A5063796948- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Allergic Rhinitis and Sensitization
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Salivary Gland Disorders and Functions
- Olfactory and Sensory Function Studies
- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- Dermatology and Skin Diseases
- Advanced Glycation End Products research
- Connexins and lens biology
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- melanin and skin pigmentation
- Acne and Rosacea Treatments and Effects
- Nasolacrimal Duct Obstruction Treatments
- Ophthalmology and Eye Disorders
- Ocular Diseases and Behçet’s Syndrome
- Traumatic Ocular and Foreign Body Injuries
- Urticaria and Related Conditions
- Anesthesia and Pain Management
University of Messina
2016-2025
Istituto Ortopedico Gaetano Pini
2020
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2008-2017
Associazione Nazionale Medici Cardiologi Ospedalieri
2017
Policlinico Universitario di Catania
2017
Medical University of Silesia
2016
Institute of Ophthalmology
2016
Aristotle University of Thessaloniki
2016
Instytut Kolejnictwa
2014
University of Padua
1988-2009
Dry eye disease (DED), a multifactorial of the tears and ocular surface, is common has significant impact on quality life. Reduced aqueous tear flow and/or increased evaporation phase leads to hyperosmolarity, key step in vicious circle DED pathology. Tear hyperosmolarity gives rise morphological changes such as apoptosis cells conjunctiva cornea, triggers inflammatory cascades that contribute further cell death, including loss mucin-producing goblet cells. This exacerbates film instability...
PurposeTo evaluate the safety and efficacy of topical recombinant human nerve growth factor (rhNGF) for treating moderate-to-severe neurotrophic keratitis (NK), a rare degenerative corneal disease resulting from impaired innervation.DesignPhase II multicenter, randomized, double-masked, vehicle-controlled trial.ParticipantsPatients with stage 2 (moderate) or 3 (severe) NK in 1 eye.MethodsThe REPARO phase study assessed 156 patients randomized 1:1:1 to rhNGF 10 μg/ml, 20 vehicle. Treatment...
Dry eye disease (DED) is a distressing ocular condition. Due to its multifactorial nature, clinical and biological signs of DED can be inconsistent sometimes discordant with symptomatology. Consequently, no gold-standard model for determining severity exists. This impact treatment decisions complicate evaluation progression, particularly within the stringent context trials. The multinational ODISSEY European Consensus Group comprised ophthalmologists who contend surface issues on daily...
<i>Pseudomonas aeruginosa</i> is a major cause of nosocomial respiratory infections. The eradication <i>P. from the lung involves orchestrated actions pulmonary epithelium and both resident recruited immune cells. NKG2D receptor constitutively expressed on surface circulating tissue-resident NK cells (and other cytotoxic lymphocytes), capable controlling cell activation production cytokines, such as IFN-γ via interactions with ligands stressed Previously, we demonstrated that mediates...
Meibomian gland dysfunction (MGD) is a common and chronic disorder that has significant adverse impact on patients' quality of life. It leading cause evaporative dry eye disease (DED), as meibomian glands play an important role in providing lipids to the tear film, which helps retard evaporation tears from ocular surface. MGD also often present conjunction with primary aqueous-deficient DED. Obstructive MGD, most commonly observed type main focus this article. probably caused by combination...
Purpose: To determine whether oral supplementation with omega-3 and omega-6 fatty acids can reduce conjunctival epithelium expression of the inflammatory marker human leucocyte antigen-DR (HLA-DR) in patients dry eye syndrome (DES). Methods: This 3-month, double-masked, parallel-group, controlled study was conducted nine centres, France Italy. Eligible adult mild to moderate DES were randomized receive a placebo containing medium-chain triglycerides or treatment supplement acids, vitamins...
Abstract To evaluate the ocular manifestation in patients hospitalized with coronavirus disease 2019 (COVID-19) and to search for presence of severe acute respiratory syndrome 2 (SARS-CoV-2) tears. This study was conducted 29 who were admitted COVID center at Policlinic Hospital University Messina, Italy. All underwent an ophthalmologic assessment comprising a Standardized Patient Evaluation Eye Dryness (SPEED) questionnaire, anterior segment, surface examination both eyes using portable...
<b>Aim:</b> To study the effect of treatment dry eye in Sjögren9s syndrome patients with hypotonic or isotonic hyaluronate drops. <b>Methods:</b> 40 were divided two groups and treated as follows: group 1 (150 mOsm/l) 0.4% drops; 2 The drops instilled six times a day for 90 days. Grading subjective symptoms, break up time (BUT), corneal fluorescein staining, conjunctival rose bengal Schirmer9s I test, impression cytology carried out at 0 15, 30, days from beginning study. Patients examined...
To determine the effect of oral omega-6 essential fatty acids on PGE(1) tear content and signs symptoms ocular discomfort in patients with Sjögren's syndrome (SS).This randomized, double-masked, controlled, clinical trial involved 40 primary SS, divided into two groups: group 1: 20 (18 women, 2 men; mean age, 36.9 +/- 7.9 years [SD]) treated for 1 month linoleic acid (LA; 112 mg), gamma-linolenic (GLA; 15 mg) administered twice daily; 2: (19 man; 36.3 5.5 years) daily placebo. Patients...
<h3>Purpose</h3> Vernal keratoconjunctivitis (VKC) is a chronic, allergic, and potentially severe ocular disease affecting children adolescents that can lead to impaired quality of life (QoL) loss vision. This study evaluated the efficacy safety an investigational therapy for VKC, cyclosporine A (CsA) cationic emulsion (CE), oil-in-water with increased bioavailability versus conventional CsA formulations. <h3>Design</h3> The VErnal KeratoconjunctiviTIs Study (VEKTIS) phase 3, multicenter,...
Purpose: To assess the physicochemical properties of hyaluronic acid (HA)-based artificial tears. Methods: The average molecular weight (MW) and polydispersion index (PDI) HA in 18 commercially available tears were determined by light scattering/high-performance liquid chromatography. Osmolality, pH, viscosity, sodium concentration using an osmometer, pH meter, rheometer, inductively coupled plasma mass spectrometer, respectively. Results: MW varied considerably between formulations. PDI was...
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1Mastropasqua L. Massaro-Giordano G. Nubile M. Sacchetti Understanding the pathogenesis of neurotrophic keratitis: role nerves.J Cell Physiol. 2017; 232: 717-724Crossref PubMed Scopus (83) Google Scholar Because NK pathology involves trigeminal nerve damage and loss innervation, growth factor (NGF) is surmised to promote healing NK.2Lambiase A. Mantelli F. et al.Clinical...
Purpose: To evaluate the frequency and epidemiological features of vernal keratoconjunctivitis (VKC) in Italy. Methods: a specific electronic clinical chart for was created to standardize: 1) medical history; 2) diagnostic criteria; 3) signs symptoms; 4) treatments. This study involved 6 Italian referral centers ocular surface diseases: between March 2005 2006, all referred patients were included, data collected statistically examined. Results: The mean age population (n = 156) 13.8 ± 8.8...