A5004326341- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Bone Metabolism and Diseases
- Muscle Physiology and Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metabolism, Diabetes, and Cancer
Children's Hospital of Fudan University
2024
Lovelace Respiratory Research Institute
2017-2022
Biomedical Research Institute
2022
Clinical evidence indicates a close association between muscle dysfunction and bone loss; however, the underlying mechanisms remain unclear. Here, we report that dysfunction–related loss in humans with limb-girdle muscular dystrophy is associated decreased expression of folliculin-interacting protein 1 (FNIP1) tissue. Supporting this finding, murine gain- loss-of-function genetic models demonstrated muscle-specific ablation FNIP1 caused mass, increased osteoclastic activity, mechanical...
Inhalation of aerosolized citric acid (CA) or prostaglandin E2 (PGE2 ) provokes distinct cough patterns (Type I vs. II) and ventilatory responses (substantial hyperventilation slight tachypnea) in humans guinea pigs. Substance P (SP) neurokinin A (NKA) are peripherally released mainly by vagal sensory fibers capable affecting CA-induced response via preferentially activating 1 2 receptors (NK1 R NK2 R) respectively. The goal this study was to determine the impacts CA PGE2 exposure on...