A5038368213- Drug Transport and Resistance Mechanisms
- Ginseng Biological Effects and Applications
- Berberine and alkaloids research
- Traditional Chinese Medicine Analysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Microbial Natural Products and Biosynthesis
- Cancer, Lipids, and Metabolism
- Amino Acid Enzymes and Metabolism
- Crystallography and molecular interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Photonic and Optical Devices
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmacological Effects of Natural Compounds
- Human Motion and Animation
- Supramolecular Chemistry and Complexes
- Evacuation and Crowd Dynamics
- Microbial Metabolism and Applications
- Wind and Air Flow Studies
- Algebraic and Geometric Analysis
- Ferroptosis and cancer prognosis
- Phytochemistry and biological activities of Ficus species
- Lung Cancer Research Studies
- Caveolin-1 and cellular processes
- Acute Ischemic Stroke Management
Jiangsu University
2025
China Pharmaceutical University
2013-2023
Nanjing Medical University
2018-2023
State Key Laboratory of Natural Medicine
2013-2021
Nanjing Drum Tower Hospital
2016-2021
Central South University
2021
Rutgers, The State University of New Jersey
2016-2020
Wuxi Third People's Hospital
2020
Wuxi Fourth People's Hospital
2020
PLA Rocket Force University of Engineering
2013
Previous studies suggest that the lipid-lowering effect of berberine (BBR) involves actions on low-density lipoprotein receptor and AMP-activated protein kinase signaling pathways. However, implication these mechanisms is unclear because low bioavailability BBR. Because main action site BBR gut intestinal farnesoid X (FXR) plays a pivotal role in regulation lipid metabolism, we hypothesized effects FXR pathway might account for its pharmacological effectiveness. Using wild type (WT)...
Abstract Adriamycin (ADR) induces the over-expression of P-glycoprotein (P-gp) and multiple drug resistance in breast cancer cells. However, biochemical process underlying mechanisms are not clear. Our previous study revealed that ADR increased reactive oxygen species (ROS) generation decreased glutathione (GSH) biosynthesis, while N-acetylcysteine, ROS scavenger, reversed P-gp. The present showed inhibited influx cystine (the source material GSH) activity SLC7A11 transporter (in charge...
Our previous study suggests that berberine (BBR) lowers lipids by modulating bile acids and activating intestinal farnesoid X receptor (FXR). However, to what extent this pathway contributes the hypoglycemic effect of BBR has not been determined. In study, glucose-lowering effects its primary metabolites, berberrubine (M1) demethyleneberberine, in a high-fat diet–induced obese mouse model were studied, their modulation global metabolic profile livers systemic was The results revealed (150...
Abstract Background As a prodrug of 5-fluorouracil (5-FU), orally administrated capecitabine (CAP) undergoes preliminary conversion into active metabolites in the liver and then releases 5-FU gut to exert anti-tumor activity. Since metabolic changes CAP play key role its activation, single kind intestinal or hepatic cell can never be used vitro evaluate pharmacokinetics (PK) pharmacodynamics (PD) nature. Hence, we aimed establish novel system effectively assess PK PD these kinds prodrugs....
Non-alcoholic steatohepatitis (NASH) is emerging as a serious liver disorder characterized by hepatic steatosis and inflammation. Nicotinamide adenine dinucleotide (NAD+) NAD+-dependent deacetylase, SIRT1, play important roles in lipid metabolism non-alcoholic fatty disease (NAFLD). However, their effects on inflammation homeostasis of bile acids (BAs), the extensively proved pathophysiological actors NASH, have not been fully understood. NASH animal model was induced...
A process that combines polymer nanoreplica molding with horizontal dipping was used to fabricate large area ( <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\sim 3\times 5~{\rm inch}^{2}$</tex> </formula> ) distributed feedback laser biosensors (DFBLB) on flexible plastic substrates, which were subsequently incorporated into standard format 96-well microplates. room temperature create subwavelength...
Background. Cholesterol efflux and lipid raft redistribution contribute to attenuating temozolomide resistance of glioblastoma. Ginsenosides are demonstrated modify cholesterol metabolism distribution, the brain distribution central nervous effects whose isoforms Rb1, Rg1, Rg3, CK have been identified. This study aimed reveal role in drug Methods. The ginsenosides on temozolomide-resistant U251 glioblastoma cells were evaluated by content assay, confocal laser, qRT-PCR, Western blot. roles...
Drug resistance of cancer cells is associated with redox homeostasis. The mechanism acquired to antitumor drugs not well understood. Our previous studies revealed that drug and highly expressed P-glycoprotein (P-gp) MCF-7 breast was dependent on intracellular homeostasis declined capacity for scavenging reactive oxygen species (ROS). Recently, we observed that, unlike nontumorigenic MCF-10A, three tumorigenic (MCF-7S, BT474, MDA-MB-231) reprogrammed their metabolism,...
We have demonstrated a tunable external cavity ring laser, in which the lasing wavelength can be controlled by illumination that excites nonlinear dye within photonic crystal resonant reflector.
Staphylococcus aureus, including MRSA strains, poses significant health risks, imposing a disease burden and mortality. We investigate butyrolactone I (BL-1), marine-derived metabolite from Aspergillus terreus, enhancing aminoglycoside efficacy against MRSA. A promising synergy is observed with BL-1 various aminoglycosides, marked by low fractional inhibitory concentration indexes (FICIs < 0.5). Comprehensive studies utilizing USA300 gentamicin reveal remarkable one-fourth reduction in...