A5057972648- Hematopoietic Stem Cell Transplantation
- Gut microbiota and health
- Virus-based gene therapy research
- Clostridium difficile and Clostridium perfringens research
- COVID-19 Clinical Research Studies
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Neutropenia and Cancer Infections
- Inflammatory Biomarkers in Disease Prognosis
- Transplantation: Methods and Outcomes
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Oral health in cancer treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Pediatric health and respiratory diseases
- Dermatological and COVID-19 studies
- CNS Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Bleeding Diagnosis and Treatment
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Head and Neck Cancer Studies
- Chronic Myeloid Leukemia Treatments
Shenzhen University Health Science Center
2025
Wuhan University of Science and Technology
2020-2025
Union Hospital
2023-2025
Huazhong University of Science and Technology
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Mianyang Central Hospital
2025
Peking University
2024
The Military General Hospital of Beijing PLA
2016-2019
Chinese PLA General Hospital
2016
Fudan University
2006
Abstract Since December 2019, novel coronavirus infected pneumonia emerged in Wuhan city and rapidly spread throughout China. In severe cases, the number of platelets, their dynamic changes during treatment, platelet‐to‐lymphocyte ratio (PLR) were a concern. We sought to describe platelet feature these cases. Single‐center case series 30 hospitalized patients with confirmed disease (COVID)‐19 Huizhou municipal central hospital from January 2020 February retrospectively analyzed. Demographic,...
Background Chimeric antigen receptor T (CAR-T) cell therapy is more effective in relapsed or refractory diffuse large B lymphoma (DLBCL) than other therapies, but a high proportion of patients relapse after CAR-T owing to escape, limited persistence cells, and immunosuppression the tumor microenvironment. exhaustion major cause relapse. Epigenetic modifications can regulate activation, maturation depletion; they be applied reduce depletion, improve infiltration, promote memory phenotype...
CD7-targeted chimeric antigen receptor-T (CAR-T) cell therapy has shown great promise in the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL). In this study, we reported a case 34-year-old male patient with T-ALL who finally developed multi-line drug resistance and refractoriness after multiple lines high-intensity chemotherapy. After physician evaluation, received allogeneic hematopoietic stem transplantation (allo-HSCT). Then, The remained complete remission...
This study aimed to compare the efficacy and safety between haploidentical hematopoietic stem cell transplantation (HHCT) immunosuppressive therapy (IST) for treatment of pediatric acquired severe aplastic anemia (SAA). The clinical data 28 children with SAA treated from June 2010 October 2014 at our hospital were retrospectively reviewed. Of these patients, 18 HHCT 10 IST. median follow-up time was 23.5 months (range, 3-52 months). There no significant difference in overall survival rate...
CD19-directed chimeric antigen receptor (CAR) T cell therapy has been shown to achieve a considerably durable response in patients with refractory or relapsed B non-Hodgkin lymphomas. Most of these CARs were generated by lentivirus. With the exception Yescarta and Tecartus, few relapsed-/refractory- lymphoma have treated clinically using retroviral vector (RV). Here, we reported relapsed/refractory grade 2 follicular patient multiple chemotherapy failures, was novel CD19 CAR-T manufactured...
Intestinal microecology (IM) is the largest and most important microecological system of human body. Furthermore, it key factor for activating maintaining physiological functions intestine. Numerous studies have investigated effects gut microbiota on different tissues organs body as well their association with various diseases, findings are gradually being translated into clinical practice. The affects occurrence, progression, treatment response, toxic side tumors. deepening research related...
To explore the impact of PD-1 maintenance therapy on relapse-free survival (RFS) patients with diffuse large B-cell lymphoma (DLBCL).We retrospectively analyzed DLBCL admitted to our center between January 2018 and July 2019 who achieved complete remission (CR) after induction chemotherapy. Forty-five received inhibitor were considered treatment group. did not undergo during same period selected as control The base levels two groups similar. 2-year RFS rate was compared. correlation adverse...
In December 2022, the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became dominant in China due to its high infectivity and lower mortality rate. The risk critical illness among patients with hematologic malignancies who contracted SARS-CoV-2 was particularly high. aim this study draft a consensus facilitate effective treatments for these based on type severity disease. Following outbreak novel China, steering committee consisting experienced hematologists...
This study was purposed to investigate the therapeutic efficacy of haploidentical allogeneic hemopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia (SAA), and evaluate safety this treatment by retrospective analysis. A total 21 patients with SAA (13 cases SAA-I, 8 SAA-II) were treated allo-HSCT. Donors relatives (12 parents, 9 siblings). The conditioning regimen contained cyclophosphamide, fludarabine antithymocyte globulin. Methylaminopterin, mycophenolate mofetil...
Abstract The quasielastic neutron scattering index β and the modulus of a protein's quasi-electric dipole moment were utilized to quantitate thermostability wildtype TC230 its mutants. Charged residues Arg314, Glu246, Glu291, some prolines near C-terminus sequence (Pro228, Pro296, Pro308) identified be critical for according these two criteria. By analyzing molecular conformation changes during simulation, it was demonstrated how mutant P228S destabilized by disrupting salt-bridges...
Background and purpose : Coronavirus disease 2019 (COVID-19) was spreading all over the world. Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) primarily invades infects lungs of humans leading to COVID-19. Mild severe clinical symptoms such as fever, cough, shortness breath were existed in those patients. One most common changes these patients abnormal blood routine. However, uncertainty remains regarding dynamic characteristics platelet COVID-19 due limited data. Therefore, we aimed...
Objective Endoscopic variceal sclerotherapy (EVS) is usually carried out at weekly intervals in patients with esophageal bleeding (EVB). However, some receive irregular intervals. In this study we aimed to elucidate the reasons and risk factors for irregular‐interval EVB, evaluate safety efficacy of interrupted these patients. Methods Medical records who were admitted Chinese PLA General Hospital from December 2013 June 2015 EVS retrospectively analyzed. sessions scheduled be repeated...
To investigate the efficacy and safety of haploidentical allo-HSCT in combination reduced intensity preconditioning combined with cyclophosphamid (CTX)-induced immune tolerance after transplanitation for treatment severe aplastic anemia (SAA).A total 15 patients SAA received CTX-induced transplartation General hospital Beijing military command chinese PLA from June 2012 to December 2014. The regimen consisted CTX, fludarabine, busulfex amti-lymphocyte immunoglobin; was induced CTX (50...
Objective To explore efficacy and safety of haploid allogeneic hematopoietic stem cell transplantation (allo-HSCT) for the children with relapsed or refractory acute lymphoblastic leukemia. Methods 20 cases childhood leukemia treated allo-HSCT were collected in Beijing Military General Hospital Hematology from Jan 2010 to 2013, including 12 males 8 females, median age 9 (1-14) years old. There 14 B-ALL 6 T-ALL. When transplation, 10 without remission, after 2 3 times obtain remission....
Objective To observe the effect and toxicity of pegaspargase combined with EPOCH(P-EPOCH)regimen for patients relapse refractory non-Hodgkin's' T-cell lymphoma(T-NHL). Methods A total 15 pathologically diagnosed T-NHL from January 2010 to 2014 Beijing Military Region General Hospital who had been treated CHOP or CHOP-like regimens were refractory. They by P-EPOCH regimen [VP16 50 mg/m2, E-ADM 12 VCR 0.4 dissolved in 500 ml saline sustained static drops 24 h on day 1 4; CTX 750...
Objective To compare the effects of HLA-haploidentical related donors (RD) and unrelated (URD) hematopoietic stem cell transplantations (HSCTs) for leukemia. Methods Ninety-three leukemia patients who underwent allogenic HSCT were divided into two groups including 51 cases RD-HSCT 42 URD-HSCT. In group, a preconditioning regimen with fludarabine (Flu) + busulfan (Bu) cytosine arabinoside (Ara-C) was employed total body irradiation (TBI)+Flu+Ara-C rest 9 cases. URD-HSCT modified Bu+...
To explore the preventative effect of donor peripheral blood stem cell (PBSC) infusion mobilized by granulocyte colony-stimulating factor (G-CSF) for relapsing patients with leukemia after haplotype hematopoietic transplantation (HSCT), as well its therapeutic and safety.G-CSF was given at 5 - 10 µg×kg(-1)×d(-1) to PBSCs were obtained on day frozen allotted storing. PBSC all 20 90 HSCT, second treatment 4 30 first infusion. The occurrence graft-versus-host disease (GVHD), relapse rate high...