A5091582088- Antiplatelet Therapy and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Pharmacology and Obesity Treatment
- Diabetes Treatment and Management
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Platelet Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Metabolism, Diabetes, and Cancer
- Venous Thromboembolism Diagnosis and Management
- Renin-Angiotensin System Studies
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Peptidase Inhibition and Analysis
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
- Antioxidant Activity and Oxidative Stress
University of Turin
2016-2025
Sofia University
2024
Monash University
2019-2023
Kemerovo State University
2023
Université de Strasbourg
2023
Inserm
2023
Australian Regenerative Medicine Institute
2020
Retina Clinic
2019
Candiolo Cancer Institute
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2018
Glucagon-like peptide 1 (GLP-1) is object of intensive investigation for not only its metabolic effects but also the protective vascular actions. Since platelets exert a primary role in pathogenesis atherosclerosis, inflammation and complications, we investigated whether GLP-1 directly influences platelet reactivity. For this purpose, from 72 healthy volunteers evaluated receptor (GLP-1R) expression 15-minute incubation with native form GLP-1(7-36), N-terminally truncated GLP-1(9-36)...
It is commonly believed that gastrointestinal issues during exercise are exacerbated by hypohydration. This study aimed to determine the effect of exercise-induced hypohydration on integrity, function, symptoms, and systemic endotoxin inflammatory profiles. In a randomized crossover design, male endurance runners (n = 11) performed 2 h running at 70% maximum oxygen uptake in 25°C ambient temperature with water provision [euhydration (EuH)] total restriction [hypohydration (HypoH)] running,...
Strenuous exercise is synonymous with disturbing gastrointestinal integrity and function, subsequently prompting systemic immune responses exercise-associated symptoms, a condition established as "exercise-induced syndrome." When stress aligned exacerbation factors (i.e., extrinsic intrinsic) are of substantial magnitude, these perturbations can cause performance decrements health implications clinical significance. This potentially explains the exponential growth in exploratory,...
Central obesity shows impaired platelet responses to the antiaggregating effects of nitric oxide (NO), prostacyclin, and their effectors—guanosine 3′,5′‐cyclic monophosphate (cGMP) adenosine (cAMP). The influence weight loss on these alterations is not known. To evaluate whether a diet‐induced body‐weight reduction restores sensitivity physiological agents reduces activation in subjects affected by central obesity, we studied 20 centrally obese before after 6‐month diet intervention aiming...
Background . Beside the lipid-lowering effect, statins slow progression of atherosclerosis by exerting anti-inflammatory and platelet inhibiting effects. We investigated whether inhibition simvastatin correlates with statin effects on lipid lowering, inflammation, oxidative stress, endothelial activation. Methods. In hypercholesterolemic patients allocated to diet (n=20) or a 2-month treatment plus 40 mg (n=25), we evaluated aggregating responses ADP, collagen, arachidonic acid (AA), effect...
Background: Proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) lower LDL-cholesterol and slow atherosclerosis preventing cardiovascular events. While it is known that circulating PCSK9 enhances platelet activation (PA) PCSK9i reduce it, the underlying mechanism not still clarified. Methods: In a multicenter before–after study in 80 heterozygous familial hypercholesterolemia (HeFH) patients on treatment with maximum tolerated statin dose ± ezetimibe, PA, soluble-NOX2-derived...
Beyond the regulation of cholesterol metabolism, a number extrahepatic functions proprotein convertase subtilisin/kexin type 9 (PCSK9) have been increasingly identified. The main purpose this study was to verify whether PCSK9 expression in vascular smooth muscle cells (VSMC) is influenced by insulin resistance and high glucose (HG). In cultured rat aortic VSMC from lean insulin-sensitive Zucker rats (LZRs) obese insulin-resistant (OZRs), classical animal model resistance, we evaluated with...
In cultured human vascular smooth muscle cells, insulin increases cyclic GMP production by inducing nitric oxide (NO) synthesis. The aim of the present study was to determine whether in these cells insulin-stimulated NO/cyclic pathway plays a role regulation glucose uptake.Glucose transport measured as uptake 2-deoxy-d-[3H]glucose, synthesis checked radioimmunoassay, and GLUT4 recruitment into plasma membrane determined immunofluorescence. Insulin-stimulated were blocked an inhibitor NO...
We aimed to evaluate whether insulin influences vascular endothelial growth factor (VEGF) synthesis and secretion in cultured smooth muscle cells (VSMCs) via nitric oxide (NO) these putative effects are lost insulin-resistant states.In VSMC derived from human arterioles aortas of insulin-sensitive Zucker fa/+rats fa/fa rats incubated with different concentrations regular or without inhibitors phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3-K), mitogen-activated protein kinase (MAPK),...
A major challenge in the neuroscience field is identification of molecules and pathways that control synaptic plasticity memory. Dendritic spines play a pivotal role these processes, as sites excitatory synapses neuronal communication. Previous studies have shown scaffold protein p140Cap localizes into dendritic its knockdown negatively modulates spine shape culture. However, so far, there no information on vivo relevance. By using knock-out mouse model, we here demonstrate key element for...
The study aimed to determine the test-retest reliability of exercise-induced gastrointestinal syndrome (EIGS) biomarkers, and assess association pre-exercise short chain fatty acid (SCFA) concentration with these biomarkers in response prolonged strenuous exercise. Thirty-four participants completed 2 h high-intensity interval training (HIIT) on two separate occasions at least 5-days washout. Blood samples were collected pre- post-exercise, analysed for associated EIGS [i.e., cortisol,...
The role of antiplatelet therapy in patients with acute coronary syndromes is a moving target considerable novelty the last few years. pathophysiological basis treatment depends on platelet biology and physiology, interplay between these aspects clinical practice must guide physician determining best therapeutic options for syndromes. In present narrative review, we discuss latest novelties We start description main signal pathways involved aggregation during an syndrome. Then, evidence...