A5046562168- Immune cells in cancer
- CAR-T cell therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Neurogenetic and Muscular Disorders Research
- Chronic Lymphocytic Leukemia Research
- Virus-based gene therapy research
- Amyotrophic Lateral Sclerosis Research
- Acute Lymphoblastic Leukemia research
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Kruppel-like factors research
- Neuroblastoma Research and Treatments
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Brain Metastases and Treatment
- 3D Printing in Biomedical Research
- Chronic Myeloid Leukemia Treatments
- Nicotinic Acetylcholine Receptors Study
Brown University
2021-2023
Allen Institute for Brain Science
2023
Roger Williams Medical Center
2018-2021
Providence College
2021
Spinal motor neurons have been implicated in the loss of function that occurs with advancing age. However, cellular and molecular mechanisms impair these during aging remain unknown. Here, we show do not die old female male mice, rhesus monkeys, humans. Instead, selectively progressively shed excitatory synaptic inputs throughout soma dendritic arbor aging. Thus, aged contain a circuitry reduced ratio to inhibitory synapses may be responsible for diminished ability activate commence...
Lynx1 is a glycosylphosphatidylinositol (GPI)-linked protein shown to affect synaptic plasticity through modulation of nicotinic acetylcholine receptor (nAChR) subtypes in the brain. Because this function and structural similarity α-bungarotoxin, which binds muscle-specific nAChRs with high affinity, promising candidate for modulating skeletal muscles. However, little known about expression roles muscles neuromuscular junctions (NMJs). Here, we show that expressed muscles, increases during...
Abstract Introduction Checkpoint inhibitors (CI) have greatly impacted the treatment of solid tumors. Success in liver has been more limited. When intravenously infused, CI is delivered predominantly to extrahepatic sites, which results systemic side effects. Previously, we reported on regional delivery cellular immunotherapy for tumors using pressure-enabled drug (PEDD™, TriSalus™ Life Sciences, Inc.). We hypothesized that PEDD would improve therapeutic index (TI). Methods In a murine model...
Microglia have been found to acquire unique region-dependent deleterious features with age and diseases that contribute neuronal dysfunction degeneration in the brain. However, it remains unknown whether microglia exhibit similar phenotypic heterogeneity spinal cord. Here, we performed a regional analysis of cord 3-, 16-, 23-, 30-month-old mice. Using light electron microscopy, discovered an increasingly activated phenotype during course aging regardless location. causes ventral but not...
Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), only limited success. We hypothesize that regional delivery (RD) CPIs can improve activity in and minimize systemic exposure, thereby reducing immune-related adverse events (irAE). Using a murine model colorectal cancer metastases (LM), we confirmed high levels PD-L1 expression on tumor cells myeloid-derived suppressor (L-MDSC). In vivo, detected improved LM response at 3 mg/kg PTD7 via portal...
Amyotrophic Lateral Sclerosis (ALS) is a currently incurable disease that causes progressive motor neuron loss, paralysis and death. Skeletal muscle pathology occurs early during the course of ALS. It characterized by impaired mitochondrial biogenesis, metabolic dysfunction deterioration neuromuscular junction (NMJ), synapse through which neurons communicate with muscles. Therefore, better understanding molecules underlie this may lead to therapies slow loss delay ALS progression. Kruppel...
Abstract Introduction We have demonstrated safety and clinical activity with anti-CEA CAR-T (Sorrento/TNK Therapeutics, Inc.) regional infusions for treatment of liver metastases (LM) using a pressure-enabled drug delivery device (PEDD™, TriSalus™ Life Sciences, to increase penetration. To further explore the potential benefit PEDD, we developed pre-clinical murine LM model that enables correlation infusion pressure response. Methodology Mice CEA+ were infused into portal vein specified rate...
Abstract Liver is a tolerogenic organ and has variety of immune cells resulting in profoundly immunosuppressive space. We recently reported that GM-CSF/JAK2/STAT3 axis drives liver myeloid suppressor cell (L-MDSC) proliferation STAT3 inhibition causes activation apoptosis signaling via Bax up-regulation. Herein, we explore specific programming events promote L-MDSC suppressive conditioning. Bone marrow derived MDSC (BM-MDSC) were expanded CD45.1+ mice response to intraperitoneal MC38 tumors....
Background: In the last few years, several clinical discontinuation trials have demonstrated that 40–60% of chronic phase CML patients (CP‐CML) who achieved a stable deep molecular response, can stop therapy without relapsing. However, there is no consensus as to whether or not depth response prognostic factor for treatment‐free remission (TFR), which reflected in discrepancy between various guidelines and opinions experts field regarding optimal required, MR 4.0 4.5 , TFR attempt. Aims:...