A5100665753- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Bone health and osteoporosis research
- Metabolism, Diabetes, and Cancer
- Bone Metabolism and Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Management of metastatic bone disease
- Bone health and treatments
- Pituitary Gland Disorders and Treatments
- NF-κB Signaling Pathways
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Helicobacter pylori-related gastroenterology studies
- Cancer, Lipids, and Metabolism
- Color perception and design
- Pregnancy and preeclampsia studies
- Spine and Intervertebral Disc Pathology
- Diabetic Foot Ulcer Assessment and Management
- Prenatal Screening and Diagnostics
- CAR-T cell therapy research
- Healthcare and Venom Research
- Brain Metastases and Treatment
Hubei University of Chinese Medicine
2025
Guangzhou Medical University
2023-2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Chest Hospital
2025
Zhongshan People's Hospital
2024
Shanghai First People's Hospital
2023-2024
Affiliated Hospital of Southwest Medical University
2020-2024
Shanghai Jiao Tong University
2023-2024
Genesys (United States)
2024
Xiangya Hospital Central South University
2018-2023
This study aims to evaluate the safety and efficacy of BCMA-CD19 compound chimeric antigen receptor T cells (cCAR) dual reset humoral B cell immune system in patients with systemic lupus erythematosus (SLE) nephritis (LN).
DNA N6-methyladenine (N6-mA) demethylase Alkbh1 participates in regulating osteogenic differentiation of mesenchymal stem cell (MSCs) and vascular calcification. However, the role bone metabolism remains unclear.Bone marrow cells (BMSCs)-specific knockout mice were used to investigate metabolism. Western blot, qRT-PCR, immunofluorescent staining evaluate expression or optineurin (optn). Micro-CT, histomorphometric analysis, calcein double-labeling assay phenotypes. Cell qRT-PCR adipogenic...
Abstract Context Primary aldosteronism (PA) is one of the leading causes secondary hypertension, and its diagnostic subtyping consistently presents a clinical challenge. Objective This study aimed to investigate potential 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) in PA classification applicability guiding development treatment plans by increasing sample size. Methods We prospectively enrolled 120 patients with either or nonfunctional adenoma (NFA) for...
Chronic hepatitis B virus (HBV) infection is a serious public health burden, and current therapies cannot achieve satisfactory cure rate. There are high unmet medical needs of novel therapeutic agents with differentiated mechanism action (MOA) from the standard care. RG7834, compound dihydroquinolizinone (DHQ) chemical series, first-in-class highly selective orally bioavailable HBV inhibitor which can reduce both viral antigens DNA action. Here we report discovery RG7834 phenotypic screening...
Abstract Arterial calcification is common, but the mechanisms remain unclear. This study was undertaken to investigate arterial in adiponectin-deficient mice vivo and effects of adiponectin on cultured vascular smooth muscle cells vitro. Alizarin red S staining used detect adiponectin−/− mice. Alkaline phosphatase activity, osteocalcin secretion, Runx2 protein expression were examined calcifying (CVSMCs). The involved signal pathway studied using a mitogen-activated kinase (MAPK) inhibitor...
Abstract Background High glucose could induce structure and function change in cardiomyocytes, PKC plays a core effect the onset progression of diabetic cardiomyopathy, but its underlying downstream signal transduction pathway is still not completely understood. Objectives To study influence high on structure, (Protein Kinase C)/NF-κB(Nuclear factor-κB)/c-fos cultured cardiomyocytes. Methods Using cardiomyocytes neonatal Sprague-Dawley rats as model, groups were divided into: control group...
The clinical characteristics of multidrug-resistant tuberculosis (MDR-TB) patients with concurrent nontuberculous mycobacterial (NTM) infection present significant challenges to treatment. This study investigated the MDR-TB NTM during A retrospective cohort was conducted collect data who initiated treatment between January 2020 and December 2022. total 389 were analyzed, among which 111 lost follow-up 56 missed etiological examination visit period excluded. 222 complete included in this...
The current study aimed to analyze the effects of thyroid diseases on pregnancy outcomes and investigate levothyroxine (L-T4) tablets in treatment hypothyroidism. determined prevalence using two diagnostic criteria, among pregnant women recruited 2010 2014 were initially by 2011 Guidelines American Thyroid Association for Diagnosis Management Disease During Pregnancy Postpartum (2011 ATA Guidelines). Subjects categorized into six groups: Normal, hypothyroxinemia, hypothyroidism, subclinical...
Non-alcoholic steatohepatitis (NASH) is emerging as a serious liver disorder characterized by hepatic steatosis and inflammation. Nicotinamide adenine dinucleotide (NAD+) NAD+-dependent deacetylase, SIRT1, play important roles in lipid metabolism non-alcoholic fatty disease (NAFLD). However, their effects on inflammation homeostasis of bile acids (BAs), the extensively proved pathophysiological actors NASH, have not been fully understood. NASH animal model was induced...
The incidence of thyroid carcinoma (TC) has exhibited a rapid increase in recent years. A proportion TCs exhibit aggressive behavior. present study aimed to investigate the potential role hypoxia‑hypoxia inducible factor 1 subunit α (HIF‑1α)‑periostin axis progression TC. upregulation periostin and HIF‑1α expression levels was detected 95 clinical TC tissues as compared with normal tissues. Hypoxia promoted viability invasion cells this effect inhibited by downregulation periostin. also...
Objective Irritable bowel syndrome (IBS) is a common clinical gastrointestinal dysfunction disorders. 5-sertonon (5-hydroxytryptamine, 5-HT) very important neurotransmitter, which involved in motion and sensation. Solute carrier family 6 member 4 (SLC6A4) gene encode serotonin transporter (SERT) function to rapidly reuptake the most of 5-HT. Therefore, it needed explore association between SLC6A4 polymorphisms IBS. Methods 119 patients 238 healthy controls were administrated detect including...
Objective: To demonstrate the association between pre-pregnancy maternal overweight, obesity and perinatal outcomes of singletons conceived by assisted reproductive technology (ART). Design: Retrospective cohort study from 2006–2015 data a single ART center. Setting: Assisted Reproduction Center, Northwest Women's Children's Hospital, Xi'an, Northwestern China. Patients: We included 7,818 women undergoing their singleton infants. Interventions: None. Main Outcome Measure: The primary outcome...
Atrialfibrillation (AF) is associated with the activation of renin-angiotensin-aldosterone system in atria. It not clear whether expression a mineralocorticoid receptor (MR), or 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2), conferring aldosterone specificity to MR, patients AF altered.
Objective: Thromboangiitis obliterans (TAO) is a segmental nonatherosclerotic inflammatory vascular disease characterized by recurrent progressive reactions and thrombosis in the small medium-sized arteries veins of extremities. However, there are few bibliometric studies on TAO. Therefore, this study was employed to generalize research status, hotspots development trends TAO-related research. Methods: The data from 1999 2022 were collected Web Science core collection database, analyzed...