A5047665269- Pregnancy and preeclampsia studies
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Pituitary Gland Disorders and Treatments
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Meningioma and schwannoma management
- Gestational Diabetes Research and Management
- Circular RNAs in diseases
- Nuclear Receptors and Signaling
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Tissue Engineering and Regenerative Medicine
- Spinal Hematomas and Complications
- Bariatric Surgery and Outcomes
- Epigenetics and DNA Methylation
- Neurogenetic and Muscular Disorders Research
- Gut microbiota and health
- Pregnancy-related medical research
Kunming Medical University
2014-2024
First Affiliated Hospital of Kunming Medical University
2010-2024
Puer University
2024
Yunnan Provincial Infectious Disease Hospital
2024
Yunnan Yingmao Biotechnology (China)
2016
Second Affiliated Hospital of Kunming Medical College
2009
Abstract Objective The association of the triglyceride-glucose (TyG) index with severe consciousness disturbance and in-hospital mortality in patients cerebrovascular disease intensive care unit (ICU) is unclear. This study aimed to investigate TyG index’s predictive ability on severity impaired ICU. Method Patients diagnosed non-traumatic cerebral hemorrhage infarction were extracted from MIMIC-IV database analyzed as two cohorts. between patients’ impairment was using logistic regression...
Striatal transplantation of dopaminergic (DA) neurons or neural stem cells (NSCs) has been reported to improve the symptoms Parkinson's disease (PD), but low rate cell survival, differentiation, and integration in host brain limits therapeutic efficacy. We investigated effects intracranial co-transplantation mesencephalic NSCs stably overexpressing human glial-derived neurotrophic factor (GDNF-mNSCs) together with fetal DA 6-OHDA rat model PD. injection mNSCs labeled by contrast enhancer...
Abstract Long noncoding RNAs (lncRNAs) and their crosstalks with other have been revealed to be closely related tumorigenesis development, but role in invasive pituitary adenoma (IPA) remains largely unclear. In our study, LINC00473 was identified as the most upregulated lncRNA IPA by whole transcriptome RNA sequencing (RNA-Seq). Further, its signaling pathway LINC00473/miR-502-3p/KMT5A obtained constructing a competing endogenous (ceRNA) regulatory network. Their expression non-invasive...
Summary Introduction Neural stem cells ( NSC s) are the most promising for cell replacement therapy Parkinson's disease PD ). However, a majority of transplanted s differentiated into glial cells, thereby limiting clinical application. Previous studies indicated that chronic neuroinflammation plays vital role in degeneration midbrain DA mDA ) neurons, which suggested developing potential therapies by targeting inflammatory processes. Thus, Nurr1 (nuclear receptor‐related factor 1),...
Background: Surgical treatment of complex giant pituitary adenomas (GPAs) presents significant challenges. The efficacy and safety combining transsphenoidal transcranial approaches for these tumors remain controversial. In this largest cohort patients with GPAs, we compared the surgical outcomes between those undergoing a combined regimen non-combined regimen. We also examined differences in risks complications, costs, logistics two groups, which might offer valuable information appropriate...
Preeclampsia is a pregnancy-specific disease, which has become an essential cause of perinatal and neonatal death. Gut microflora becomes the regulator host immunity through metabolic pathway. Epidemiological studies provide convincing evidence that vitamin D supplementation can prevent onset preeclampsia. However, research on microbial mechanisms effective treatment strategies for placental inflammation induced by lipopolysaccharide lacking. In this study, pregnant rats were LPS to...
The safety of gamma knife radiosurgery should be considered when treating pituitary adenomas.To determine the maximum tolerated dose radiation delivered by to optic nerves.An animal model designed establish prolonged balloon compression chiasm and parasellar region was developed mimic nerve caused adenomas. Twenty cats underwent surgery place a for effect 20 in sham operation group received microsurgery without any treatment. effects irradiation at 10-13 Gy on normal (sham group) compressed...
Although the incidence and clinical manifestations of pituitary apoplexy were reported by a few researches, results are not consistent. This study aimed to explore risk factors associated with an in adenomas.The information 843 patients adenoma from Department Neurological Surgery, 1st Affiliated Hospital Kunming Medical University, was reviewed. The incidence, manifestation, potential for analyzed case-control study.In total, 121 (14.4%) macroadenoma suffered apoplexy. Headache, vomiting,...
DNA methylation is the most extensively studied epigenetic modification which had been suspected to be involved in progress of gestational diabetes mellitus（GDM）. It vital investigate expression profile and GDM adipose tissue samples learn more about relationship between two profiles.Illumina Human Methylation 450 k Analysis Beadchip whole Gene Expression Array were selected screen for gene omental visceral pregnant women. Validation DMGs was conducted by bisulfate pyrosequencing DEGs q...
Abstract Background Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial rather than neurons, and only few of them survive after due to the inflammatory environment. Methods In this study, neural microglial both forced with Nurr1 gene were transplanted striatum rat model PD. The results evaluated through reverse transcription polymerase chain reaction (RT‐PCR), Western blot, immunofluorescence...
Previous studies have shown that neural stem cell transplantation has the potential to treat Parkinson's disease, but its specific mechanism of action is still unclear. Stromal cell-derived factor-1 and receptor, chemokine receptor 4 (CXCR4), are important regulators migration. We speculated CXCR4/stromal factor 1 axis may be involved in therapeutic effect treatment disease. A disease rat model was injected with 6-hydroxydopamine via right ascending nigrostriatal dopaminergic pathway, then...
During pregnancy, there is a link between disruption of maternal immune tolerance and preeclampsia, but the molecular mechanisms that regulate fetal remain unclear. This study employs bioinformatics to identify new markers related placental explore their potential role in predicting preeclampsia. Analyzing preeclampsia-related gene expression profiles Gene Expression Omnibus (GEO) dataset reveals 211 differentially expressed genes (DEGs) placenta, mainly influencing cell differentiation...
The relationship between atherosclerotic burden, depressive symptoms, and clinically relevant depression (CRD) in hypertensive patients is unclear. In this study, we used the index of plasma (AIP) to quantify burden explore its association with symptoms CRD patients.
Introduction Complete and specific ablation of a single dopaminergic (DA) pathway is critical step to distinguish the roles DA pathways in vivo. However, this kind technique has not been reported non-human primates. This study aimed establish lesioning method with complete ablation. Method A carefully designed infusion route based on MRI stereotactic was developed deliver highly selective toxin 1-methyl-4-phenylpyridinium (MPP+) unilaterally into multiple sites compact part substantia nigra...
Dysregulation of microRNAs (miRNAs) plays a critical role during the occurrence and progress pituitary adenomas (PAs). However, roles miRNAs in invasiveness PA are poorly understood. This study aims to more comprehensively specific define relationship between altered miRNA invasion.The differential expression (DEMs) invasive PAs (IPAs) non-invasive (NPAs) was explored by RNA sequencing which functions were analyzed gene ontology (GO) as well Kyoto Encyclopedia Genes Genomes (KEGG). The...
In the present study antitumor effect of 2-(4-aminophenyl) benzothiazole (BTZ) was evaluated against human U251 and rat C6 glioma cell lines using MTT assay. It observed that BTZ exhibited significant with IC50 3.5 4 µM cells respectively. To gain in-depth insights about BTZ, xenograft model prepared. The rats were treated 10 mg 15 mg/kg body weight doses daily for 21 days after administration. Treatment reduced tumor volume to 12% compared 100% in untreated rats. TUNEL assay showed a...
Abstract Heroin addiction is a public health problem that currently poses serious threat to human and global concern. Lactobacillus rhamnosus one of the most widely researched probiotics has been applied treatment multiple psychiatric disorders. We aimed explore mechanisms by which alleviated heroin based on gut microbiome metabolism. Firstly, we assessed effect intervention process using conditioned positional preference experiment (CPP) results showed significantly reduced delayed...
Growth hormone (GH) secreting pituitary adenoma is considered one of the most harmful types Pituitary Neuroendocrine Tumors (PitNETs). Our previous research has found that high expression Lysine methyltransferase 5A (KMT5A) closely related to proliferation PitNETs. The aim this study was investigate role and molecular mechanism KMT5A in progression GH