A5078547424- Genomics and Chromatin Dynamics
- Heat shock proteins research
- RNA Research and Splicing
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- DNA and Nucleic Acid Chemistry
- Chemical Synthesis and Characterization
- Nuclear Structure and Function
- Pluripotent Stem Cells Research
- Reproductive Biology and Fertility
- RNA and protein synthesis mechanisms
- Radioactive element chemistry and processing
- RNA modifications and cancer
- Sperm and Testicular Function
- Anatomy and Medical Technology
- Milk Quality and Mastitis in Dairy Cows
- Spaceflight effects on biology
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Surgical Simulation and Training
- Mechanical Engineering and Vibrations Research
- Vehicle Dynamics and Control Systems
- Medical Imaging Techniques and Applications
- Selenium in Biological Systems
- Subtitles and Audiovisual Media
Massachusetts Institute of Technology
2019-2024
Qingdao Agricultural University
2009-2024
University of Cambridge
2024
Jiangnan University
2023
Sichuan University
1998
The human genome is arranged in the cell nucleus nonrandomly, and phase separation has been proposed as an important driving force for organization. However, active system, contribution of nonequilibrium activities to structure dynamics remains be explored. We simulated using energy function parametrized with chromosome conformation capture (Hi-C) data presence active, nondirectional forces that break detailed balance. found may arise from transcription chromatin remodeling can dramatically...
Scutellaria altissima L. is a common traditional Chinese medicine used to treat inflammation in some countries. Scutellarin, an active major flavone glycoside isolated from the L., has been shown offer various beneficial biochemical effects on cerebrovascular diseases and inflammation. However, antiproliferative of Scutellarin prostate cancer underlying mechanism are not fully elucidated. In present study, we aimed ascertain whether inhibits cell growth further explore molecular mechanism....
Access to adequate anatomical specimens can be an important aspect in learning the anatomy of domestic animals. In this study, authors utilized a structured light scanner and fused deposition modeling (FDM) printer produce highly accurate animal skeletal models. First, various components bovine skeleton, including femur, fifth rib, sixth cervical (C6) vertebra were used digital These then 1:1 scale physical models with FDM printer. The features three‐dimensional (3D) printed compared those...
Abstract Veterinary anatomy plays a crucial role in the curriculum for veterinary medicine and surgery. The integration of modern information technology education can greatly benefit from innovative tools such as augmented reality (AR) applications. aim this study was to develop an accurate interactive three‐dimensional (3D) digital model animal skull using AR technology, aiming enhance learning education. In study, canine specimen isolated, bones were scanned structured light scanner create...
Baicalin, an active flavone isolated from Scutellaria baicalensis Georgi, has been demonstrated to induce various beneficial biochemical effects such as anti‑inflammatory, anti‑viral, and antitumor effects. However, the mechanism of baicalin is not well understood. In present study, was inhibit viability migration a widely used ovarian cancer cell line, A2780, in dose‑dependent manner. MTT assays revealed that significantly decreased cells treated with compared untreated cells, without...
Heat stress stimulates the production of reactive oxygen species (ROS), which cause oxidative damage in kidney. This study clarifies mechanism by saikosaponin-d (SSd), is extracted from roots Bupleurum falcatum L, protects heat-stressed pig kidney proximal tubular (LLC-PK 1 ) cells against damage. SSd alone not cytotoxic at concentrations or 3 μg/mL as demonstrated a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. To assess effects on heat stress-induced cellular...
// Xuexiong Song 1, * , Zhonghua Liu 2, Hongbin He 3, Jianyu Wang 4 Huatao Li 1 Jingyu 2 Fangzheng Zhongling Jiang and Yanjun Huan College of Animal Science Technology, Qingdao Agricultural University, Qingdao, Shandong Province, China Life Science, Northeast Harbin, Heilongjiang 3 Normal Jinan, Institute Chongqing Medical Chongqing, These authors have contributed equally to this work Correspondence to: Huan, email: huanyanjun1982@163.com Keywords: Dnmt1s, DNA methylation reprogramming,...
Nucleosome positioning is crucial for the genome’s function. Though role of DNA sequence in nucleosomes well understood, a detailed mechanistic understanding on impact transcription remains lacking. Using numerical simulations, we investigated dependence nucleosome density profiles level across multiple species. We found that low affinity yeast, but not mouse, promoters contributes to formation phased arrays inactive genes. For active genes, heterogeneous distribution +1 nucleosomes, caused...
The synthesis of β-trifluoromethylthiolation enamines and enamides was realized involving an EDA photochemistry strategy.
Metritis is a frequently occurring diseases in postpartum cows and one of the important reasons for infertility dairy cows, accounting 20-30% cow has serious implications industry. It been reported literature that bacterial balance genital tracts directly related to maintenance physiological function development various reproductive system. By analyzing changes abundance diversity bacteria uterus from 1 35 days postpartum, objective was reveal mechanism metritis provide basis diagnosis,...
Nucleosome positioning controls the accessible regions of chromatin and plays essential roles in DNA-templated processes. ATP driven remodeling enzymes are known to be crucial for its establishment vivo, but their nonequilibrium nature has hindered development a unified theoretical framework nucleosome positioning. Using perturbation theory, we show that effect these can well approximated by effective equilibrium models with rescaled temperatures interactions. Numerical simulations support...
Scutellaria baicalensis has been effectively used in Chinese traditional medicine to prevent miscarriages. However, little information is available on its mechanism of action. This study designed specifically reveal how baicalin, the main effective ingredient S. baicalensis, improves developmental competence embryos vitro, using mouse as a model. Mouse pronuclear were cultured KSOM medium supplemented with (0, 2, 4 and 8 μg/ml) baicalin. The results demonstrated that vitro culture conditions...
The intricate structural organization of the human nucleus is fundamental to cellular function and gene regulation. Recent advancements in experimental techniques, including high-throughput sequencing microscopy, have provided valuable insights into nuclear organization. Computational modeling has played significant roles interpreting observations by reconstructing high-resolution ensembles uncovering principles. However, absence standardized tools poses challenges for furthering...
The intricate structural organization of the human nucleus is fundamental to cellular function and gene regulation. Recent advancements in experimental techniques, including high-throughput sequencing microscopy, have provided valuable insights into nuclear organization. Computational modeling has played significant roles interpreting observations by reconstructing high-resolution ensembles uncovering principles. However, absence standardized tools poses challenges for furthering...
The intricate structural organization of the human nucleus is fundamental to cellular function and gene regulation. Recent advancements in experimental techniques, including high-throughput sequencing microscopy, have provided valuable insights into nuclear organization. Computational modeling has played significant roles interpreting observations by reconstructing high-resolution ensembles uncovering principles. However, absence standardized tools poses challenges for furthering...
Imprinting disorder during somatic cell nuclear transfer usually leads to the abnormality of cloned animals and low cloning efficiency. However, little is known about role donor imprinting in development embryos. Here, we demonstrated that (H19/Igf2) porcine fetus fibroblasts derived from morphologically abnormal fetuses (the group) was more hypomethylated, accordingly, significantly higher H19 transcription lower Igf2 expression occurred comparison with those normal or control group). When...