A5101815899- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Hydrogels: synthesis, properties, applications
- Cancer, Lipids, and Metabolism
- Neonatal Respiratory Health Research
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Liver Diseases and Immunity
- Asthma and respiratory diseases
- Lung Cancer Research Studies
- Dermatology and Skin Diseases
- Protein Degradation and Inhibitors
- Melanoma and MAPK Pathways
- interferon and immune responses
- PI3K/AKT/mTOR signaling in cancer
- Pancreatitis Pathology and Treatment
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
Sixth Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2019-2024
Soochow University
2022-2024
First Affiliated Hospital of Soochow University
2023-2024
Albert Einstein College of Medicine
2018-2021
Montefiore Medical Center
2021
Michigan Technological University
2017
The engineering of bioadhesives to bind and conform the complex contour tissue surfaces remains a challenge. We have developed novel moldable nanocomposite hydrogel by combining dopamine-modified poly(ethylene glycol) nanosilicate Laponite, without use cytotoxic oxidants. transitioned from reversibly cross-linked network formed dopamine-Laponite interfacial interactions covalently through slow autoxidation cross-linking catechol moieties. Initially, could be remolded different shapes,...
Abstract The engineering of bioadhesives to bind and conform the complex contour tissue surfaces remains a challenge. We have developed novel moldable nanocomposite hydrogel by combining dopamine‐modified poly(ethylene glycol) nanosilicate Laponite, without use cytotoxic oxidants. transitioned from reversibly cross‐linked network formed dopamine–Laponite interfacial interactions covalently through slow autoxidation cross‐linking catechol moieties. Initially, could be remolded different...
Aberrant ubiquitin-proteasome system (UPS) triggers various disorders of biological events and contributes to progression tumorigenesis. The tripartite motif containing 22 (TRIM22) was demonstrated participate in the multiple malignancies. Nevertheless, role TRIM22 melanoma is still indefinite. This project aims investigate function provide novel therapeutical targets.Bioinformatic algorithms were used prognostic significance TRIM22. vitro or vivo assays explore functions melanoma....
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15%-30% of children and 10% adults globally, with its incidence being influenced by genetic, environmental, various other factors. While the immune plays crucial role in development, composition gut microbiota serum metabolites also contribute to pathogenesis.
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer. HCC influenced by sex and multiple metabolic abnormalities. The present study aimed to compare the overall changes between male female patients identify key genes. Metabolic genes pathways were identified based on analyses publicly available data. Differential expression analysis, gene set enrichment survival analysis transcriptional regulation employed explore differences in HCC. results suggested that had more severe...
<title>Abstract</title> Background Autoimmune hepatitis (AIH) is a chronic progressive liver disease. Research indicates high prevalence of insulin resistance among patients with diseases. The triglyceride glucose-body mass index (TyG-BMI index) significantly correlated and serves as reliable surrogate marker for assessment. This study aimed to investigate the relationship between TyG-BMI prognosis in AIH. Methods A total 193 diagnosed AIH at Second Affiliated Hospital Kunming Medical...
Abstract Background: Despite treatment advances, most lung cancer patient will still receive platinum-based chemotherapy and platinum resistance remains a serious clinical problem. RICTOR is key component of the mTOR complex 2. Activation signaling has been suggested to play critical roles in regulating cell migration, invasion metastasis. A recent study indicates that contributes cisplatin human ovarian cells. We hypothesize activation associated with cancer. Thus, we tested sensitivities...