A5053934047- Alkaloids: synthesis and pharmacology
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and Biological Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Bioactivity Studies
- Insect Pest Control Strategies
- Chemical synthesis and alkaloids
- Sesquiterpenes and Asteraceae Studies
- Plant and Fungal Species Descriptions
- Essential Oils and Antimicrobial Activity
- Natural Compound Pharmacology Studies
- Synthesis of Organic Compounds
- Pharmacological Effects of Natural Compounds
- Phytochemical Studies and Bioactivities
- Berberine and alkaloids research
- Bioactive Compounds and Antitumor Agents
- Bone Metabolism and Diseases
- Marine Sponges and Natural Products
- Phytochemistry and Bioactive Compounds
- Plant-derived Lignans Synthesis and Bioactivity
- NF-κB Signaling Pathways
- Plant biochemistry and biosynthesis
- Synthesis and bioactivity of alkaloids
Ebara (Japan)
2016-2025
Hoshi University
2016-2025
University of Malaya
2009-2011
Tokushima Bunri University
2010
National Institute of Health Sciences
2009
Two novel indole alkaloids, alsmaphorazines A and B, were isolated from the leaves of Alstonia pneumatophora (Apocynaceae), their structures determined on basis 2D NMR MS spectral analysis. These alkaloids possessed a new skeleton consisting an 1,2-oxazinane isoxazolidine chromophore. The absolute configuration alsmaphorazine B was by using CD Alsmaphorazine inhibited NO production in LPS-stimulated J774.1 cells dose-dependently without affecting cell viability.
Two new bisindole alkaloids, bisnicalaterines B and C (1 2) consisting of an eburnane a corynanthe type skeletons, were isolated from the bark Hunteria zeylanica. Their absolute structures determined by combination NMR, CD, computational methods, each them was shown to be in atropisomeric relationship. Bisnicalaterines showed potent vasorelaxant activity on rat aorta.
Five new limonoids, ceramicines E—I (1—5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry them were fully elucidated based on 1D- 2D-NMR data. Ceramicines (1—5) exhibited moderate cell growth inhibitory activities a range lines (HL-60, A549, MCF7, HCT116). absolute structure previously ceramicine B (6) was also by circular dichroism (CD) X-ray analysis.
Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration 1 were elucidated on basis 2D NMR correlations simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity decreased protein expression dose-dependently.
A new bisindole alkaloid, bisnicalaterine (1), consisting of two vobasine-type skeletons, and 3-epivobasinol (2) 3-O-methylepivobasinol (3), with were isolated from the leaves Hunteria zeylanica, their structures elucidated on basis spectroscopic data chemical correlation. Bisnicalaterine showed moderate cytotoxicity against various human cancer cell lines.
Eight new guaipyridine sesquiterpene alkaloids, rupestines F—M (1—8) were isolated from the leaves of Artemisia rupestris and their structures elucidated on basis 2D-NMR data. The absolute configurations 1—8 have been assigned by comparison experimental calculated circular dichroism (CD) spectra.
Three new limonoids, chisomicines A−C (1−3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory activity in J774.1 cells stimulated LPS dose-dependently at high cell viability.
Three new bisindole alkaloids, bisleuconothines B–D (1–3), were isolated from the bark of Leuconotis griffithii. Their structures elucidated by 1D and 2D NMR spectroscopy DFT calculations. Bisleuconothine B (1) is first monoterpene indole alkaloid dimer featuring bridges between both C-16–C-10′ C-2–O–C-9′. All compounds deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.
We have previously reported that bisleuconothine A (Bis-A), a novel bisindole alkaloid isolated from Leuconotis griffithii, showed cytostatic activity in several cell lines. In this report, the mechanism of Bis-A-induced was investigated detail using A549 cells. Bis-A did not cause apoptosis, as indicated by analysis annexin V and propidium iodide staining. Expression all tested apoptosis-related proteins also unaffected treatment. found to increase LC3 lipidation MCF7 cells well cells,...