A5036044008- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Peptidase Inhibition and Analysis
- Congenital heart defects research
- Hedgehog Signaling Pathway Studies
- Glycosylation and Glycoproteins Research
- Cardiac tumors and thrombi
- Galectins and Cancer Biology
Soochow University
2017-2023
Zhangjiagang First People's Hospital
2018
Background/Aims: Lymphocyte antigen 6 complex, locus E (LY6E) is a member of the lymphostromal cell membrane Ly6 superfamily protein. The present study investigated clinical significance and potential biological function LY6E in gastric cancer (GC). Methods: mRNA protein expressions human GC tissues cells were tested. Relationship between expression patients’ clinicopathologic characteristics was analyzed. silenced by siRNA cultured cells. Results: RNA microarray profiling assay results...
Background/Aims: Human hedgehog-interacting protein (HHIP) is a negative regulator of the hedgehog (HH) signaling pathway. It deregulated in gastric cancer. The underlying molecular mechanism HHIP-induced inhibition HH remains to be determined. Methods: A lentiviral HHIP expression vector (“LV-HHIP”) was established exogenously over-express cancer cells. and mRNA were tested by Western blotting assay quantitative real-time PCR assay, respectively. Cell survival Counting Kit-8 (CCK-8) assay....
TBX2 is a member of the T box transcription factor family. Its expression and potential biological functions in nasopharyngeal cancer (NPC) cells are studied here. We showed that mRNA protein was significantly elevated multiple human NPC tissues, as compared with adjacent normal tissues. Knockdown by targeted-siRNA inhibited proliferation invasion (CNE-1 HONE-1 lines). Meanwhile, knockdown also induced G1-phase cell cycle arrest. At molecular level, we discovered expressions several tumor...