A5062840553- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Phytochemical Studies and Bioactivities
- Synthesis and biological activity
- Microbial Metabolism and Applications
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Bioactive Compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phytochemistry and biological activity of medicinal plants
- Redox biology and oxidative stress
- Plant Pathogens and Fungal Diseases
- Antifungal resistance and susceptibility
- Carbohydrate Chemistry and Synthesis
- Phytochemical compounds biological activities
- Epigenetics and DNA Methylation
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Synthesis and Biological Evaluation
- Enzyme Production and Characterization
- Genomics, phytochemicals, and oxidative stress
- Plant biochemistry and biosynthesis
- Ginkgo biloba and Cashew Applications
China Pharmaceutical University
2015-2025
Academy of Military Medical Sciences
2024
Hefei Institutes of Physical Science
2024
Anhui University
2024
Zhejiang University
2024
Huazhong University of Science and Technology
2015-2023
Tongji Hospital
2015-2019
University of Arizona
2016-2017
State Key Laboratory of Natural Medicine
2017
Universitat Autònoma de Barcelona
2017
Each major step leading to the classical yellow, orange and red constituents of <italic>Monascus</italic> azaphilone pigments was defined.
Three pairs of new 8-O-4′-type dinorneolignan enantiomers, (±)-acortatarinowins A–C (1a/1b–3a/3b), a pair (4a/4b) and rare C7–C8′-type (5a/5b) neolignan D E, furofuran-type lignan (±)-acortatarinowin F (6a/6b), along with two known enantiomers (7a/7b 8a/8b), were obtained from the rhizomes Acorus tatarinowii. The separation 1–8 by chiral HPLC using Daicel IC column led to isolation eight 1a/1b–8a/8b, which had variable enantiomeric excess (ee) values approximately 66, 71, 63, 60, 0, 38, 48,...
One new alkaloid, named as acremolin C (1), was isolated from static culture of Antarctic fungus, Aspergillus sydowii SP-1, in an investigation the antimicrobial constituents this microorganism, and its structure determined by spectroscopic methods. Additionally, four known compounds, cyclo-(L-Trp-L-Phe) (2), 4-hydroxyphenylacetic acid (3), (7S)-(+)-hydroxysydonic (4) (7S, 11S)-(+)-12-hydroxysydonic (5), were identified. Biological studies disclosed that compounds 2, 4 5 showed moderate...
To dissect and penetrate complexicity regarding the tissue-specific environment-induced expression modes of cytosolic plastidial terpene biosynthetic genes in A. annua, corresponding mRNAs relevant to biosynthesis were quantitatively compared among distinctive organs during different growth stages. Although all examined gradually elevate from June August tested organs, a putative artemisinin responsible DBR2 mRNA represents most abundant transcript anyplace anytime. Apart others, senescent...
Two disparate polyketide families, the benzenediol lactones and azaphilones, are produced by fungi using iterative synthase (iPKS) enzymes consisting of collaborating partner subunits. Exploitation this common biosynthetic logic iPKS subunit shuffling allowed diversity-oriented combinatorial biosynthesis unprecedented scaffolds new to nature, bearing structural motifs from both these orthogonal natural product families. Starter unit acyltransferase domain replacements proved necessary but...
Two new polyketide compounds, asperulosins A and B ( 1 – 2 ), one prenylated small molecule, asperulosin C 3 along with nine known compounds 4 12 were isolated identified from a fungus Aspergillus rugulosa . Their structures extensively elucidated via HRESIMS, 1D, 2D NMR analysis. The absolute configurations of the determined by comparison their electronic circular dichroism (ECD), calculated ECD spectra, detailed discussion those in previous reports. Structurally, belonged to family...
A series of benzo[a]pyrano[2,3-c]phenazine derivatives with a wide range substitutions at ring C the benzophenazine were designed and synthesized using one-pot, four-component domino reactions. The targeted compounds evaluated for their antitumor activities against HCT116, MCF7, HepG2 A549 cancer cell lines in vitro. most active compound 6{1,2,1,9} featured CN p-dimethylamino phenyl substituents on γ-pyran structure C. Significantly, was found to have highest growth inhibitory activity line...
Abstract High‐performance liquid chromatography with an evaporative light scattering detector and electrospray ionization multistage tandem mass spectrometry (HPLC/ELSD/ESI‐MS n ) was used to identify spirostanol saponins in a saponin extract of Solanum torvum . The fragmentation behavior studied using ESI‐MS 1–3 positive ion mode. MS spectra the [M+H] + ions provide structural information including aglycone type nature sequence sugars. use ELSD allowed profiling nonchromophore‐containing...
In order to utilize and control the invasive weed, bioactive compounds from essential oil of F laveria bidentis ( L .) K untze were studied. Steam distillation extraction one step high‐speed counter‐current chromatography applied separate purify caryophyllene oxide, 7,11‐dimethyl‐3‐methylene‐1,6,10‐dodecatriene, untze. The two‐phase solvent system containing n ‐hexane/acetonitrile/ethanol (5:4:3, v/v/v) was selected for separation mode according partition coefficient values ) target factor...