A5020894481- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Urticaria and Related Conditions
- Ophthalmology and Visual Impairment Studies
- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Cell Adhesion Molecules Research
- Herpesvirus Infections and Treatments
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Contact Dermatitis and Allergies
- Ocular Oncology and Treatments
- Optical Coherence Tomography Applications
- Allergic Rhinitis and Sensitization
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bacterial biofilms and quorum sensing
- Inflammasome and immune disorders
- Retinal Development and Disorders
University of Southampton
2013-2024
University Hospital Southampton NHS Foundation Trust
2014-2024
Southampton General Hospital
2011-2024
Southampton Hospital
2023
Aristotle University of Thessaloniki
2023
Hampton University
2023
NIHR Wellcome Trust Southampton Clinical Research Facility
2014
Queen's Medical Centre
2000-2004
University of Nottingham
1999-2004
University of Aberdeen
1991-1998
PurposeTo evaluate the safety and efficacy of topical recombinant human nerve growth factor (rhNGF) for treating moderate-to-severe neurotrophic keratitis (NK), a rare degenerative corneal disease resulting from impaired innervation.DesignPhase II multicenter, randomized, double-masked, vehicle-controlled trial.ParticipantsPatients with stage 2 (moderate) or 3 (severe) NK in 1 eye.MethodsThe REPARO phase study assessed 156 patients randomized 1:1:1 to rhNGF 10 μg/ml, 20 vehicle. Treatment...
To determine the presenting features of ocular surface disease in patients with atopic dermatitis (AD) treated dupilumab at a tertiary, university hospital. establish need for treatment dupilumab-associated and report any long-term effects on surface.
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1Mastropasqua L. Massaro-Giordano G. Nubile M. Sacchetti Understanding the pathogenesis of neurotrophic keratitis: role nerves.J Cell Physiol. 2017; 232: 717-724Crossref PubMed Scopus (83) Google Scholar Because NK pathology involves trigeminal nerve damage and loss innervation, growth factor (NGF) is surmised to promote healing NK.2Lambiase A. Mantelli F. et al.Clinical...
Abstract: Corneal confocal microscopy is a novel clinical technique for the study of corneal cellular structure. It provides images which are comparable to in-vitro histochemical techniques delineating epithelium, Bowman's layer, stroma, Descemet's membrane and endothelium. Because, non invasive in vivo imaging living cornea it has huge potential investigate numerous diseases. Thus far been used detection management pathologic infectious conditions, dystrophies ecstasies, monitoring contact...
ObjectivesTo compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml) + propamidine 0.1% (1 [PHMB 0.02%+propamidine] to 0.08% (0.8 with placebo 0.08%] for Acanthamoeba keratitis (AK) treatment.DesignProspective randomized, double-masked, active-controlled, multicentre, Phase3 study (ClinicalTrials.gov NCT03274895).Participants135 at six European centres between 08/17/2017 06/18/2021.MethodsPrincipal inclusion criteria: ≥12 years old; in vivo confocal microscopy (IVCM) clinical findings...
Objective To evaluate the relationship, over time, between central graft thickness and visual acuity following Descemet's stripping endothelial keratoplasty (DSEK). Methods A retrospective analysis of 70 consecutive cases DSEK. All donor lenticules were dissected manually. Serial postoperative measurements total corneal thicknesses made using anterior segment optical coherence tomography. Visual acuity, refraction patient demographics collected from case notes. The correlation at serial time...
Bimatoprost ophthalmic solution 0·03% is approved in several countries for the treatment of eyelash hypotrichosis. Previous trials were limited to 4 months and primarily idiopathic hypotrichosis.To evaluate long-term safety efficacy bimatoprost patients with or chemotherapy-induced hypotrichosis.This multicentre, double-masked, randomized, parallel-group study included two 6-month periods [treatment period 1 (TP1) 2 (TP2)]. Patients hypotrichosis randomized three groups: (i) (TP1 TP2); (ii)...
Microbial keratitis is a sight-threatening complication of contact lens wear, which affects thousands patients and causes significant burden on healthcare services. This study aims to identify compliance with care recommendations personal hygiene risk factors in who develop lens-related microbial keratitis.A case-control was conducted at the University Hospital Southampton Eye Casualty from October December 2015. Two participant groups were recruited: cases wearers presenting controls...
Objectives To compare sociodemographics and vision-related quality of life (QoL) individuals with or without dry eye disease (DED); to explore the impact DED symptom severity on visual function, activity limitations work productivity. Design Cross-sectional web-based survey. Setting General UK population. Participants Adults ≥18 years (N=1002) (N=1003) self-reported recruited through email screened. Main outcome measures All participants completed 25-item National Eye Institute Visual...
purpose. To investigate the expression of CD34, a hematopoietic stem cell marker and an adhesion molecule, its ligand L-selectin in human cornea. methods. Seventeen normal adult corneal specimens were studied by immunohistochemistry using panel monoclonal antibodies against all three classes CD34 L-selectin. An additional six used for protein extraction analysis Western blotting, antibodies. PCR was to determine mRNA specimens. results. Only keratocytes showed positive immunostaining CD34....
To quantify the human corneal inflammatory response in treated bacterial keratitis with long-wavelength anterior segment optical coherence tomography (AS-OCT).Patients clinically suspected were recruited from service at Southampton Eye Unit, UK. Patients underwent AS-OCT and slit-lamp examination on presentation (day 0) days 3, 7, 14 of treatment. Corneal thickness (CT) infiltrated area, infiltrate (IT), width (IW) measured high-resolution scans. Mean values for each day rates change...
Corneal neovascularisation (CoNV) can lead to significant ocular comorbidity with reduction in vision and cosmesis. A number of techniques have been described reduce CoNV, but these be expensive. Our study aimed determine the safety, efficacy long-term outcomes fine needle diathermy (FND) for CoNV.A 5-year retrospective identified all cases FND. Indications, intraoperative complications, postoperative visual acuity, after treatment retreatments, were documented, along procedure time....
Toll-like receptor 4 (TLR4) is a key component of the innate immune response related to microbial keratitis (MK). Pathways and downstream effectors relating TLR signaling remain unknown in human bacterial MK. To this effect, by activating TLR4 cascade with lipopolysaccharide (LPS), authors investigated whether TLR4, matrix metalloproteases (MMP)-2, MMP-9, cytokine expression diseased primary corneal fibroblasts (CFs) were altered.Human CFs from patients severe ulceration cultured conjunction...
Background Corneal graft (CG) surgery is the most common and successful tissue transplant worldwide. A small important group of patients are operated in emergency situations, typically to save a perforated eye. Our knowledge indications outcomes corneal (eCG) limited. Methods Retrospective, multifactorial analysis all CGs registered by UK Transplant Service from April 1999 March 2005. Results total 12 976 were performed. 1330 (11.4%) eCGs including 433 regrafts. Actual perforation occurred...