A5100418768- Intracranial Aneurysms: Treatment and Complications
- Parkinson's Disease Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroblastoma Research and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Cerebrovascular and Carotid Artery Diseases
- Botulinum Toxin and Related Neurological Disorders
- Myasthenia Gravis and Thymoma
- RNA modifications and cancer
- Neurosurgical Procedures and Complications
- Hemoglobin structure and function
- Cerebral Venous Sinus Thrombosis
- Neurofibromatosis and Schwannoma Cases
- Nuclear Receptors and Signaling
- Anesthesia and Neurotoxicity Research
- Venous Thromboembolism Diagnosis and Management
- Trace Elements in Health
- Cerebrospinal fluid and hydrocephalus
- Ubiquitin and proteasome pathways
- Acupuncture Treatment Research Studies
- Antifungal resistance and susceptibility
- Cancer-related Molecular Pathways
Argenx (Belgium)
2023-2025
China Medical University
2024
Union Hospital
2021-2023
Jilin University
2013-2023
Weatherford College
2021-2022
The University of Texas Southwestern Medical Center
2022
Southwestern Medical Center
2022
Capital Medical University
2012-2022
Beijing University of Technology
2021-2022
Third Xiangya Hospital
2022
The gene responsible for neurofibromatosis type 1 (NF1) encodes a tumor suppressor that functions as negative regulator of the Ras proto-oncogene. Individuals with germline mutations in NF1 are predisposed to development benign and malignant tumors peripheral central nervous system (CNS). Children this disease suffer high incidence optic gliomas, but potentially debilitating nerve; an increased astrocytoma, reactive astrogliosis intellectual deficits. In present study, we have sought insight...
Constipation is one of the most frequent non-motor symptoms Parkinson disease (PD) and it may be ignored by PD patients, leading to this problem not reported in time. The relationships between constipation demographic variables, motor other are still unknown. patients were evaluated diagnostic criteria functional Rome III divided into with (PD-C) no (PD-NC) groups. assessed rating scales symptoms, activity daily living quality life. frequency was 61.4%, 24.5% had before onset symptoms. PD-C...
The maintenance of highly proliferative capacity and full differentiation potential is a necessary step in the initiation stem cell-based regenerative medicine. Our recent study showed that epidermal growth factor (EGF) significantly enhanced hair follicle-derived mesenchymal cell (HF-MSC) proliferation while maintaining multilineage potentials. However, underlying mechanism remains unclear. Herein, we investigated role EGF HF-MSC proliferation. HF-MSCs were isolated cultured with or without...
Aim: To dynamically analyze the differential m6A methylation during progression and reversal of hepatic fibrosis. Materials & methods: We induced fibrosis in C57/BL6 mice by intraperitoneal injection CCl4. The model was established stopping drug after continuous Dynamic evaluated using MeRIP-Seq at different stages. Result: During fibrosis, mainly enriched processes associated with oxidative stress cytochrome metabolism, while immune response apoptosis reversal. Conclusion: plays an important role
Understanding the molecular mechanisms of Alzheimer's disease (AD) has important clinical implications for guiding therapy. Impaired amyloid beta (Aβ) clearance is critical in pathogenesis sporadic AD, and blood monocytes play an role Aβ periphery. However, mechanism underlying defective phagocytosis by AD remains unclear.
Transcranial ultrasound is a useful tool for providing the evidences early diagnosis and differential of Parkinson disease (PD). However, relationship between hyper echogenicity in substantia nigra (SN) clinical symptoms PD patients remains unknown, role dysfunction iron metabolism on pathogenesis SN unclear. was detected by transcranial sonography divided into with no (PDSN-) group (PDSN+) group. Motor (MS) non-motor (NMS) were evaluated, levels related proteins serum cerebrospinal fluid...
Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are collectively known as body (LBD). Considering the heterogeneous nature of LBD different constellations symptoms which patients can present, exact molecular mechanism underlying differences between these two isoforms is still unknown. Therefore, this study aimed to explore biomarkers potential mechanisms that distinguish PDD DLB. The mRNA expression profile dataset GSE150696 was acquired from Gene Expression Omnibus...
Studies on the pathophysiology of subdural hematomas (SDH) have been primarily focused acute phase and associated cortical injury, whereas course hematoma absorption remains poorly understood. Using a rat model SDH, we specifically investigated correlation between neovascularization membrane rate absorption. improved surgical techniques, reduced surgery-related injury increased generating successful SDH to 71.4%. With this model, demonstrate that was slow in first 4 days accelerated...
Patients with pulsatile tinnitus (PT) have unstable treatment effects after resurfacing surgery. Flow-diverting stents (FDS) are proposed as a potential method for the of PT, but therapeutic effect is not clear. This study aimed to investigate efficacy FDS in patients PT induced by sigmoid sinus diverticulum (SSD) and wall dehiscence (SSWD). In addition, we explore mechanism PT. Transient-state multiphysics coupling numerical simulation based on computed tomography angiography five was used...
This study aimed to explore new core genes related the occurrence of Parkinson's disease (PD) and that can lead progression PD. The expression profile data GSE42966, which contained six substantia nigra tissues isolated from normal individuals nine patients with PD, were obtained Gene Expression Omnibus. Differentially expressed (DEGs) identified, followed by functional enrichment analysis protein-protein interaction (PPI) network construction. We then identified 10 hub analyzed their in...
Frailty index and vestibular disorders appear to be associated in observational studies, but causality of the association remains unclear.A two-sample Mendelian randomization (MR) study was implemented explore causal relationship between frailty individuals European descent. A genome-wide (GWAS) used as exposure (n = 175, 226), whereas GWAS outcome 462,933). MR Steiger filtering method conducted investigate effect on disorders. An inverse variance weighted (IVW) approach essential examine...
This study aimed to explore the N6-methyladenosine (m6A) modification genes involved in pathogenesis of Parkinson’s disease (PD) through data analysis two sets GSE120306 and GSE22491 GEO database further its influence on cell phenotype PD. We analyzed differentially expressed function enrichment found that expression m6A-modification gene HNRNPC was significantly downregulated PD group, it played an important role DNA metabolism, RNA processing may be Then, we constructed differential line...
Background and Purpose Contrast enhanced MRA (CE-MRA) can help to overcome the limitations of other techniques clearly display details cerebral aneurysms at 1.5-T MR system. We investigated prevalence unruptured (UCAs) using three dimensional (3D) CE-MRA in a tertiary comprehensive hospital China. Materials Methods The cases were prospectively recorded our between February 2009 October 2010. 3D CE-MRA, interpreted by 2 observers blinded participants' information, was used identify location...
Intracranial infection after puncture of cerebral hematoma in patients with intracerebral hemorrhage is very common the department neurosurgery, yet relevant risks remain unknown. We attempted to analyze risk factors intracranial hematoma, provide insights into management hematoma.Patients treated our hospital from January 2017 2020 were selected, related characteristics and no compared. Logistic regression analyses conducted for hematoma.A total 925 included. The incidence postoperative was...
Introduction Complete and specific ablation of a single dopaminergic (DA) pathway is critical step to distinguish the roles DA pathways in vivo. However, this kind technique has not been reported non-human primates. This study aimed establish lesioning method with complete ablation. Method A carefully designed infusion route based on MRI stereotactic was developed deliver highly selective toxin 1-methyl-4-phenylpyridinium (MPP+) unilaterally into multiple sites compact part substantia nigra...