A5101718225- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Circular RNAs in diseases
- Reconstructive Surgery and Microvascular Techniques
- Aortic aneurysm repair treatments
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Prostate Cancer Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Diagnosis and Treatment
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Extracellular vesicles in disease
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Cancer Genomics and Diagnostics
- Aortic Disease and Treatment Approaches
Peking University
2012-2025
Peking University Cancer Hospital
2012-2025
China National Institute of Standardization
2022-2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Technion – Israel Institute of Technology
2023-2024
Tongji University
2018-2024
University of Shanghai for Science and Technology
2022-2024
Shanghai Tenth People's Hospital
2018-2024
Objective Description of the design and preliminary results baseline recruitment screening in endoscopic for esophageal cancer China (ESECC), first randomised controlled trial (RCT) assessing efficacy cost-effectiveness squamous cell carcinoma (ESCC). Design ESECC is a cluster RCT, 668 villages rural Hua County, Henan Province, high-incidence area ESCC China, were into two arms at ratio 1:1. Screening arm participants screened by Lugol chromoendoscopy; no was performed control arm....
To evaluate the effectiveness of endoscopic screening against incidence and mortality from esophageal squamous cell carcinoma (ESCC).
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease. Recent studies employing microRNA-seq and genome-wide sequencing have identified some non-coding RNAs that are influentially involved in AD pathogenesis. Non-coding can compete with other endogenous by microRNA response elements (MREs) manipulate biological processes, such as tumorigenesis. However, only few been reported the pathogenesis of AD. In this study, we constructed first competing RNA (ceRNA) network leveraging...
Alzheimer's disease (AD) is the most common cause of dementia. Amyloid β (Abeta, Aβ) deposition and intracellular tangles are pathological hallmarks AD. MicroRNAs (miRNAs) small non-coding RNAs, which have been found to play very important roles, potential serve as diagnostic markers during neuronal pathogenesis. In this study, we aimed determine roles miR-99b-5p miR-100-5p in Aβ-induced pathologies. We detected expression levels brains APPswe/PS1ΔE9 double-transgenic mice (APP/PS1 mice) at...
MicroRNAs are small non-coding RNAs that repress the expression of their target proteins. The roles microRNAs in development Alzheimer's disease (AD) not clear. In this study we show miR-200c represses PTEN protein. downregulation by supports survival and differentiation cultured neurons. AD is a progressive neurodegenerative signified beta amyloid (Aβ) peptide aggregation deposition. mouse model induced APPswe PS1ΔE9 double transgenes, found Aβ deposition results neuronal ER stress induces...
The aim of this study was to evaluate the outcomes patients with inflammatory breast cancer (IBC), emphasis on role molecular subtypes and radiotherapy.A retrospective cohort investigate overall survival (OS) cancer-specific mortality (BCSM) in IBC conducted using data obtained by Surveillance, Epidemiology, End Results (SEER) program from 2010-2013. Cox multivariate regression used calculate adjusted Hazard Ratios (aHR).403 were eligible for study. Patients group hormone receptors...
With the digestive endoscopic tunnel technique (DETT), many diseases that previously would have been treated by surgery are now endoscopically curable establishing a submucosal between mucosa and muscularis propria (MP). Through tunnel, diagnosis or treatment is performed for lesions in mucosa, MP, even outside gastrointestinal (GI) tract. At present, application range covers following: (1) Treatment of originating from mucosal layer,
Alzheimer's disease (AD) is an age-related irreversible neurodegenerative disorder characterized by extracellular β Amyloid(Aβ) deposition, intracellular neurofibrillary tangles and neuronal loss. The dysfunction of neurogenesis increased degeneration neurons contribute to the pathogenesis AD. We now report that miR-211-5p, a small non-coding RNA, can impair neurite differentiation directly targeting NUAK1, decrease viability accelerate progression Aβ-induced pathologies. In this study, we...
Osteoarthritis (OA), one of the most common motor system disorders, is a degenerative disease involving progressive joint destruction caused by variety factors. At present, OA has become fourth cause disability in world. However, pathogenesis complex and not yet been clarified. Long non-coding RNA (lncRNA) refers to group RNAs more than 200 nucleotides length with limited protein-coding potential, which have wide range biological functions including regulating transcriptional patterns...
Abstract Background Aortic dissection (AD) and aortic aneurysm (AA) are critical illnesses with an unclear pathogenetic mechanism that seriously threaten human life. medial degeneration (AMD) is the main pathological feature of AD AA. Diseases iron metabolism can cause a variety physiological dysfunctions. In this study, we aimed to clarify state in patients AA, explore effect on AMD. Methods A total 200 or 60 hypertension were included study. Blood samples drawn immediately when admitted...
The chronic rejection responses and side effects of the systematic administration immunosuppressants are main obstacles to heart allograft patient survival. development xenotransplantation also urgently requires more efficient immune regulation strategies. Herein, it is demonstrated that lymph-node (LN)-targeted drug delivery can realize LN-specific immunomodulation with attenuated suppression on distant peripheral organs effectively prolong long-term survival after transplantation in a...
Colorectal cancer (CRC) is one of the most common malignancies and characterized by reprogrammed metabolism. Ferroptosis, a programmed cell death dependent on iron, has emerged as promising strategy for CRC treatment. Although small nucleolar RNAs are extensively involved in carcinogenesis, it unclear if they regulate ferroptosis during pathogenesis.The dysregulated snoRNAs were identified using published sequencing data tissues. The expression candidate snoRNAs, host gene target assessed...
Abstract Visual observation and therapeutic intervention against tumors hold significant appeal for tumor treatment, particularly in meeting the demands of intraoperative navigation. From a clinical perspective, naked‐eye visualization provides direct convenient approach to identifying navigating during surgery. Nevertheless, there is an ongoing need develop effective solutions this frontier. Genetically engineered microorganisms are promising as living therapeutics combatting malignant...
Introduction: Image-based diagnostic tools that aid endoscopists to biopsy putative esophageal malignant lesions are essential for ensuring the standardization and quality of Lugol’s chromoendoscopy. But there's no such model available yet. Methods: We developed a using endoscopic Lugol-unstained (LULs) features baseline data from 1099 individuals enrolled large-scale population-based ESCC screening cohort. 603 participants clinical outpatient cohort were included as external validation set....
Abstract BACKGROUND Lily bulbs are used as food and herbal medicine in the Chinese market. These often sulfur‐fumigated during postharvest processing for bleaching preservation. This study aimed to compare volatile compounds non‐fumigation sulfur‐fumigation lily by headspace solid‐phase microextraction (HS‐SPME) coupled with gas chromatography–mass spectrometry (GC–MS) detection multivariate statistical analysis. RESULTS The results showed that sulfur fumigation led chemical transformation...