A5100617012- Ovarian function and disorders
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Assisted Reproductive Technology and Twin Pregnancy
- Gynecological conditions and treatments
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Reproductive System and Pregnancy
- Gut microbiota and health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Signaling Pathways in Disease
- Endometriosis Research and Treatment
- Brain Metastases and Treatment
- Reproductive tract infections research
- Cardiac Imaging and Diagnostics
- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Inflammasome and immune disorders
- Nerve injury and regeneration
- Tracheal and airway disorders
Sun Yat-sen Memorial Hospital
2014-2024
Sun Yat-sen University
2014-2024
Southwest Hospital
2024
Capital Medical University
2012-2024
Army Medical University
2008-2024
Tianjin University of Traditional Chinese Medicine
2024
Peking University
2012-2023
Ministry of Education of the People's Republic of China
2023
Peking University Third Hospital
2023
Aichi Cancer Center
2023
Aims: To evaluate HAb18G/CD147 as a cancer‐associated biomarker using its monoclonal antibody HAb18. Methods and results: On immunohistochemical analysis of 28 tissue microarrays pathological sections 1117 breast samples, was expressed in carcinoma with an overall positivity rate 67.76%, which significantly higher than that sarcomas (27.34%, P < 0.0001) normal epithelial (5.18%, fetal (2.67%, tissues. In tissues from 14 organs, the difference expression between epithelium corresponding...
The present study aimed to investigate the prevalence and quantity of Lactobacillus species in vaginas healthy Chinese women. Vaginal samples from 92 fertile 22 postmenopausal women were analysed using a 16S rRNA gene clone library species-specific PCR followed by sequencing real-time PCR. A total 13 different detected. Species-specific showed that 3% colonized one 97% two or more species. Among women, 91% 9% In L. iners (82.61%), crispatus (70.65%) gasseri (67.39%) prevalent than jensenii...
Protein-ligand binding affinity plays an important role in drug discovery, especially during virtual screening and hit-to-lead optimization. Computational chemistry machine learning methods have been developed to investigate these tasks. Despite the encouraging performance, optimization are often studied separately by existing methods, partially because they performed sequentially discovery pipeline, thereby overlooking their interdependency complementarity. To address this problem, we...
Striatal transplantation of dopaminergic (DA) neurons or neural stem cells (NSCs) has been reported to improve the symptoms Parkinson's disease (PD), but low rate cell survival, differentiation, and integration in host brain limits therapeutic efficacy. We investigated effects intracranial co-transplantation mesencephalic NSCs stably overexpressing human glial-derived neurotrophic factor (GDNF-mNSCs) together with fetal DA 6-OHDA rat model PD. injection mNSCs labeled by contrast enhancer...
MicroRNA-183 (miR-183) has been shown to play a potential oncogenic role in colon cancer. The aim of this study was evaluate the expression miR-183 colorectal cancer (CRC) and its relevance clinicopathological characteristics patient survival.Surgical specimens tissue adjacent normal mucosa were obtained from 94 patients with CRC. relative levels measured by quantitative real-time PCR. We analyzed their correlation parameters prognostic value.The significantly higher CRC tissues than...
The present study aimed to determine the effect of microRNA (miR)‑210 on osteoarthritis (OA). expression levels miR‑210, type I and X collagen (COL1A1 COL10A1) matrix metallopeptidase 13 (MMP13) in OA normal chondrocytes were determined using reverse transcription‑quantitative polymerase chain reaction analysis. transfected with an miRNA precursor for miR‑210 or a negative control. After 3, 7, 14 21 days, examined, proliferation XTT assay protein Ki67 HIF‑3α analyzed by Western blotting....
Ulcerative colitis (UC), which is a type of inflammatory bowel disease, chronic intestinal disorder multifactorial etiology. Numerous studies have indicated an association between UC and bacteria. However, limited number regarding the expression interleukin‑17 (IL‑17) interleukin‑23 (IL‑23) in with bacteria been performed. The aim current study was to investigate gut microbiota alterations patients UC, at taxonomic levels, their relationship inflammation by analyzing protein IL‑17 IL‑23....
Evidence has demonstrated that the gut microbiota, which consists of probiotics and pathogenic microorganisms, is involved in initiation ulcerative colitis (UC) via dysregulation intestinal microflora normal immune interactions, ultimately leads to mucosal dysfunction. Irisin released from muscle cells displays anti-inflammatory effects; however, mechanisms underlying irisin-mediated effects UC have not been previously reported. In present study, mice were divided into following four groups:...
Resistant ovary syndrome (ROS) is a rare endocrine disorder characterized with hypergonadotrophic hypogonadism. Infertility common complaint of woman presenting ROS, and little progress has been made in term reproduction the patient's own gamete. So far only one case report live birth reported after vitro maturation (IVM) oocytes patient suffering from ROS 2013. A secondary infertile 33 years-old was manifested oligomenorrhea markedly increased gonadotropin levels around postmenopausal...
We conducted a case-control study in China to clarify the association between XRCC1-Arg-399Gin polymorphism and HCC risk.A total of 150 cases 158 controls were selected from May 2008 2010. XRCC1-Arg399Gin XRCC3-Thr241Met polymorphisms based upon duplex polymerase-chain-reaction with confronting-two-pair primer (PCR-CTPP) method. All analysis was performed by using STATA statistical package.A significant increased risk associated XRCC1 399Arg/Gin, heavy also found individuals XRCC3 241Met/Met...
OBJECTIVE: To assess the efficacy of Zishen Yutai Pill compared with placebo on live birth rates among women after fresh embryo transfer cycles. METHODS: We conducted a double-blind, multicenter, placebo-controlled, randomized trial to investigate whether administration would improve pregnancy outcomes undergoing in vitro fertilization or intracytoplasmic sperm injection. The primary outcome was rate. Secondary were implantation, biochemical pregnancy, clinical loss, cycle cancellation, and...
Ovarian aging results in reactive oxygen species accumulation and mitochondrial deterioration. During the process, GRSF1 deficiency attenuates function granulosa cells.
Basigin, which has four isoforms, been demonstrated to be involved in progression of various human cancers. The aim this study was examine the prognostic value basigin-2 protein expression epithelial ovarian cancer. Furthermore, function cancer further investigated cell culture models.Immunohistochemistry staining performed investigate a total 146 tissue specimens. Kaplan Meier analysis and Cox proportional hazards model were applied assess relationship between progression-free survival...
Central obesity (CO) is a defining characteristic of polycystic ovary syndrome (PCOS) and PCOS-induced disorders are likely to be exacerbated in the presence CO. This study aims evaluate impact CO on infertile women with PCOS undergoing vitro fertilization (IVF).It retrospective case–control study. One hundred eighty-eight IVF were divided into group (n = 70, waist circumference [WC] ≥80 cm) noncentral (NCO) 118, WC <80 cm). Baseline characteristics, parameters ovarian stimulation...
The present study was designed to determine whether the Thinprep plus Papanicolaou stain (Thinprep) method is more sensitive than Cytospin-coupled Wright-Giemsa (WG) (Cytospin) in diagnosis of leptomeningeal metastasis (LM) from malignant solid tumors cerebrospinal fluid (CSF). We also explored if could be used differential type primary tumor cells based on morphology CSF samples.The morphological features fresh samples were analyzed using both methods. cell detection rates compared between...
Introduction: Endometriosis, the most common gynecological disorder, is a challenging disease observed in 20% -40% of subfertile women.Material and Methods: 380 women were divided into four groups.Group A consisted 176 with pelvic endometriosis.Group B 125 who had previously undergone laparoscopic endometrioma cystectomy.Group C 38 recurrent endometriomas without aspiration before IVF-ET/ICSI.Group D 41 IVF-ET/ICSI.Results: Baseline FSH level (8.61 ± 3.42 mIU/mL) total dose Gn (2337.15±...
MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. We explored whether connexin 43 (Cx43) was differently expressed in luteinized granulosa cells from women with polycystic ovary syndrome (PCOS) compared a normal menstrual cycle, and certain miRNAs the Cx43 level gap junctional intercellular communication (GJIC). The miRNA profile investigated ovarian cortex tissues five PCOS without using microarray. levels of miR-130b mRNA were...
This study investigated the impact of maternal high-fat diet on vascular function and endothelial homeostasis in offspring. We found that offspring exposed to exhibited elevated blood pressure, impaired abdominal aortic function, imbalance. These changes were accompanied by increased levels reactive oxygen species (ROS) upregulation pro-inflammatory cytokines (including IL-1β, TNF-α, IL-6, IL-10). Treatment with NLRP3 or IL-1β inhibitors prevented deterioration reduced NO production,...