A5103007993- Bee Products Chemical Analysis
- Insect and Pesticide Research
- Phytochemicals and Antioxidant Activities
- Gut microbiota and health
- Nematode management and characterization studies
- Natural Products and Biological Research
- Synthesis and Biological Evaluation
- Flavonoids in Medical Research
- Natural Antidiabetic Agents Studies
- Polysaccharides and Plant Cell Walls
- Diet and metabolism studies
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
- Exercise and Physiological Responses
- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
- Metabolism, Diabetes, and Cancer
- Neurogenetic and Muscular Disorders Research
- Phytase and its Applications
- Microencapsulation and Drying Processes
- Ginseng Biological Effects and Applications
- Digestive system and related health
- Burn Injury Management and Outcomes
- Muscle Physiology and Disorders
- Synthesis and Reactivity of Heterocycles
East China University of Science and Technology
2012-2024
National Chung Hsing University
2022
National United University
2020
China Medical University
2020
National Yang Ming Chiao Tung University
2020
Kaohsiung Medical University
2020
China Agricultural University
2017
Natural products with minor side effects have been reported to be an effective adjuvant therapy for glucose and lipid metabolism disorders. Chrysin, a flavone, has wide range of physiological effects, such as antioxidant, anti-inflammatory, anti-diabetes, anti-hyperlipidemia, hepatoprotective. This study was designed explore the mechanism chrysin on metabolic syndrome using insulin-resistant HepG2 cells HFD/STZ-induced C57BL/6J mice. The results indicated that significantly decreased insulin...
Myoblast proliferation following myotrauma is regulated by multiple factors including growth factors, signal pathways, transcription and miRNAs. However, the molecular mechanisms underlying orchestration of these regulatory remain unclear. Here we show that p38 signaling required for miR-1/133a clusters both activity miR-1/133 expression are attenuated during early stage muscle regeneration in various animal models. Additionally, miR-1 miR-133 reduce Cyclin D1 repress myoblast inducing G1...
Caffeic acid phenethyl ester (CAPE), extracted from propolis, was evaluated for the ameliorative effects on insulin resistance and mechanisms were identified, using non-insulin-dependent diabetes mellitus (NIDDM) model mice (IR) cells. After 5 weeks of CAPE supplementation, sensitivity, hyperlipidemia, peroxisome proliferator-activated receptor-α (PPAR-α) levels improved in mice. Proinflammatory cytokines serum expressions tumor necrosis factor-alpha (TNF-α) mRNA tissues markedly...
Abstract Inflammatory bowel disease (IBD) is a chronic intestinal disease, which was commonly found in westerners whereas increasingly prevalent Asia because of the changing eating habits. In previous research, we that water‐soluble polysaccharide isolated from Auricularia auricular‐judae (Bull.) —a kind edible mushroom (Aap)—is composed β‐1,3 glycosidic bonds, regarded as therapeutic or protective substance enteritis. We therefore aimed to find preventing effect Aap on IBD. Here, reported...
Auricularia auricula-judae is an edible fungus with high nutritional value due to abundant polysaccharides, and acknowledged as traditional food medicine in Asia. Polysaccharides from A. auricula (AAPs) are typically fungal polysaccharides have a wide range of biological activities. It has been shown the potential AAPs improve diabetes effective adjuvant, but underlying mechanism remains unclear. In this study, we explored effects on type 2 (T2D) using high-fat diet streptozotocin (STZ)...
Hulless barley starch was extracted and further acetylated using acetic anhydride at different level (3.75, 7.5, 11.25 g/100 g) in this study. The structure changes functional properties of hulless starches comparing to the native were evaluated analyzed. shape granules remained unaltered with cracks formed after modification. Small- (1 μm) large-sized (20 observed four kinds while granule particle sizes distribution changed dramatically. Four presented A-type x-ray diffraction pattern,...
Fipronil, a widely used insecticide and pesticide, with its toxic metabolite fipronil sulfone was detected in fipronil-contaminated eggs as result of inappropriate use. However, little is known about whether transfer into fetus through the blood-placenta barrier. Our objectives were to investigate transplacental pharmacokinetics rats. Male female (with 13 days gestation) Sprague-Dawley rats experiments, respectively. Biologic samples collected at each time point after intravenous or oral...
Octacosanol (Oct), a kind of long-chain fatty alcohol extracted from rice bran was applied to study its effects on alleviating ulcerative colitis (UC). Oct orally administered at 10 mg/kg (Oct-L) and 30 (Oct-H) dextran sulfate sodium (DSS)-induced mice. Here, we reported that oral administration can significantly prevent the weight loss, colon shortening, decrease disease activity index (DAI) score. Oct-H supplementation modified intestinal flora by lowering Firmicutes/Bacteroidetes (F/B)...
A mixture of multiple ingredients is often more effective than the individual ingredients. The functions Lycium barbarum polysaccharide (LBP) glycoconjugate and grape seed procyanidins (GSP) are widely known. Here, we investigated synergistic immune-enhancing activity LBP GSP. Atomic force microscopy results suggested that GSP exhibited circular structure unlike alone, addition polyphenols may change spatial conformation sugar chain. changes in were related to effect two functional agents on...
The quality of canola oil is affected by different extraction methods. effect cold-pressed (CPCO) diet and traditional refined bleached deodorized (RBDCO) on lipid accumulation hepatic steatosis in mice were investigated. body weight, peroxisome proliferator-activated receptor-α concentration, serum profile, insulin sensitivity, oxidative stress increased fed with CPCO diet, which had higher unsaturated fatty acid, tocopherols, phytosterols, phospholipids but lower saturated acid than RBDCO,...
Abstract Nonalcoholic fatty liver disease (NAFLD) is a metabolic syndrome, whose main characteristics are excessive lipid accumulation and oxidative stress. Major royal jelly proteins (MRJPs) kind of water‐soluble protein, which abundant in (RJ). The aim this study was to evaluate the effect MRJPs on stress cells. Here, we first optimized conditions for extracting from RJ identified extraction product by SDS‐PAGE. Then, used oleic acid (OA) 1.0 mM induce hepatocytes 24 hr establish stable...
Diabetic nephropathy (DN) is a highly prevalent and severe diabetic complication. It urgent to explore high efficiency minor side effects therapy for DN. Chrysin natural flavonoid with various biological activities found in honey propolis, has considerable potential improve The study was designed the specific underlying mechanism of chrysin DN high-fat-diet (HFD) streptozotocin (STZ) induced mice. Firstly, revealed that effectively improved obesity, insulin resistance (IR), renal function,...
Nonalcoholic fatty liver disease (NAFLD), the major cause of global chronic hepatic injury, has obtained increasing attention while current drug treatment still laid safety hazards. Major royal jelly proteins (MRJPs), water-soluble enriched in (RJ), were applied to study its effects on improving NAFLD mouse model. Herein, we demonstrated that intaking 250-500 mg/kg/day MRJPs significantly decreased rate obesity, dyslipidemia, steatosis, and insulin resistance. Next, TOF MRM ("TM") widely...
Ten linden honey samples from China and Russia were analyzed in this study. Based on the determination of total polyphenol content (TPC) flavonoid (TFC), antioxidant activities ten analyzed. The results showed that TPC TFC ranged 17.57 to 31.95 mg GAE 100 g-1 0.81 1.77 RE g-1. strongly correlated with capacity, pearson’s correlation values (p≤0.01) 0.828 0.770 respectively. In work, phenolic acids flavonoids by high performance liquid chromatography (HPLC). It was found there a lot lindenin...
With the increasing importance in application of molecular biological detection technology field food safety, strengthening education biology experimental techniques is more necessary for culture students quality and safety major. However, experiments are not always curricula Food Majors. This paper introduced a project "competition among undergraduate sophomore major", participating this needed to learn fundamental such as principles genome extraction, PCR agarose gel electrophoresis...
Abstract Background Complete healing of diabetic wounds continues to be a clinically unmet need. Although robust therapies such as stem cell therapy and growth factor treatment are applied, these treatments costly for most wound patients. Therefore, cheaper alternative is needed. Cobalt protoporphyrin (CoPP) has recently been demonstrated promote tissue regeneration. In this study, the therapeutic benefits CoPP in were examined. Methods An vitro model that mimics re-epithelialization was...
Abstract Octacosanol is a plant natural product with the potential to ameliorate alcoholic liver injury. However, its poor solubility limits application in food industry. This study first verified that octacosanol has favorable effect on acute and subchronic injury mice by protecting gastric mucosa ameliorating disease levels. Additionally, microcapsules were prepared under optimal drying conditions of feed flow rate 400 mL/h temperature 180°C improve ameliorative effects octacosanol,...
A novel procedure for constructing triazepin-8-one skeletons under mild conditions in one pot was developed. The access to triazepin-8-ones achieved via direct amination of imidazol-6-ones with aqueous ammonia and cyclization formaldehyde. experimental simplicity moderate good yields are the main features this method.