A5088833841- MicroRNA in disease regulation
- Neural and Behavioral Psychology Studies
- Thyroid Disorders and Treatments
- Muscle Physiology and Disorders
- Neural dynamics and brain function
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- EEG and Brain-Computer Interfaces
- Face Recognition and Perception
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- IoT-based Smart Home Systems
- RNA Interference and Gene Delivery
- Protein Kinase Regulation and GTPase Signaling
- Deception detection and forensic psychology
- Liver Disease Diagnosis and Treatment
- Water Quality Monitoring Technologies
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Context-Aware Activity Recognition Systems
- Eicosanoids and Hypertension Pharmacology
- Adipokines, Inflammation, and Metabolic Diseases
- Arsenic contamination and mitigation
- Mitochondrial Function and Pathology
The University of Queensland
2022-2023
Shanghai Institutes for Biological Sciences
2011-2015
University of Chinese Academy of Sciences
2014-2015
Deleted Institution
2014-2015
Chinese Academy of Sciences
2006-2014
China National Center for Food Safety Risk Assessment
2014
University of Newcastle Australia
2008
Myoblast proliferation following myotrauma is regulated by multiple factors including growth factors, signal pathways, transcription and miRNAs. However, the molecular mechanisms underlying orchestration of these regulatory remain unclear. Here we show that p38 signaling required for miR-1/133a clusters both activity miR-1/133 expression are attenuated during early stage muscle regeneration in various animal models. Additionally, miR-1 miR-133 reduce Cyclin D1 repress myoblast inducing G1...
It is known that thyroid hormone (TH) a major determinant of muscle fiber composition, but the molecular mechanism by which it does so remains unclear. Here, we demonstrated miR-133a1 direct target gene TH in muscle. Intriguingly, miR-133a, enriched fast-twitch muscle, regulates slow-to-fast type conversion targeting TEA domain family member 1 (TEAD1), key regulator slow expression. Inhibition miR-133a vivo abrogated action on conversion. Moreover, TEAD1 overexpression antagonized effect as...
Noninvasive biomarkers with diagnostic value and prognostic applications have long been desired to replace muscle biopsy for Duchenne muscular dystrophy (DMD) patients. Growing evidence indicates that circulating microRNAs are assess pathophysiological status. Here, we show the serum levels of six muscle-specific miRNAs (miR-1/206/133/499/208a/208b, also known as myomiRs) were all elevated in DMD patients (P < 0.01). The receiver operating characteristic curves miR-206, miR-499, miR-208b,...
Abstract Activation of hypoxia-inducible factor 1α (HIF1α) controls the transcription genes governing angiogenesis under hypoxic condition during tumorigenesis. Here we show that hypoxia-responsive miR-182 is regulated by HIF1α at transcriptional level. Prolyl hydroxylase domain enzymes (PHD) and inhibiting HIF-1 (FIH1), negative regulators HIF1 signaling, are direct targets miR-182. Overexpression in prostate cancer cells led to a reduction PHD2 FIH1 expression an increase level either...
The present study shows that arsenic induces GADD45α (growth arrest and DNA damage inducible gene 45α) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial cell line, BEAS-2B, with arsenic(III) chloride (As 3+ ) resulted in a significant increase protein mRNA. However, As only exhibited marginal effect on transcription gene. accumulation mRNA is largely achieved by stabilization cellular response to . able induce binding stabilizing proteins, nucleolin...
Thyroid hormones (THs) are potent modulating liver lipid homeostasis. The perturbation of homeostasis is a hallmark non-alcoholic fatty disease (NAFLD), very common disorder. It was reported that NAFLD patients were associated with higher incidence hypothyroidism. However, whether abnormal thyroid function contributes to the pathogenesis remains unclear.We used in vivo models investigate influence hypothyroidism and TH on hepatic We did not observe triglyceride accumulation hypothyroid mice,...
Due to the development of computer technology and wide use Internet, intelligent appliances with multimedia capability have been emerging into our daily life. Kitchen is one places where such used. Since modern life style driving people spending less time on cooking healthy food at home, an enjoyable can be assisted kitchenware as a smart fridge. In this paper we introduce novel application for fridge capability. It designed managing items stored in it advising its users methods depending...
It has been repeatedly claimed that emotional faces readily capture attention, and they may be processed without awareness. Yet some observations cast doubt on these assertions. Part of the problem lie in experimental paradigms employed. Here, we used a free viewing visual search task during electroencephalographic recordings, where participants searched for either fearful or neutral facial expressions among distractor expressions. Fixation-related potentials were computed targets response...
When searching for a lost item, we tune attention to the known properties of object. Previously, it was believed that is tuned veridical attributes search target (e.g., orange), or an attribute slightly shifted away from irrelevant features towards value can more optimally distinguish distractors red-orange; optimal tuning). However, recent studies showed often relative feature redder), so all items match equally attract redder items; relational account). Optimal tuning shown occur only at...
Abstract It has been repeatedly claimed that emotional faces capture attention readily, and they are processed without awareness. Yet some observations cast doubt on these assertions. Part of the problem may lie in experimental paradigms employed. Here, we used a free viewing visual search task simultaneously recorded electroencephalography eye-movements. Fixation-related potentials were computed for fearful neutral facial expressions, electrical response compared when participants aware or...