A5103053886- Muscle Physiology and Disorders
- Research in Cotton Cultivation
- Adipose Tissue and Metabolism
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Plant and Fungal Interactions Research
- Plant Virus Research Studies
- Mitochondrial Function and Pathology
- Cardiomyopathy and Myosin Studies
- Genetic Neurodegenerative Diseases
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Antibiotic Resistance in Bacteria
- Supramolecular Chemistry and Complexes
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Telomeres, Telomerase, and Senescence
- Plant Molecular Biology Research
- Exercise and Physiological Responses
- Glycogen Storage Diseases and Myoclonus
- Engineering Applied Research
- Congenital Anomalies and Fetal Surgery
- Traditional Chinese Medicine Analysis
- Sirtuins and Resveratrol in Medicine
Children's Hospital of Fudan University
2015-2025
Hubei University of Medicine
2019-2025
Shaanxi University of Science and Technology
2022-2024
Beijing Municipal Ecological and Environmental Monitoring Center
2024
Shanxi Medical University
2022
Shaanxi Provincial People's Hospital
2022
Cotton Research Institute
2016-2021
Chinese Academy of Agricultural Sciences
2018-2021
Zhengzhou University
2019
State Key Laboratory of Cotton Biology
2016-2017
The metabolic regulation of cell death is sophisticated. A growing body evidence suggests the existence multiple checkpoints that dictate fate in response to fluctuations. However, whether microRNAs (miRNAs) are able respond stress, reset threshold death, and attempt reestablish homeostasis largely unknown. Here, we show miR-378/378* KO mice cannot maintain normal muscle weight have poor running performance, which accompanied by impaired autophagy, accumulation abnormal mitochondria,...
Myoblast proliferation following myotrauma is regulated by multiple factors including growth factors, signal pathways, transcription and miRNAs. However, the molecular mechanisms underlying orchestration of these regulatory remain unclear. Here we show that p38 signaling required for miR-1/133a clusters both activity miR-1/133 expression are attenuated during early stage muscle regeneration in various animal models. Additionally, miR-1 miR-133 reduce Cyclin D1 repress myoblast inducing G1...
It is known that thyroid hormone (TH) a major determinant of muscle fiber composition, but the molecular mechanism by which it does so remains unclear. Here, we demonstrated miR-133a1 direct target gene TH in muscle. Intriguingly, miR-133a, enriched fast-twitch muscle, regulates slow-to-fast type conversion targeting TEA domain family member 1 (TEAD1), key regulator slow expression. Inhibition miR-133a vivo abrogated action on conversion. Moreover, TEAD1 overexpression antagonized effect as...
Noninvasive biomarkers with diagnostic value and prognostic applications have long been desired to replace muscle biopsy for Duchenne muscular dystrophy (DMD) patients. Growing evidence indicates that circulating microRNAs are assess pathophysiological status. Here, we show the serum levels of six muscle-specific miRNAs (miR-1/206/133/499/208a/208b, also known as myomiRs) were all elevated in DMD patients (P < 0.01). The receiver operating characteristic curves miR-206, miR-499, miR-208b,...
Understanding the fiber-type specification and metabolic switch in skeletal muscle provides insights into energy metabolism physiology diseases. Here, we show that miR-182 is highly expressed fast-twitch negatively correlates with blood glucose level. knockout mice display loss, fast-to-slow switching, impaired metabolism. Mechanistic studies reveal modulates utilization by targeting FoxO1 PDK4, which control fuel selection via pyruvate dehydrogenase complex (PDHC). Short-term high-fat diet...
Small auxin-up RNA (SAUR) gene family is the largest of early auxin response genes in higher plants, which have been implicated regulation multiple biological processes. However, no comprehensive analysis SAUR has reported cotton (Gossypium spp.).In study, we identified 145, 97, 214, and 176 homologous sequenced genomes G. raimondii, arboreum, hirsutum, barbadense, respectively. A phylogenetic revealed that can be classified into 10 groups. further chromosomal locations duplications showed...
Clinical evidence indicates a close association between muscle dysfunction and bone loss; however, the underlying mechanisms remain unclear. Here, we report that dysfunction–related loss in humans with limb-girdle muscular dystrophy is associated decreased expression of folliculin-interacting protein 1 (FNIP1) tissue. Supporting this finding, murine gain- loss-of-function genetic models demonstrated muscle-specific ablation FNIP1 caused mass, increased osteoclastic activity, mechanical...
This study presents an approach using multiple linear regression to quantify the impact of meteorological parameters and chemical species on aerosol pH variance in urban setting Pearl River Delta, China. Additionally, it assesses contributions interactions among these factors pH. The analysis successfully explains over 96% variance, attributing 85.8% original variables 6.7% bivariate interactions, with further 2.3% 1.0% from trivariate quadrivariate respectively. Our results highlight that...
Cotton (Gossypium spp.) fibers are single-celled elongated trichomes, the molecular aspects of genetic variation in fiber length (FL) among genotypes currently unknown. In this study, two backcross inbred lines (BILs), i.e., NMGA-062 ("Long") and NMGA-105 ("Short") with 32.1 vs. 27.2 mm FL, respectively, were chosen to perform RNA-Seq on developing at 10 days post anthesis (DPA). The BILs differed 4 quantitative trait loci (QTL) for FL developed from backcrosses between G. hirsutum as...
Currently, there is no cure for Duchenne and Becker muscular dystrophies (DMD/BMD). However, clinical trials with new therapeutic strategies are being conducted or considered. A comprehensive database critical patient recruitment efficacy evaluation. China has the largest population, yet, DMD/BMD available. Our study registered data of patients in East China. modified registry form Remudy ( http://www.remudy.jp/ ) was applied to Chinese through outpatient clinic at Children's Hospital Fudan...
The chemotherapy is perplexed by the unsatisfied efficacy due to GSH-induced detoxification. SPSAs reported in this study could not only consume GSH but also reduce biosynthesis pathway, paving a novel way enhance therapeutic efficacy.
Background Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by the loss of dystrophin, which results in inflammation, fibrosis, and inhibition myoblast differentiation skeletal muscle. Catalpol, an iridoid glycoside, improves function enhancing myogenesis; it has potential to treat DMD. We demonstrate positive effects catalpol dystrophic Methods mdx (loss dystrophin) mice ( n = 18 per group) were treated with (200 mg/kg) for six consecutive weeks. Serum analysis,...
Skeletal muscle has a major role in locomotion and disorders are associated with poor regenerative efficiency. Therefore, deeper understanding of regeneration is needed to provide new insight for therapies. CaMKK2 plays the calcium/calmodulin-dependent kinase cascade; however, its skeletal remains unknown. Here, we found that expression levels were altered under physiological pathological conditions including postnatal myogensis, freeze or cardiotoxin-induced regeneration, Duchenne muscular...
Abstract Background Transforming growth factor‐β‐activated kinase 1 (TAK1) plays a key role in regulating fibroblast and myoblast proliferation differentiation. However, the TAK1 changes associated with Duchenne muscular dystrophy (DMD) are poorly understood, it remains unclear how regulation could be exploited to aid treatment of this disease. Methods Muscle biopsies were obtained from control donors or DMD patients for diagnosis ( n = 6 per group, male, 2–3 years, respectively). Protein...
Abstract Background In recent years, immunotherapies and targeted therapies contribute to population-level improvement in NSCLC cancer-specific survival, however, the two novel therapeutic options have mainly benefit patients containing mutated driven genes. Thus, explore other potential genes related with immunity or may provide improve survival of lung cancer without CTSF is unique human cysteine proteinases. Presently, has been detected several cell lines cancer, but its role progression...