A5101756275- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Effects of Radiation Exposure
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Lung Cancer Treatments and Mutations
- Complement system in diseases
- MicroRNA in disease regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Sarcoma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Extracellular vesicles in disease
- Advanced Proteomics Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Retinoids in leukemia and cellular processes
- Carcinogens and Genotoxicity Assessment
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
Guangzhou Medical University
2023-2024
Third Affiliated Hospital of Guangzhou Medical University
2023
Huizhou University
2023
Jilin University
2013-2022
First Hospital of Jilin University
2013-2022
VA Palo Alto Health Care System
2020
Stanford University
2020
First Bethune Hospital of Jilin University
2014-2015
The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor, especially for patients with adverse prognostic factors. In this phase II clinical trial, we evaluated the efficacy and safety intrathecal chemotherapy (IC) combined concomitant involved‐field radiotherapy (IF‐RT) treating LM Fifty‐nine various were enrolled between May 2010 December 2014. Concurrent therapy consisted IC (methotrexate 12.5–15 mg dexamethasone 5 mg, weekly) IF‐RT (whole brain and/or spinal...
Recent evidence indicates that limited availability and cytotoxicity have restricted the development of natural killer (NK) cells in adoptive cellular immunotherapy (ACI). While it has been reported low-dose ionizing radiation (LDIR) could enhance immune response animal studies, influence LDIR at level less well defined. In this study, authors aim to investigate direct effects on NK potential mechanism, explore application activation expansion by ACI. The found were markedly augmented LDIR....
In this study, we examined the characteristics and aimed to increase knowledge of clinical features leptomeningeal metastasis (LM). The data, including initial diagnosis treatment primary tumor, manifestations, neuroimaging findings, cerebrospinal fluid (CSF) examination, were analyzed. For patients with adenocarcinoma/breast cancer, incidence cranial lesions nerve paralysis was obviously higher than small cell lung cancer. Whereas, involvement intravertebral canal lower that Patients cancer...
Objectives: We aim to determine the feasibility, safety, maximally tolerated dose (MTD), recommended and potential anti-tumor activity of intrathecal pemetrexed (IP). Materials Methods: Lung adenocarcinoma patients with recurrent or progressive leptomeningeal metastases (LM) after chemotherapy were recruited. IP was escalated from 10 mg. A minimum three a maximum six enrolled in each cohort. Schedule protocol twice per week for 2 weeks induction therapy, followed by once 4 consolidation...
Abstract Although low‐dose radiation ( LDR ) possesses the two distinct functions of inducing hormesis and adaptive responses, which result in immune enhancement tumor inhibition, its clinical applications have not yet been elucidated. The major obstacle that hinders application setting is mechanisms underlying induction inhibition are unclear, risks associated with still unknown. Thus, to overcome this elucidate mediating antitumor effects , study, we established an vivo lung cancer model...
A phase I/II study of intrathecal pemetrexed (IP) combined with involved-field radiotherapy (IFRT) was performed to determine feasibility, safety, and antitumor activity for leptomeningeal metastases (LM) from solid tumors.Participants first received induction IP administration, followed by concomitant within 3 days. The regimen consisted (pemetrexed 10 mg, dexamethasone 5 once per week, 4 times in weeks) IFRT (40 Gy 20 fractions). Six participants were recruited assess feasibility I, then...
Low-dose radiation (LDR) induces hormesis and adaptive response in normal cells but not cancer cells, suggesting its potential protection of tissue against damage induced by conventional radiotherapy. However, the underlying mechanisms are well established. We addressed this present study examining role ataxia telangiectasia mutated (ATM) signaling pathway to LDR using A549 human lung adenocarcinoma HBE135-E6E7 (HBE) epithelial cells. found that LDR-activated ATM was initiating event HBE...
Abstract Therapeutic conditions for acute leukemia (AL) mainly rely on diagnosis and detection of minimal residual disease (MRD). However, no serum biomarker has been available clinicians to make AL assessment MRD. In this study, we performed bead fractionation/MALDI‐TOF‐MS analysis sera from patients with AL. Support vector machine algorithm was used obtain diagnostic model that discriminated proteomic spectra controls. Twenty‐six features p <0.00001 had optimal discriminatory...
Background: Leptomeningeal metastasis (LM) has frequently been observed in patients with lung adenocarcinoma. So far, its diagnosis and disease course monitoring are still extremely difficult. Moreover, there is no effective treatment regimen for LM due to a lack knowledge on the molecular mechanism of LM. This study aimed identify LM-related cerebrospinal fluid (CSF) miRNAs, which have potential value diagnosing exploring mechanism. Methods: CSF miRNAs were screened verified by microarray...
The present study was designed to determine whether the Thinprep plus Papanicolaou stain (Thinprep) method is more sensitive than Cytospin-coupled Wright-Giemsa (WG) (Cytospin) in diagnosis of leptomeningeal metastasis (LM) from malignant solid tumors cerebrospinal fluid (CSF). We also explored if could be used differential type primary tumor cells based on morphology CSF samples.The morphological features fresh samples were analyzed using both methods. cell detection rates compared between...
Low-dose ionizing radiation (LDIR) induces hormesis, exerts an adoptive effect on normal mammalian cells and stimulates cell proliferation; however, this is absent in cancer cells. Little known the molecular mechanisms underlying differential response between In present study, it was demonstrated that human prostate line PC-3 RWPE-1 exhibited biological responses to LDIR. Through cycle analyses, LDIR inhibited growth arrested at S G2/M phases cells, but not Using western blotting, 75 mGy...
MicroRNAs (miRs), which regulate target gene expression at the post-transcriptional level, play a crucial role in inducing biological effects upon high-dose ionizing radiation. Yet, miR profiles response to repeated low-dose radiation (LDR) vivo have not been elucidated. This study investigated of 11 miRs with functions involved metabolism, DNA damage and repair, inflammation, fibrosis mouse liver, heart, testis LDR exposure for 4 months. The were evaluated using stem-loop quantitative...
Leptomeningeal metastasis, which results from metastasis of tumors to the arachnoid and pia mater, can lead dissemination tumor cells throughout subarachnoid space via cerebral spinal fluid, frequently with a poor prognosis. The primary in adults is most often breast cancer, lung or melanoma. Although leptomeningeal due cholangiocarcinoma has been reported, best our knowledge there no cytologically confirmed report hepatocellular carcinoma. We herein case carcinoma 53-year-old woman...
Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and malignant form of lung cancer with poor prognosis for patients. The common sites metastases are the liver, adrenal glands, bone brain. LCNEC rarely metastasizes to small intestine, ovaries, tonsils, mandible, vulva or spine. To best our knowledge, there have been no reports leptomeningeal metastasis date. present case report describes an unusual from pulmonary alongside review literature. Biopsies lesions cervical lymph...
The present study reports the case of a 53-year-old man with leptomeningeal metastasis from early glottic laryngeal cancer. patient had been diagnosed squamous cell carcinoma larynx 9 years previously. current symptoms included recurring headache that persisted for 1 month and vomiting week. A magnetic resonance imaging scan head revealed multiple enhancing lesions in brain line-like enhancements fold. Computed tomography scans head, neck, chest abdomen showed no nodular lesions. Cytological...
Objective: To investigate the feasibility, safety and efficacy of intrathecal pemetrexed (IP) treated for patients with leptomeningeal metastases (LM) from solid tumors. Methods: Forty-seven receiving chemotherapy in First Hospital Jilin University 2017 to 2018 were selected. The study adopted classical dose-climbing model included 13 meningeal metastasis non-small cell lung cancer who had relapsed refractory after multiple previous treatments including chemotherapy. Based on dose climbing...