A5018580780- Neuroblastoma Research and Treatments
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Erythrocyte Function and Pathophysiology
- Hippo pathway signaling and YAP/TAZ
- Pluripotent Stem Cells Research
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Lipid metabolism and biosynthesis
- 14-3-3 protein interactions
- ATP Synthase and ATPases Research
- Lipoproteins and Cardiovascular Health
- Epigenetics and DNA Methylation
- Ion channel regulation and function
- Protein Kinase Regulation and GTPase Signaling
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
University of Turin
2017-2023
Candiolo Cancer Institute
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2018
Abstract The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with favorable prognosis. Here we highlight function of orchestrating local and systemic tumor-extrinsic events that eventually result inhibition the polymorphonuclear myeloid-derived cell creating an immunosuppressive tumor-promoting environment primary tumor, premetastatic niches at distant sites. Integrative transcriptomic preclinical studies unravel controls epistatic axis where, through upstream...
The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well its ability to counteract relevant signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified cancer, a p140Cap-positive status associates significantly lower probability of developing distant event, and clear difference survival. dampens ERBB2-positive progression, impairing onset growth the NeuT mouse model, counteracting...
Abstract Neuroblastoma is the most common extra-cranial pediatric solid tumor, responsible for 13–15% of cancer death. Its intrinsic heterogeneity makes it difficult to target successful therapy. The adaptor protein p140Cap/SRCIN1 negatively regulates tumor cell features and limits breast progression. This study wish assess if p140Cap a key biological determinant neuroblastoma outcome. RNAseq profiles large cohort patients show that SRCIN1 mRNA levels are an independent risk factor inversely...
Abstract p140Cap is an adaptor protein involved in assembling multi-protein complexes regulating several cellular processes. acts as a tumor suppressor breast cancer (BC) and neuroblastoma patients, where its expression correlates with better prognosis. The role of metabolism remains largely unknown. Here we study the modulation mevalonate (MVA) pathway BC cells. MVA responsible for biosynthesis cholesterol non-sterol isoprenoids often deregulated cancer. We found that both vitro vivo, cells...
The NMDARs are key players in both physiological and pathologic synaptic plasticity because of their involvement many aspects neuronal transmission as well learning memory. contribution these events different types GluN2A-interacting proteins is still unclear. p140Cap scaffold protein acts a hub for postsynaptic complexes relevant to psychiatric neurologic disorders regulates functions, such the stabilization mature dendritic spine, memory consolidation, LTP, LTD. Here we demonstrate that...
An amendment to this paper has been published and can be accessed via a link at the top of paper.