A5101888695- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- Catalytic Cross-Coupling Reactions
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Phytochemistry and Bioactive Compounds
- Natural product bioactivities and synthesis
- Advanced Breast Cancer Therapies
- Microtubule and mitosis dynamics
- Thyroid Cancer Diagnosis and Treatment
- Phytochemistry and Biological Activities
- Esophageal and GI Pathology
- Sulfur-Based Synthesis Techniques
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- RNA regulation and disease
- Cyclopropane Reaction Mechanisms
- NF-κB Signaling Pathways
- interferon and immune responses
- Glutathione Transferases and Polymorphisms
- Tissue Engineering and Regenerative Medicine
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
Shanghai Chest Hospital
2008-2024
Shanghai Jiao Tong University
2024
First Affiliated Hospital of Zhengzhou University
2014-2023
Chongqing Medical and Pharmaceutical College
2019-2022
Fosun Pharma (China)
2019
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2014
Southwest University
2011-2013
Sun Yat-sen University
2012
Lu'an First People's Hospital
2004
Bis(thiazole) pincer palladium complexes showed efficient catalytic activity for the Suzuki-Miyaura coupling of aryl halides, allowing synthesis biaryls with very high turnover numbers and frequencies. The were successfully applied in scalable green key intermediates bioactive LUF5771 its analogues.
The present study aimed to determine the effect of microRNA (miR)‑210 on osteoarthritis (OA). expression levels miR‑210, type I and X collagen (COL1A1 COL10A1) matrix metallopeptidase 13 (MMP13) in OA normal chondrocytes were determined using reverse transcription‑quantitative polymerase chain reaction analysis. transfected with an miRNA precursor for miR‑210 or a negative control. After 3, 7, 14 21 days, examined, proliferation XTT assay protein Ki67 HIF‑3α analyzed by Western blotting....
Two novel NCN-pincer complex precursors bearing frameworks of 2,6-bis(oxazol-4-yl)benzene (A) and 2-(thiazol-4-yl)-6-(oxazol-4-yl)benzene (B) were synthesized. Palladations A B afforded two new bis(azole) pincer complexes, [(A-κ3NCN)PdBr] (1) [(B-κ3NCN)PdBr] (2). Both complexes fully characterized by NMR, MS, DSC-TGA single-crystal X-ray diffraction analysis. Complex 1 crystallizes in a noncentrosymmetric orthorhombic space group Cmc21 (No. 36, Z = 4). 2 centrosymmetric monoclinic groupP21/n...
Dysregulation of long intergenic non-protein coding RNA 00,641 (LINC00641) is associated with the malignancy progression multiple cancers, including thyroid carcinoma. The current study aimed to determine role LINC00641 in papillary carcinoma (PTC) and underlying mechanism. We found that was downregulated PTC tissues cells(p < 0.05), overexpression inhibited cell proliferation invasion, induced apoptosis(p while silencing promoted invasion cells, 0.05). Furthermore, we Glioma-associated...
Thyroid cancer is an endocrine malignancy with a high incidence rate, which affected by female hormones, particularly estrogens, in its growth and progression. IQ-domain GTPase‑activating protein 1 (IQGAP1) overexpressed range of types reported to interact estrogen receptor α (ERα) breast cells. However, the association between IQGAP1 ERα thyroid cells remains be elucidated. In this study, role was examined. The expression (190 kDa) analyzed using western blot analysis, indicated that...
Diabetic nephropathy (DN) is a leading cause of end-stage renal failure. The study aimed to investigate whether long noncoding RNA taurine-upregulated gene 1 (TUG1) can ameliorate the endoplasmic reticulum stress (ERS) and apoptosis tubular epithelial cells in DN, underlying mechanism. DN mouse model was established by streptozocin injection, human cell line HK-2 treated with high glucose (HG) mimic vitro. molecular mechanism explored through dual-luciferase activity assay, pull-down...
Lepidogrammitis drymoglossoides (Bak.) Ching is a medicinal plant that belongs to the family of Polypodiaceae. Previous phytochemical investigation on this genus had revealed presence flavonoids, sterols, and alkaloids. Here, further led isolation new ecdysteroidal glycoside, ponasteroside B (1), along with known steroidal compound, β-ecdysterone (2). The structure 1 was determined basis extensive spectroscopic analysis, including HR-MS 1D 2D NMR experiments, as well chemical hydrolysis study.
Mitochondria are not only the main energy generators of cell, but also mediate several critical biochemical processes such as apoptosis, proliferation and redox homeostasis. As such, mitochondrial dysfunctions can lead to a wide variety human diseases, including cancer osteoarthritis (OA). In OA, mitochondrial-associated signaling has been implicated in molecular events leading cartilage degradation, oxidative stress, defective chondrocyte biosynthesis growth responses, increased...
Abstract Cyclin-dependent kinase-4 (CDK4) and CDK6 form a complex with D-type cyclins to phosphorylate Retinoblastoma protein (Rb), leading loss of repression E2F transcription factors, which enables cell cycle progression from G1 S phase. Loss control caused by aberrations in CDK/Rb signaling pathway are common solid tumors. Inhibiting CDK4/6 blocks pathway, prevents through restriction point, thus arresting tumor growth. Most the 1st generation CDK inhibitors lack family selectivity,...
The major disadvantage of using a stem cell-based bone morphogenetic protein-4 (BMP4) gene therapy for skull defect is the overgrowth generated tissue in situ. In present study, to overcome bony cell based-gene therapy, new strategy two-stage engineering by an adeno-associated virus containing BMP4 (AAV-BMP4) was used. AAV-BMP4 purposely implanted skeletal muscle mice generate ectopic tissues during first stage. Next, newly formed were harvested and then transplanted repair mouse second...
ABSTRACT Background and Aims Pathogenic microbial infections are closely related to the development prognosis of esophageal cancer. The distribution resistance pathogens in different diseases regional gradually change over time. This study aimed determine drug isolated from patients with cancer provide a reference for rational use antibiotics. Methods results strain identification antimicrobial susceptibility testing January 2013 December 2022 at our hospital were retrospectively analyzed....
Abstract Increasing evidence indicated that protein arginine methyltransferase‐1 (PRMT1) is an oncogene in multiple malignant tumors, including osteosarcoma (OS). The aim of this study was to investigate the underlying mechanism PRMT1 OS. effects or BCAT1, branched‐chain amino acid transaminase 1 (BCAT1) on OS cell proliferation, invasion, autophagy, and apoptosis vitro were examined. Moreover, molecular control c‐Myc transactivation BCAT1 assessed by chromatin immunoprecipitation...
Abstract isolation, structure and cytotoxicity of the new steroidal glycoside ponasteroside B (I) along β‐ecdysterone
Objective To explore the effects of p53 upregulated modulator apoptosis(PUMA)on apoptosis in mouse knee joint osteoarthritis cartilage. Methods The cell model was made by using artificial chondrocytes treated with interleukin(IL)-1β, and small interfering RNA(siRNA) PUMA transfected into chondrocytes. The expression were detected Western blotting Hoechst staining at baseline after transfection. Results PUMA protein control group 6.11 times blank group, that 2.02 3.30...
Abstract Using the title method, key intermediate (VIII) of luteinizing hormone receptor antagonist LUF5771 can be prepared in high yields.
Cyclin-dependent kinase-4 (CDK4) and CDK6 form a complex with D-type cyclins to phosphorylate Retinoblastoma protein (Rb), leading loss of repression E2F transcription factors, which enables cell cycle progression from G1 S phase. Loss control caused by aberrations in CDK/Rb signaling pathway are common solid tumors. Inhibiting CDK4/6 blocks pathway, prevents through restriction point, thus arresting tumor growth. Most the 1st generation CDK inhibitors lack family selectivity, result greater...