
Huazhong University of Science and Technology
2020-2023
Jiangxi University of Finance and Economics
2023
Beijing University of Chinese Medicine
2023
Huaian First People’s Hospital
2018-2022
Abstract MicroRNA‐26a‐5p (miR‐26a‐5p) has been reported to be involved in the tumorigenesis of several tumors, but its function breast cancer is still unknown. In this study, miR‐26a‐5p was found significantly downregulated both tissues and cell lines, low expression predicted a poor prognosis for patients. Overexpression could inhibit growth. Further studies revealed that overexpression protein levels Cyclin D1, CDK4, CDK6, upregulated p21, p27, p53. mechanism, targeted 3′UTR ring finger 6...
In this study, we aimed to investigate the heat tolerance mechanism in Rhododendron henanense subsp. lingbaoense (Rhl). Rhl seedlings were treated at 40℃ (RLH), 32℃ (RLM), and 24℃ (RLC), changes transcriptome metabolome compared. Overall, 78 differentially expressed metabolites detected, 8450 genes (DEGs) identified. KEGG analysis revealed that DEGs RLH vs. RLC mainly enriched photosynthesis, secondary metabolic biosynthesis, flavonoid biosynthesis. Most encoding glutathione-S-transferase...
In China, the Chinese patent drug Realgar-Indigo naturalis Formula (RIF) is utilized for therapy of acute promyelocytic leukemia (APL). Comprising four traditional herb—Realgar, Indigo naturalis, Salvia miltiorrhiza, and Pseudostellaria heterophylla—it notably includes tetra-arsenic tetra-sulfide, indirubin, tanshinone IIa, total saponins Radix Pseudostellariae as its primary active components. Due to arsenic content, RIF distinctly contributes APL. However, challenge resistance in APL...
RNF6, an E3 ligase, has been reported to play important role in the tumorigenesis several tissues, but its gastric cancer is still unknown. In this study, we aimed investigate biological function and molecular mechanisms of RNF6 cancer.The expression levels were detected by quantitative real-time PCR (qRT-PCR) immunoblotting tissues cell lines. Cell Counting Kit-8 assay was performed evaluate proliferation. apoptosis analyzed flow cytometer immunoblotting. Luciferase assay, qRT-PCR explore...
Chemokine-like factor (CKLF)-like, MAL and related proteins for vesicle trafficking membrane link (MARVEL) transmembrane domain-containing family (CMTMs) have significant roles in the immune system, male reproduction, as well tumorigenesis. Previous studies shown that CMTM member 7 (CMTM7) was broadly expressed various normal tissues, but not lung, gastric, esophageal, pancreas, cervix cancers. To explore its relationship with liver cancer, we examined expression of CMTM7 cancers correlation...
Abstract It has been reported that tripartite motif containing 26 (TRIM26) is involved in the tumorigenesis of some cancers, but its function non‐small cell lung cancer (NSCLC) still unclear. In this study, we found TRIM26 was markedly down‐regulated both NSCLC tumor tissues and lines. Additionally, high expression patients predicted a positive index for patients' overall survival. What more, overexpression significantly suppressed growth. Our further studies indicated inhibited...
Intestinal microecology (IM) is the largest and most important microecological system of human body. Furthermore, it key factor for activating maintaining physiological functions intestine. Numerous studies have investigated effects gut microbiota on different tissues organs body as well their association with various diseases, findings are gradually being translated into clinical practice. The affects occurrence, progression, treatment response, toxic side tumors. deepening research related...
Xihuang pill (XHP), a traditional Chinese herbal formula, has long been used as an effective agent against multiple tumors. The aim of this study is to evaluate the effects XHP on growth inhibition and apoptosis in glioblastoma U-87 MG cells. Gas chromatography-mass spectrometry (GC-MS) was performed for constituent analysis XHP. Cell viability, cell cycle arrest, generation reactive oxygen species (ROS), were measured by CCK-8 assay, PI/RNase staining, DCFH-DA TUNEL Annexin V-FITC/PI double...
Background and objectives: The nuclear factor kappa B (NF-κB) signaling is activated in esophageal squamous cell carcinoma (ESCC) can be used as a potential target for anti-ESCC drug discovery. In this study, we aimed to investigate the function of flubendazole novel NF-κB inhibitor ESCC cells. Materials methods: Cell Counting Kit-8 assay was carried out assess viability Flow cytometry immunoblotting were performed examine apoptosis. Immunoblotting analyze protein expression signaling....
MicroRNA-26a (miR-26a) has been reported to be involved in the tumorigenesis of several tumors, but its biological function and molecular mechanism multiple myeloma (MM) are still unknown. In this study, we found that overexpression miR-26a obviously inhibited MM cell growth, delayed tumor growth xenografts. Further studies showed induced cycle arrest at G0/G1 phase cells. MiR-26a mimic down-regulated expression levels CDK6 E2F1, up-regulated p53 p21 expression. contrast, decreased effect on...
Background and objectives: Ubiquitin-specific peptidase 28 (USP28) has been reported to play significant roles in several tumors, but its non-small-cell lung cancer (NSCLC) is still unknown.In this study, we aimed investigate the biological function molecular mechanisms of USP28 NSCLC.Materials methods: Immunoblotting analysis was used detect relative proteins' expression.Luciferase assay performed explore activation signal transducer activator transcription 3 (STAT3).Immunoprecipitation...
Abstract Background and Aim The immune modulatory drug lenalidomide has shown promising anti‐tumor activity in a clinical trial of patients with advanced hepatocellular carcinoma ( HCC ). present study explored whether can enhance the sorafenib, standard molecular targeted therapy for . Methods efficacy single‐agent or combination treatment was measured by change tumor volume animal survival using an orthotopic liver cancer model. Distribution T ‐cell subpopulations tumor‐infiltrating...
Si-B-C-N/diamond-like carbon (DLC) gradient films with different layers were prepared on a glass substrate by radio frequency magnetron sputtering, and the structure surface morphology of resulting analyzed scanning electron microscopy, Raman spectrometry, X-ray photoelectron spectroscopy. The mechanical optical properties studied using multifunctional material testing system, UV-Vis spectrophotometer, micro-Vickers hardness tester. promotes formation sp3 bonds improves transmittance films....
Second primary breast cancer (SPBC) is becoming one of the major obstacles to (BC) control. This study was aimed determine trend SPBC incidence over time and risk developing in site-specific survivors United States. The Surveillance, Epidemiology, End Results (SEER) 13 registry (1992–2015) used identify patients with previous malignancies. Standardized ratio (SIR) computed compare rates observed cases expected general population. Elevated women BC (SIR = 1.74) or thyroid 1.17). Women initial...
The c‑Src protein family of tyrosine kinases are important in the tumorigenesis many types tumors, and may be a potential target for antitumor drug discovery. In present study, immunoblotting was performed to analyze expression, CCK‑8 assay carried out assess cell viability cycle analyzed using flow cytometer. anthelmintic agent oxfendazole observed novel inhibitor that blocked activation c‑Src. Oxfendazole also suppressed growth non‑small lung cancer (NSCLC) cells, overexpression decreased...
Abstract Rationale Immune thrombocytopenia (ITP) is thought to be a result of immune dysfunction, which treated by glucocorticoids such as prednisone. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) have immunomodulatory properties, but their role in control unclear. The major goal this study was look at the effects prednisone on platelet, VIP, PACAP levels ITP mice, well regulatory system that controls immunity. Methods Eighteen BALB/c mice...
RING finger protein 38 (RNF38) has been reported to be involved in the tumorigenesis of several tumors, but its role colorectal cancer (CRC) is still not investigated. In present study, we aimed investigate effect RNF38 CRC cells.The public tumor databases GEPIA and Kaplan-Meier Plotter were used analyze expression patients' overall survival CRC. The qRT-PCR was carried out assess mRNA levels LDB1. Western blot co-immunoprecipitation detect ubiquitination. CCK-8 assay performed cell growth...
Two new fungal polyketides with unusual skeleton, collecapsins A and B (1-2), along two known macrolactins (3-4), were isolated from the rice cultures of an endophytic fungus Colletotrichum capsici obtained fresh Siegesbeckia pubescens Makino. Their structures established by a combination NMR, HRESIMS, IR analysis. The absolute configurations 1 2 determined on detailed analysis modified Mosher's derivatives' spectra its key NOEs correlations. In this case, all chiral centres for first time,...
Evidence-based Guidelines of Clinical Practice with Acupuncture and Moxibustion:Migraine (Guideline) was updated in 2014 on the basis version 2011. In Guideline version, evidence quality grade GRADE were adopted for evaluation recommendation grading methodology, clinical feasibility stressed. text, recognition modern medicine updated, sta-ging treatment acupuncture moxibustion emphasized, inclusive articles expanded important indexes efficacy increased highlighted. The paper aims to provide...