A5026360653- Transplantation: Methods and Outcomes
- RNA Interference and Gene Delivery
- Renal Transplantation Outcomes and Treatments
- Mitochondrial Function and Pathology
- Aortic Disease and Treatment Approaches
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Aortic aneurysm repair treatments
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Medicinal Plants and Bioactive Compounds
- Advancements in Battery Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Cytomegalovirus and herpesvirus research
- Advanced Battery Technologies Research
- RNA Research and Splicing
- Circular RNAs in diseases
- Dialysis and Renal Disease Management
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- GDF15 and Related Biomarkers
- Advanced battery technologies research
Wuhan University
2021-2023
Renmin Hospital of Wuhan University
2021-2023
The chronic rejection responses and side effects of the systematic administration immunosuppressants are main obstacles to heart allograft patient survival. development xenotransplantation also urgently requires more efficient immune regulation strategies. Herein, it is demonstrated that lymph-node (LN)-targeted drug delivery can realize LN-specific immunomodulation with attenuated suppression on distant peripheral organs effectively prolong long-term survival after transplantation in a...
Abstract Background Aortic dissection (AD) and aortic aneurysm (AA) are critical illnesses with an unclear pathogenetic mechanism that seriously threaten human life. medial degeneration (AMD) is the main pathological feature of AD AA. Diseases iron metabolism can cause a variety physiological dysfunctions. In this study, we aimed to clarify state in patients AA, explore effect on AMD. Methods A total 200 or 60 hypertension were included study. Blood samples drawn immediately when admitted...
Abstract Background Heart transplantation (HT) has been approved as an optimal therapeutic regimen for patients with terminal-stage cardiac failure. However, cold ischaemia‒reperfusion (I/R) injury remains unavoidable and outstanding challenge, which is a major factor in early graft dysfunction obstacle to long-term survival HT. Cold I/R induces by promoting mitochondrial augmenting free radical production inflammatory responses. We therefore designed mitochondrion-targeted nanocarrier...
Iron deficiency (ID) is a global nutritional that was shown to be involved in the pathogenesis of aortic aneurysm and dissection (AAD) our previous studies. Some studies suggested mitochondrial dynamics apoptosis phenotypic transformation vascular smooth muscle cells (VSMCs). However, little known about role medial degeneration (AMD) promoted by an iron deficient diet. The present study investigated effect ID on VSMCs, progression AMD, underlying mechanism. expression p-Drp1 (Ser616) Fis1...
Mangiferin is a naturally occurring xanthone C-glycoside that widely found in various plants. Previous studies have reported mangiferin inhibits tumor cell proliferation and migration. Excessive migration of vascular smooth muscle cells (SMCs) associated with neointimal hyperplasia coronary arteries. However, the role mechanism action still unknown. In this study, mouse carotid artery ligation model was established, primary rat were isolated used for mechanistic assays. We alleviated...
The rate of ribosome biogenesis plays a vital role in cell cycle progression and proliferation is strongly connected with coronary restenosis atherosclerosis. Blocking 1 (BOP1) has been found as an evolutionarily conserved gene pivotal regulator proliferation. However, little known about its neointimal formation relationship vascular smooth muscle (VSMC) migration. present study mainly explores the effect BOP1 on VSMCs, hyperplasia, pathogenic mechanism. expression was to be significantly...
Matrine, an alkaloid derived from traditional Chinese herbs, has been confirmed to regulate immunity and exert anti-inflammatory effects. Matrine injection widely used in clinic therapy for anti-tumor diseases. Heart transplantation(HT) is the only solution end-stage heart failure, but it restricted by cardiac allograft rejection. One of important pathophysiological processes post-transplantation rejection inflammatory cell infiltration. shown a positive protective effect against oxidative...
Heart transplantation (HT) is the only effective treatment for end-stage heart failure because it can effectively improve survival rate and quality of life patients with failure. Artesunate (ART) an artemisinin derivative, good water solubility higher oral bioavailability. The main aim this study was to determine role ART in HT mice.In animal experiments, mice were divided into control group, low ART+HT high group. Next, inflammatory cell infiltration, oxidative stress injury, myocardial...
Despite being the gold-standard treatment for end-stage heart disease, transplantation is associated with acute cardiac rejection within 1 year of transplantation. The continuous application immunosuppressants may cause side effects such as hepatic and renal toxicity, infection, malignancy. Developing new pharmaceutical strategies to alleviate after effectively safely critical importance. In this study, we performed a murine model MHC-full mismatch showed that combination Rhodosin (Rho)...