A5083076836- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Sesquiterpenes and Asteraceae Studies
- Analytical Chemistry and Chromatography
- Plant-Derived Bioactive Compounds
- Natural Antidiabetic Agents Studies
- Bioactive Natural Diterpenoids Research
- Ionic liquids properties and applications
- Traditional Chinese Medicine Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Phytochemicals and Antioxidant Activities
- Allelopathy and phytotoxic interactions
- Electrochemical Analysis and Applications
- Essential Oils and Antimicrobial Activity
- Chromatography in Natural Products
- Pomegranate: compositions and health benefits
- Ubiquitin and proteasome pathways
- Traditional and Medicinal Uses of Annonaceae
- Cancer-related Molecular Pathways
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- Tannin, Tannase and Anticancer Activities
- Analytical Methods in Pharmaceuticals
- Analytical chemistry methods development
- Chemical synthesis and alkaloids
Xinjiang Technical Institute of Physics & Chemistry
2009-2025
University of Chinese Academy of Sciences
2010-2025
Chinese Academy of Sciences
2009-2024
Shanghai Tenth People's Hospital
2024
Tongji University
2024
University of Rhode Island
2016-2023
Nanjing Normal University
2023
Nanchang Hangkong University
2021
Lanzhou University
2020
First Hospital of Lanzhou University
2020
Kaliziri extract (KZE) is a traditional Uyghur medicine (TUM), used by hospitals in China as an injection for treatment of vitiligo more than 30 years. Clinical application has shown that this obvious therapeutic effects. However, its phytochemical analysis and mechanism have not been examined. KZE was extracted from seeds [Vernonia anthelmintica (L.) Willd.] ethanol-water (80:20, v/v), components were identified LC-MS/MS, the signaling pathway melanin synthesis treated murine B16 melanoma...
Chronic hepatitis B virus (HBV) infection is a serious public health burden, and current therapies cannot achieve satisfactory cure rate. There are high unmet medical needs of novel therapeutic agents with differentiated mechanism action (MOA) from the standard care. RG7834, compound dihydroquinolizinone (DHQ) chemical series, first-in-class highly selective orally bioavailable HBV inhibitor which can reduce both viral antigens DNA action. Here we report discovery RG7834 phenotypic screening...
Oxidative stress and free radical generation accelerate the formation of advanced glycation endproducts (AGEs) which are linked to several chronic diseases. Published data suggest that phenolic-rich plant foods, show promise as natural anti-AGEs agents due their anti-oxidation capacities. A phenolic-enriched maple syrup extract (MSX) has previously been reported anti-inflammatory neuroprotective effects but its anti-AGE remain unknown. Therefore, herein, we investigated anti-glycation MSX...
Abstract Pomegranate ( Punica granatum L.) fruit and flower extracts, which are rich sources of bioactive phenolics, widely utilized as ingredients in botanical dietary supplements. While the phenolic characterization extracts pomegranate has been previously studied by liquid chromatography with tandem mass spectrometry, there is lack similar data for flowers. Herein, time‐of‐flight spectrometry was to comprehensively characterize phenolics present two their vitro vivo biological effects,...
The S phase kinase-associated protein 1 (Skp1), an adaptor of the Skp1-Cul1-F-box complex, binds ubiquitin E3 ligase Skp2 and is critical to its biological functions. Targeting Skp1 by a small compound 6-O-angeloylplenolin (6-OAP) results in dissociation degradation mitotic arrest lung cancer cells. Here, using proteome microarray containing 16,368 proteins biotinylated 6-OAP, we identified 99 that could bind with STAT3 sitting at central position 6-OAP interactome. formed hydrogen bonds...
ABSTRACT In the present study, it was demonstrated that ethyl acetate soluble fraction partitioned from heartwood of Dalbergia odorifera T. Chen (HEF) had a remarkable inhibitory effect on α ‐glucosidase. Therefore HEF selected as starting material for screening potential ‐glucosidase inhibitors using ultrafiltration liquid chromatography/mass spectrometry (UF‐LC/MS). Twenty‐six compounds were identified with analysis LC/MS. UF assay indicated 18 compositions might be in HEF; eight them...
Maple sap, collected from the sugar maple (Acer saccharum) tree, is boiled to produce popular plant-derived sweetener, syrup, which can then be further evaporated yield a traditional North American confectionery, sugar. Although sap and syrup have been previously studied, phytochemical constituents of are unknown. Herein, 30 phenolic compounds, 1–30, primarily lignans, were isolated identified (by HRESIMS NMR) The isolates included phenylpropanoid-based lignan tetramers...
The damage that combined heavy metals cause to plants is a global environmental problem, and it also harder detect compared with from solitary metal. One mechanism, metal-induced cellular oxidative damage, occurs during the early stage of stress. For monitoring plant metals, in-situ detection in soybean leaf cells was performed under lanthanum (La, an emerging metal pollutant) lead (Pb, conventional stress, using vitronectin-like protein (VN, Lewis base binds ions) as biomarker. A living...
A convenient and versatile method was developed for the separation detection of alkaline earth metal ions by ion chromatography with indirect UV detection. The chromatographic Mg 2+ , Ca Sr performed on a carboxylic acid base cation exchange column using imidazolium ionic liquid/acid as mobile phase, in which liquid acted an UV‐absorption reagent. effects liquids, wavelength, acids temperature retention were investigated. main factors influencing background absorption reagent concentration...
Tanshinone IIA (TIIA), a phenanthrenequinone derivative extracted from Salvia miltiorrhiza BUNGE, has been reported to be natural anti-cancer agent in variety of tumor cells. However, the effect TIIA on gastric cancer cells remains unknown. In present study, we investigated influence malignant phenotype SGC7901 cells.Cells cultured vitro were treated with (0, 1, 5, 10 μg/ml) and after incubation for different periods, cell proliferation was measured by MTT method apoptosis cycling assessed...
The phenolic contents of plant foods are commonly quantified by the Folin–Ciocalteu assay based on gallic acid equivalents (GAEs). However, this may lead to inaccuracies because is not always representative structural heterogeneity phenolics. Therefore, product-specific standards have been developed for quantification several foods. Currently, maple-derived (syrup, sugar, sap/water, and extracts) GAEs. Because lignans predominant phenolics present in maple, herein, a maple lignan-enriched...
Dexmedetomidine, used as an adjuvant to local anesthetics (LAs), may prolong the duration of peripheral nerve block. However, effect dexmedetomidine on neurotoxicity LAs is not completely understood. The present study was designed investigate efficacy two doses ropivacaine and its protective against LAs. Paw withdrawal thermal latency testing detect sensory blockade. Extensor postural thrust motor results demonstrated that addition prolonged blockade in a dose‑dependent manner compared with...
Indirect ultraviolet detection was conducted in ultraviolet‐absorption‐agent‐added mobile phase to complete the of absence absorption functional group analytes. Compared with precolumn derivatization or postcolumn derivatization, this method can be widely used, has advantages simple operation and good linear relationship. Chromatographic separation Li + , Na K NH 4 performed on a carboxylic acid base cation exchange column using imidazolium ionic liquid/acid/organic solvent as phase, which...
Abstract Five new nonalkaloid constituents, a neolignan, japonin A ( 1 ), macrocyclic lactone, B 2 (phenylethyl)benzoquinone, C 3 phenanthraquinone, D 4 as well dihydrostilbene, stilbostemin M 5 were isolated from the roots of Stemona japonica , together with eight known compounds. Their structures established by spectroscopic analyses.
A simple and effective method employing LC-ESI-QTOF-MS was established for the qualitative analysis of chemical constituents in<italic>Neopicrorhiza scrphulariiflora</italic>roots.