A5053419838- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Antimicrobial Resistance in Staphylococcus
- Drug Transport and Resistance Mechanisms
- Natural Antidiabetic Agents Studies
- Antimicrobial Peptides and Activities
- Bacillus and Francisella bacterial research
- Antioxidant Activity and Oxidative Stress
- Pomegranate: compositions and health benefits
- Sesame and Sesamin Research
- Antibiotic Resistance in Bacteria
- Biochemical effects in animals
- Advanced biosensing and bioanalysis techniques
- Phytochemicals and Antioxidant Activities
- Advanced Nanomaterials in Catalysis
- Bacteriophages and microbial interactions
Salve Regina University
2016-2023
Glycation is associated with several neurodegenerative disorders, including Alzheimer’s disease (AD), where it potentiates the aggregation and toxicity of proteins such as β-amyloid (Aβ). Published studies support anti-glycation neuroprotective effects polyphenol-rich fruits, berries, which are rich in anthocyanins. Herein, blackberry, black raspberry, blueberry, cranberry, red strawberry extracts were evaluated for: (1) total phenolic anthocyanins contents, (2) free radical (DPPH)...
Objectives: Urolithins, ellagitannin-gut microbial-derived metabolites, have been reported to mediate pomegranate's neuroprotective effects against Alzheimer's disease (AD), but there are limited data on their neuroinflammation. Herein, we: (1) evaluated whether urolithins (urolithins A and B methylated derivatives) attenuate neuroinflammation in murine BV-2 microglia human SH-SY5Y neurons, (2) hippocampus of transgenic AD (R1.40) mice administered a pomegranate extract (PE; 100 or 200...
Traditional therapeutics to treat bacterial infections have given rise multi-drug resistant pathogens, which pose a major threat human and animal health. In several quorum sensing (QS)-a cell-cell communication system in bacteria-controls the expression of genes responsible for pathogenesis, thus representing novel target fight against infections. Based on structure autoinducers QS activity other inhibitors, we hypothesize that β-keto esters with aryl functionality could possess anti-QS...
Quorum sensing (QS) antagonists have been proposed as novel therapeutic agents to combat bacterial infections. We previously reported that the secondary metabolite 3-methyl-N-(2'-phenylethyl)-butyramide, produced by a marine bacterium identified Halobacillussalinus, inhibits QS controlled phenotypes in multiple Gram-negative reporter strains. Here we report N-phenethyl hexanamide, structurally-related compound Vibrioneptunius, similarly demonstrates inhibitory properties. To more fully...
Antimicrobial compounds can combat microbes through modulating host immune defense, inhibiting bacteria survival and growth, or impeding virulence factors. In the present study, a panel of substituted diphenyl amide previously found to disrupt bacterial quorum sensing were investigated several promote in Galleria mellonella model when provided therapeutically treat Gram-positive infection from methicillin-resistant Staphylococcus aureus strain MW2. Out 21 tested compounds, N...