A5019482090- Bone Tissue Engineering Materials
- Biofield Effects and Biophysics
- Reproductive Biology and Fertility
- Vitamin D Research Studies
- Electromagnetic Fields and Biological Effects
- Oral microbiology and periodontitis research
- Bone health and osteoporosis research
- Ovarian function and disorders
- Endodontics and Root Canal Treatments
- Laser-Ablation Synthesis of Nanoparticles
- Occupational and environmental lung diseases
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- thermodynamics and calorimetric analyses
- Dental Implant Techniques and Outcomes
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Sperm and Testicular Function
- Corneal Surgery and Treatments
- Retinal and Macular Surgery
- Fluoride Effects and Removal
- Nitric Oxide and Endothelin Effects
- Pancreatic and Hepatic Oncology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University of Turin
2014-2025
Pediatrics and Genetics
2007
Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D. Recently, the mitochondrial have been characterized in cell types. In this article, we investigated importance VDR not only activity integrity but also health. The silencing different healthy, non-transformed, cancer cells initially decreased growth modulated cycle. We demonstrated that, silenced cells, increased respiratory was associated with elevated reactive oxygen species (ROS) production. long run,...
Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug‐resistant malaria. In present work we show that artemisinin shares with other sesquiterpene lactones ability to inhibit activation nuclear factor NF‐kB: by this mechanism, artemisinin, well parthenolide, inhibits nitric oxide synthesis cytokine‐stimulated human astrocytoma T67 cells. These results suggest addition its antiparasitic properties, could also exert therapeutic effect on...
The metabolic actions of the ghrelin gene-derived peptide obestatin are still unclear. We investigated effects in vitro, on adipocyte function, and vivo, insulin resistance inflammation mice fed a high-fat diet (HFD). Obestatin apoptosis, differentiation, lipolysis, glucose uptake were determined vitro mouse 3T3-L1 human subcutaneous (hSC) omental (hOM) adipocytes. In influence metabolism was assessed an HFD for 8 wk. 3T3-L1, hSC, hOM preadipocytes adipocytes secreted showed specific binding...
Abstract Background Artificial Intelligence entails the application of computer algorithms to huge and heterogeneous amount morphodynamic data produced by Time-Lapse Technology. In this context, Machine Learning (ML) methods were developed in order assist embryologists with automatized objective predictive models able standardize human embryo assessment. study, we aimed at developing a novel ML-based strategy identify relevant patterns associated prediction blastocyst development stage on...
Inflammation involving the innate and adaptive immune systems is a normal response to infection; however, when allowed continue unchecked, inflammation may result in several pathologies. Natural molecules with antioxidant properties can target key players of exert beneficial health effects. In this study, human bronchial (Beas-2B) prostate (HPrEpiC) epithelial cell lines were exposed infectious stimulation treated phycocyanin (PC) palmitoylethanolamide (PEA), aim demonstrating enhanced...
In cultured human vascular smooth muscle cells, insulin increases cyclic GMP production by inducing nitric oxide (NO) synthesis. The aim of the present study was to determine whether in these cells insulin-stimulated NO/cyclic pathway plays a role regulation glucose uptake.Glucose transport measured as uptake 2-deoxy-d-[3H]glucose, synthesis checked radioimmunoassay, and GLUT4 recruitment into plasma membrane determined immunofluorescence. Insulin-stimulated were blocked an inhibitor NO...
RFamide peptides 43RFa and 26RFa have been shown to promote food intake exert different peripheral actions through G-protein-coupled receptor 103 (GPR103) binding. Moreover, was found inhibit pancreatic insulin secretion, whereas the role of on β-cell function is unknown, as well effects both survival. Herein, we investigated survival apoptosis β-cells human islets. In addition, explored these secretion underlying signaling mechanisms. Our results show that in INS-1E islets prevented cell...
Age-related macular degeneration (AMD) is strictly linked to chronic oxidative stress, inflammation, loss of epithelial barrier integrity, and often with abnormal new blood vessel development. In this study, the retinal cell line ARPE-19 was treated pro-inflammatory transforming growth factor-beta (TGF-β) investigate activity vitamin D (VD) sulforaphane (SF) in abating consequences stress inflammation. The administration VD SF lowered reactive oxygen species (ROS) levels, abated related...
Purpose: This literature review synthetizes current evidence on the timing and efficacy of dexamethasone intravitreal injections for diabetic macular edema (DME) in patients undergoing cataract surgery, particularly phacoemulsification, to determine optimal improved outcome. Methods: A systematic was conducted across key databases identify peer-reviewed studies, clinical trials, meta-analyses addressing administered pre-, intra-, post-operatively DME context surgery. Studies were selected...
Visceral fat mass is associated with a condition of chronic inflammation and can predispose the overweight to an increased cancer risk. Although it known that adipocytes are active producers pro-inflammatory transforming growth factor β (TGFβ), causes their excessive synthesis not clear. In this study, we reproduced two metabolic stress conditions frequently occurring in vivo, namely hypoxia fatty acid-driven uncoupling, characterized response vitro model 3T3-L1 mouse adipocytes. For first...
Asbestos exposure increases the risk of asbestosis and malignant mesothelioma (MM). Both fibrosis cancer have been correlated with Epithelial to Mesenchymal Transition (EMT)—an event involved in fibrotic development progression. During EMT, epithelial cells acquire a mesenchymal phenotype by modulating some proteins. Different factors can induce but Transforming Growth Factor β (TGF-β) plays crucial role promoting EMT. In this work, we verified if EMT could be associated MM development. We...
We previously established a thermodynamical model to calculate the specific frequencies of extremely low frequency-electromagnetic field (ELF-EMF) able arrest growth cancer cells. In present study, for first time, we investigated efficacy this technology on osteosarcoma, and applied precise frequency electromagnetic three human osteosarcoma cell lines, grown as adherent cells spheroids. evaluated antitumour irradiation in terms response chemotherapeutic treatments, which is usually poor type...