A5019835475- Plant-Derived Bioactive Compounds
- Natural Antidiabetic Agents Studies
- Pomegranate: compositions and health benefits
- Phytochemicals and Antioxidant Activities
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Tea Polyphenols and Effects
- Tannin, Tannase and Anticancer Activities
- Sesame and Sesamin Research
- Immune Response and Inflammation
- Phytochemistry and Bioactive Compounds
- Histone Deacetylase Inhibitors Research
- Chemokine receptors and signaling
- Phytochemistry and Biological Activities
- Multiple Myeloma Research and Treatments
- Hops Chemistry and Applications
- Vitamin D Research Studies
- Effects and risks of endocrine disrupting chemicals
- Nuclear Receptors and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Trace Elements in Health
- Microbial Natural Products and Biosynthesis
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Phytoestrogen effects and research
Brown University
2024-2025
University of Rhode Island
2013-2021
Glycation is associated with several neurodegenerative disorders, including Alzheimer’s disease (AD), where it potentiates the aggregation and toxicity of proteins such as β-amyloid (Aβ). Published studies support anti-glycation neuroprotective effects polyphenol-rich fruits, berries, which are rich in anthocyanins. Herein, blackberry, black raspberry, blueberry, cranberry, red strawberry extracts were evaluated for: (1) total phenolic anthocyanins contents, (2) free radical (DPPH)...
Increasing evidence supports the beneficial effects of polyphenol-rich diets, including traditional Mediterranean diet, for management cardiovascular disease, obesity and neurodegenerative diseases. However, a common concern when discussing protective diets against diseases is whether these compounds are present in systemic circulation their intact/parent forms order to exert vivo. Here, we explore two classes dietary polyphenols, namely isoflavones lignans, gut microbial-derived metabolites...
Objectives: Urolithins, ellagitannin-gut microbial-derived metabolites, have been reported to mediate pomegranate's neuroprotective effects against Alzheimer's disease (AD), but there are limited data on their neuroinflammation. Herein, we: (1) evaluated whether urolithins (urolithins A and B methylated derivatives) attenuate neuroinflammation in murine BV-2 microglia human SH-SY5Y neurons, (2) hippocampus of transgenic AD (R1.40) mice administered a pomegranate extract (PE; 100 or 200...
Mucuna pruriens (Mucuna) has been prescribed in Ayurveda for various brain ailments including 'kampavata' (tremors) or Parkinson's disease (PD). While is a well-known natural source of levodopa (L-dopa), published studies suggest that other bioactive compounds may also be responsible its anti-PD effects. To investigate this hypothesis, an L-dopa reduced (<0.1%) M. seeds extract (MPE) was prepared and evaluated effects cellular (murine BV-2 microglia human SH-SY5Y neuroblastoma cells),...
Abstract Cerebral amyloid angiopathy (CAA) is a prevalent vascular dementia and common comorbidity of Alzheimer’s disease (AD). While it known that fibrillar β (Aβ) deposits leads to deterioration can drive parenchymal CAA related inflammation (CAA-ri), underlying mechanisms pathology remain poorly understood. Here, we conducted brain regional proteomic analysis early late stages in the rTg-DI rat model gain molecular insight CAA/CAA-ri progression identify potential protein markers...
Oxidative stress and free radical generation accelerate the formation of advanced glycation endproducts (AGEs) which are linked to several chronic diseases. Published data suggest that phenolic-rich plant foods, show promise as natural anti-AGEs agents due their anti-oxidation capacities. A phenolic-enriched maple syrup extract (MSX) has previously been reported anti-inflammatory neuroprotective effects but its anti-AGE remain unknown. Therefore, herein, we investigated anti-glycation MSX...
Black cumin (Nigella sativa) seed extract has been shown to improve dermatological conditions, yet its beneficial effects for skin are not fully elucidated. Herein, Thymocid®, a chemically standardized black extract, was investigated cosmeceutical potential including anti-aging properties associated with modulation of glycation, collagen cross-linking, and collagenase elastase activities, as well antimelanogenic effect in murine melanoma B16F10 cells. Thymocid® (50, 100, 300 µg/mL) inhibited...
High grade serous ovarian cancer (HGSOC) is the most lethal of all gynecologic malignancies in which majority patients eventually develop chemoresistant recurrent disease. Ubiquitin C-terminal hydrolase L1 (UCHL1) a deubiquitinating enzyme canonically known for its involvement neurodegeneration, but recently has been shown to play key role tumorigenesis. Furthermore, UCHL1 garnered attention across multitude subtypes as it ability be targeted through small molecule inhibition. Therefore,...
Maple sap, collected from the sugar maple (Acer saccharum) tree, is boiled to produce popular plant-derived sweetener, syrup, which can then be further evaporated yield a traditional North American confectionery, sugar. Although sap and syrup have been previously studied, phytochemical constituents of are unknown. Herein, 30 phenolic compounds, 1–30, primarily lignans, were isolated identified (by HRESIMS NMR) The isolates included phenylpropanoid-based lignan tetramers...
Objectives: Alzheimer's disease (AD) is a growing global health crisis exacerbated by increasing life span and an aging demographic. Convergent lines of evidence, including genome-wide association studies, strongly implicate neuroinflammation in the pathogenesis AD. Several dietary agents, phenolic-rich foods, show promise for prevention and/or management AD, which large part, has been attributed to their anti-inflammatory effects. We previously reported that food-grade phenolic-enriched...
Diets rich in fats are linked to elevated systemic inflammation, which augments the progression of inflammatory-related disorders including non-alcoholic fatty liver disease (NAFLD) and neurodegenerative diseases. A phenolic-enriched pomegranate fruit extract (PE) was investigated for its hepatoprotective anti-inflammatory effects male C57BL/6 mice fed either a high-fat diet or standard rodent with without 1% PE 12 weeks. Mouse livers hippocampi were evaluated expression genes associated...
Glucitol-core containing gallotannins (GCGs) from the red maple (Acer rubrum) species have been reported to exhibit skin beneficial activities but their inhibitory effects on elastase remain unclear. Herein, we evaluated a series of GCGs for anti-elastase activity, permeability, and cytoprotective in human keratinocytes HaCaT cells. GCGs' were enhanced as number galloyl groups increased, which may be attributed formation more stable protein–ligand complexes. In addition, predicted moderate...
Rhizoleucinoside (1), a unique rhamnolipid–amino alcohol hybrid, was isolated from the rhizobial symbiont bacterium Bradyrhizobium sp. BTAi1. Compound 1 features rare rhamnolipid core attached to an unprecedented leucinol moiety. Its structure and absolute configuration were determined by spectroscopic analysis, tandem mass spectrometry, chemical degradation, application of Marfey's method. possesses moderate cytotoxicity BV-2 murine microglia highly aggressive proliferating immortalized...
Abstract Myeloid-derived suppressor cells (MDSCs) promote immunosuppressive activities in the tumor microenvironment (TME), resulting increased burden and diminishing anti-tumor response of immunotherapies. While primary metastatic tumors are typically focal points therapeutic development, immune TME differentially programmed by tissue site. In particular, MDSCs uniquely within different organs context progression. Given that MDSC plasticity is shaped surrounding environment, proteomes from...
In the course of our group's investigation members maple (Acer) genus, a series glucitol-core containing gallotannins (GCGs) were-isolated and identified (by NMR HREISMS). Among higher plants, only certain species are known to produce GCGs, compounds with potential nutraceutical cosmetic applications due their reported antioxidant, antidiabetic, anti-α-glucosidase, anti-glycation, anticancer, skin. health promoting effects. Herein, we sought investigate whether previously un-investigated...
Abstract Iron is an essential nutrient but toxic in excess. deficiency the most prevalent nutritional and typically linked to inadequate intake. excess also common usually due genetic defects that perturb expression of hepcidin, a hormone inhibits dietary iron absorption. Our understanding absorption far exceeds excretion, which believed contribute minimally homeostasis. Prior discovery multiple studies showed undergoes biliary excretion. We recently reported wild-type mice raised on...
Mucuna ( pruriens ; commonly known as velvet bean) is a medicinal plant that has been traditionally used in Ayurvedic medicine for various conditions including diabetes, inflammation, and brain dysfunctions. It contains levodopa (L‐DOPA) the treatment Parkinson's disease (PD). Although anti‐PD effects of have associated with its L‐DOPA content, recent studies suggest other bioactive compounds may also contribute to protective against PD. Herein, we initiated this study develop evaluate...