A5034384496- Platelet Disorders and Treatments
- interferon and immune responses
- Immune Response and Inflammation
- Antiplatelet Therapy and Cardiovascular Diseases
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Eicosanoids and Hypertension Pharmacology
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Inflammatory Biomarkers in Disease Prognosis
- Sulfur Compounds in Biology
- Alcohol Consumption and Health Effects
- Caveolin-1 and cellular processes
- Aldose Reductase and Taurine
- Microbial metabolism and enzyme function
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Heparin-Induced Thrombocytopenia and Thrombosis
- Microscopic Colitis
- Renin-Angiotensin System Studies
Soochow University
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Qingdao Agricultural University
2017
Shanghai Jiao Tong University
2007-2013
Fudan University
2012
Ruijin Hospital
2012
Huashan Hospital
2012
The First Affiliated Hospital, Sun Yat-sen University
2012
Zhongshan Hospital
2012
Sun Yat-sen University
2012
The involvement of platelets in tumor progression is well recognized. depletion circulating or pharmacologic inhibitors platelet activation decreases the metastatic potential cells metastasis mouse models. ADP receptor P2Y12 amplifies initial hemostatic responses activated by a variety agonists and stabilizes aggregation, playing crucial role granule secretion, integrin thrombus formation. However, relationship between not clear. In our study, Lewis Lung Carcinoma (LLC) spontaneous model was...
Small ubiquitin-like modifier (SUMO) 2/3 is known to conjugate substrates in response a variety of cellular stresses. However, whether and how SUMO2/3-specific proteases are involved de-conjugation under cell stress unclear. Here, we show that low doses hydrogen peroxide (H(2)O(2)) induce an increase the SENP3 protein, which removes SUMO2/3 from promyelocytic leukemia (PML). Low dose H(2)O(2) causes co-localize with PML bodies reduces number SENP3-dependent manner. Furthermore, responsible...
The aim of the study was to evaluate role purinergic receptor P2Y, G protein-coupled 12 (P2Y12), an ADP receptor, in development atherosclerotic lesions.Apolipoprotein E-null mice were crossed with P2y12(-/-) generate double knockout mice. and control apolipoprotein fed a high-fat diet for 20 weeks. Assessment lesions demonstrated that P2Y12 deficiency caused diminished lesion area, increased fibrous content at plaque site, decreased monocyte/macrophage infiltration lesions. Polymerase chain...
Retinoic acid inducible gene I (RIG-I) senses viral RNAs and triggers innate antiviral responses through induction of type IFNs inflammatory cytokines. However, whether RIG-I interacts with host cellular RNA remains undetermined. Here we report that Rig-I multiple mRNAs, especially Nf-κb1. is required for NF-κB activity via regulating Nf-κb1 expression at posttranscriptional levels. It the binding sites within 3'-UTR mRNA. Further analyses reveal three distinct tandem motifs enriched in...
RIG-I has been implicated in innate immunity by sensing intracellular viral RNAs and inducing type I IFN production. However, we have found a significant induction biological setting without active infection-namely, during RA-induced terminal granulocytic differentiation of acute myeloid leukemias. Here, present evidence that Rig-I also occurs normal myelopoiesis the disruption gene mice leads to development progressive myeloproliferative disorder. The initiation disorder is mainly due an...
We systematically developed a prognostic model for pancreatic cancer that was compatible across different transcriptomic platforms and patient cohorts. After performing quality control measures, we used seven microarray datasets two RNA sequencing to identify consistently dysregulated genes in patients. Weighted gene co-expression network analysis performed explore the associations between expression patterns clinical features. The least absolute shrinkage selection operator (LASSO) Cox...
Protein SUMOylation (SUMO is small ubiquitin-related modifier) a dynamic process that strictly regulated under physiological and pathological conditions. However, little known about how various intra- or extra-cellular stimuli regulate expression levels of components in the SUMO system. isoforms SUMO2 SUMO3 can rapidly convert to be conjugated response variety cellular stresses. Owing limitations sequence homology, cannot differentiated between are thus referred as SUMO2/3. Whether these two...
Integrin αIIbβ3 mediated bidirectional signaling plays a critical role in thrombosis and haemostasis. Signaling by the β3 subunit has been extensively studied, but αIIb not characterized. Previously, we reported that platelet granule secretion TxA2 production induced outside-in is negatively regulated cytoplasmic domain residues R724KEFAKFEEER734. In this study, identified part of pathway utilized signaling. Platelets from humans gene deficient mice, genetically modified CHO cells as well...
This study aimed to construct a predictive model for recurrence and metastasis in patients with localized clear cell renal carcinoma (ccRCC) based on multiple preoperative blood indexes oncological characteristics.Overall, 442 ccRCC between 2013 2015 were included. Using least absolute shrinkage selection operator (LASSO) Cox regression analysis, the top three risk factors from peripheral indicators screened score, prognostic was established. Harrell's concordance index (C-index) applied...
Imprinting disorder during somatic cell nuclear transfer usually leads to the abnormality of cloned animals and low cloning efficiency. However, little is known about role donor imprinting in development embryos. Here, we demonstrated that (H19/Igf2) porcine fetus fibroblasts derived from morphologically abnormal fetuses (the group) was more hypomethylated, accordingly, significantly higher H19 transcription lower Igf2 expression occurred comparison with those normal or control group). When...
Menadione and diquat cause toxicity in isolated hepatocytes. The toxicities of both menadione are primarily due to redox cycling consequent oxidative stress. toxicity, however, has another component as the compound also possesses alkylating oxidating properties allowing it interact directly with cellular nucleophiles. Sulfite afforded considerable protection rat hepatocytes against menadione. This protective effect sulfite may have several components. effectively competed glutathione (GSH)...