A5028399899- Pancreatic and Hepatic Oncology Research
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
- Multiple Sclerosis Research Studies
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Chemokine receptors and signaling
- Neuroendocrine Tumor Research Advances
- 14-3-3 protein interactions
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Biomarkers in Disease Mechanisms
- Lung Cancer Research Studies
- Molecular Communication and Nanonetworks
- Radiation Therapy and Dosimetry
- Axon Guidance and Neuronal Signaling
- ATP Synthase and ATPases Research
- DNA Repair Mechanisms
- Light effects on plants
- Microfluidic and Bio-sensing Technologies
Oryzon Genomics (Spain)
2015-2022
Cornell University
2015-2022
ORCID
2020-2021
Candiolo Cancer Institute
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2018
University of Turin
2017
CRUK/MRC Oxford Institute for Radiation Oncology
2010-2015
University of Oxford
2010-2015
Science Oxford
2015
Churchill Hospital
2013-2014
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction where the stromal compartment often accounts for more than half of tumor volume. stellate cells (PSC) are central mediator desmoplasia. There increasing evidence that desmoplasia contributing to poor therapeutic response PDAC. We show PSCs promote radioprotection and stimulate proliferation in pancreatic cancer (PCC) direct coculture. Our vivo studies PSC-dependent single dose fractionated radiation....
// Serena Lunardi 1 , Nigel B. Jamieson 2 Su Yin Lim Kristin L. Griffiths 3 Manuela Carvalho-Gaspar Osama Al-Assar Sabira Yameen Ross C. Carter Colin J. McKay Gabriele Spoletini 4 Stefano D’Ugo Michael A. Silva Owen Sansom 5 Klaus-Peter Janssen 6 Ruth Muschel 1, * Thomas Brunner 7, Gray Institute for Radiation Oncology and Biology, Department of Oncology, University Oxford, OX3 7DQ, United Kingdom West Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, G31 2ER, Jenner...
Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence cancer (PCCs) and its expression correlates with infiltration regulatory T (Tregs) poor survival. Thus, stromal can promote immunosuppression tumor progression, through IP-10.
The concept of cancer stem cells is generally accepted in different malignancies. We have previously shown that the MDA-MB231 breast were more radiation resistant when sorted for two cell markers CD24 and ESA. In this study, we examined a possible mechanism might underlie phenotype by looking at cycle profile effect has on DNA repair pathways. showed there CD24- ESA+ S- G2-phases compared with unsorted cells, 60 38% respectively. Cyclin D E protein levels supported highlighted involvement...
Reliably predicting in vivo efficacy from vitro data would facilitate drug development by reducing animal usage and guiding dosing human clinical trials. However, such prediction remains challenging. Here, we built a quantitative pharmacokinetic/pharmacodynamic (PK/PD) mathematical model capable of xenograft models tumor growth while trained almost exclusively on cell culture sets. We studied chemical inhibitor LSD1 (ORY‐1001), lysine‐specific histone demethylase enzyme with epigenetic...
The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well its ability to counteract relevant signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified cancer, a p140Cap-positive status associates significantly lower probability of developing distant event, and clear difference survival. dampens ERBB2-positive progression, impairing onset growth the NeuT mouse model, counteracting...
Abstract Small cell lung cancer (SCLC), which comprises 15% of neoplasms, is an aggressive malignancy with limited treatment options. Survival in refractory settings typically less than one year, exemplifying the need for more effective therapeutics. Recent published results suggest that epigenetic modulation mediated by Lysine Specific Demethylase-1 (LSD1) inhibition can impact this disease setting (Mohammed et al., Cell, 2015 28(1):57-69). RG6016 a potent and selective inhibitor LSD1...
Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes regulate expression genes involved in onset and progression diseases such cancer, central nervous system (CNS) disorders, viral infections, others. Vafidemstat (ORY-2001) clinical stage inhibitor development for treatment neurodegenerative psychiatric diseases. However, role ORY-2001 targeting neuroinflammation remains to...
290 Background: Pancreatic ductal adenocarcinoma is characterized by an abundant desmoplastic reaction driven pancreatic stellate cells (PSCs) that contributes to tumor progression. Here we sought characterize the interactions between cancer (PCCs) and PSCs affect inflammatory immune response in tumors. Methods: Conditioned media from mono- cocultures of PCCs were assayed for expression cytokines, chemokines growth factors. Gene analysis human samples was used verify cytokines their...
Supplementary Figures 1-7 from Pancreatic Stellate Cells Radioprotect Cancer through β1-Integrin Signaling
Supplementary Figures 1-7 from Pancreatic Stellate Cells Radioprotect Cancer through β1-Integrin Signaling
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction where the stromal compartment often accounts for more than half of tumor volume. Pancreatic stellate cells (PSC) are central mediator desmoplasia. There increasing evidence that desmoplasia contributing to poor therapeutic response PDAC. We show PSCs promote radioprotection and stimulate proliferation in pancreatic cancer (PCC) direct coculture. Our <i>in...
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction where the stromal compartment often accounts for more than half of tumor volume. Pancreatic stellate cells (PSC) are central mediator desmoplasia. There increasing evidence that desmoplasia contributing to poor therapeutic response PDAC. We show PSCs promote radioprotection and stimulate proliferation in pancreatic cancer (PCC) direct coculture. Our <i>in...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is characterised by a strong desmoplasmic reaction where the stromal compartment encounts for up to half tumour volume. The enriched stroma believed be contributing factor poor therapeutic response of PDAC, which reflected in only 13% surviving first year after diagnosis. A central mediator desmoplastic pancreatic stellate cells (PSC). Signalling between PSC and stimulates proliferation migration both cell types as well secretion...