A5101783604- RNA modifications and cancer
- Cancer-related gene regulation
- Plant tissue culture and regeneration
- Geothermal Energy Systems and Applications
- Hydrocarbon exploration and reservoir analysis
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Geophysical and Geoelectrical Methods
- Geological and Geochemical Analysis
- Geological Modeling and Analysis
- Groundwater and Isotope Geochemistry
- Lipid metabolism and biosynthesis
- Methane Hydrates and Related Phenomena
- Advances in Cucurbitaceae Research
- Caching and Content Delivery
- Geological and Geophysical Studies
- CO2 Sequestration and Geologic Interactions
- Immunotherapy and Immune Responses
- Pregnancy and Medication Impact
- Monoclonal and Polyclonal Antibodies Research
- Nutritional Studies and Diet
- Peer-to-Peer Network Technologies
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Geoscience and Mining Technology
Wuhan University
2020-2025
Tianjin University
2023-2025
Zhongnan Hospital of Wuhan University
2022-2025
Luoyang Normal University
2025
Ningbo Medical Center Lihuili Hospital
2024
Ningbo University
2024
South China Normal University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2021-2024
Laboratoire de Tribologie et Dynamique des Systèmes
2024
DNA methylation is a critical epigenetic mechanism involved in key cellular processes. Its deregulation has been linked to many human cancers including esophageal squamous cell carcinoma (ESCC). This study was designed explore the whole status of ESCC and identify potential plasma biomarkers for early diagnosis. We used Infinium Methylation 450k array analyze tissues (n = 4), paired normal surrounding 4) mucosa from healthy individuals combined these with gene expression data GEO database....
Hot dry rock (HDR) is a kind of clean energy with significant potential. Since the 1970s, United States, Japan, France, Australia, and other countries have attempted to conduct several EGS (Enhanced Geothermal System) projects extract thermal by breaking through key technologies. However, up now, development HDR still in research, development, demonstration stage. An exploration borehole (with 236°C at depth 3705 m) was drilled into Triassic granite Gonghe Basin northwest China 2017....
Abstract Chondrocyte differentiation is a fundamental process during endochondral ossification. Several factors regulate maturation via the activity of downstream signaling pathways that target specific transcription and chondrocyte‐specific genes. In this study, we investigated mechanisms involved in regulation chick lower sternal chondrocyte upon stimulation by retinoic acid (RA) bone morphogenetic protein BMP2. RA‐induced Runx2 cultures over‐expression wild‐type (WT) enhanced colX...
Although there have been reports about the role of erythrocyte membrane protein band 4.1 like 3 (EPB41L3) in several types cancer, primarily non-small-cell lung carcinoma, molecular function and modulatory mechanisms EPB41L3 remain unclear. In specific, functional clinical significance esophageal squamous cell carcinoma (ESCC) has not explored to date. present study, reduced expression was demonstrated ESCC lines tissues, which due its high methylation rate. Ectopic cells inhibited...
The sleep-breathing condition obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse, which can exacerbate oxidative stress and free radical generation, thereby detrimentally impacting both motor sensory nerve function inducing muscular damage. OSA development promoted increasing proportions of fast-twitch muscle fibers in the genioglossus. Orientin, a water-soluble dietary C-glycosyl flavonoid with antioxidant properties, increased expression slow myosin heavy...
In this study, we aimed to investigate the heat tolerance mechanism in Rhododendron henanense subsp. lingbaoense (Rhl). Rhl seedlings were treated at 40℃ (RLH), 32℃ (RLM), and 24℃ (RLC), changes transcriptome metabolome compared. Overall, 78 differentially expressed metabolites detected, 8450 genes (DEGs) identified. KEGG analysis revealed that DEGs RLH vs. RLC mainly enriched photosynthesis, secondary metabolic biosynthesis, flavonoid biosynthesis. Most encoding glutathione-S-transferase...
Abstract Prenatal exposure to glucocorticoids is linked long‐term health risks in offspring, but the role of maternal gut microbiota mediating these effects remains unclear. Here, we demonstrate that prenatal prednisone therapy (PPT) humans and (PPE) rats result sex‐specific long bone dysplasia including reduced peak mass (PBM) heightened osteoporosis risk female offspring. Multi‐omics profiling fecal transplantation show PPE alters composition depletes microbial metabolite daidzein (DAI)....
BACKGROUND: Several studies demonstrated that microRNAs are stably detectable in plasma/serum and potential biomarkers for some diseases. The expression of microRNA-218 (miR-218) is downregulated esophageal cancer as reported previous research. OBJECTIVE: purpose this study to investigate whether miR-218 can be served a serum biomarker cancer. METHODS: We tested the level 106 patients with 60 healthy volunteers by RT-PCR analyzed relationship between clinical characteristics. RESULTS: was...
Abstract In order to better understand the crustal shortening and orogenic uplift in northeastern margin of Tibetan Plateau, as well geothermal resource effects formed during this process, we used ModEM software perform 3D MT imaging on broadband magnetotelluric survey points deployed at 710 Gonghe Basin its surrounding areas. The resistivity model suggests that exhibits a low–high–low overall electrical structure, with high conductivity widely distributed middle lower crust. also reveals...
e15008 Background: Cadherin-3 (CDH3), a calcium-dependent cell-cell adhesion glycoprotein, is overexpressed on lung, breast, ovarian, colorectal, pancreatic, head and neck other malignancies, but with negligible expression nonmalignant tissues, associated cancer aggressiveness, invasiveness, poor prognosis. BC3195 known as the only antibody drug conjugate (ADC) in clinical stage, targeting CDH3 payload of monomethyl auristatin E (MMAE). Methods: A phase I, open-label, first human study to...
Sepsis-associated encephalopathy (SAE) is a common complication in septic patients with higher ICU and hospital mortality adults poorer long-term outcomes. Clinical presentation may range from mild confusion to convulsions deep coma; however, little known about SAE children. We aimed retrospectively analyze the data for children sepsis, illustrate epidemiology, performance, adverse outcome, evaluate association between risk factors children.All sepsis who were admitted Department of...
Aging | doi:10.18632/aging.204742. Ye Lei, Hong-Fen Shen, Qi-Wen Li, Sheng Yang, Hong-Ting Xie, Xu-Feng Mei-Ling Chen, Jia-Wei Xia, Sheng-Chun Wang, Guan-Qi Dai, Ying Zhou, Ying-Chun Shi-Hao Huang, Dan-Hua He, Zhi-Hao Jin-Ge Cong, Xiao-Lin Lin, Tao-Yan Ai-Bing Wu, Dong Xiao, Sheng-Jun Xin-Ke Zhang, Jun-Shuang Jia