A5035663959- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antiplatelet Therapy and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Viral Infections and Immunology Research
- Nutritional Studies and Diet
- Atherosclerosis and Cardiovascular Diseases
- Ion channel regulation and function
- Nuclear Receptors and Signaling
- Climate Change and Health Impacts
- Venous Thromboembolism Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver physiology and pathology
- Diabetes Management and Research
- Genetic Associations and Epidemiology
- Acute Kidney Injury Research
- Extracellular vesicles in disease
Huashan Hospital
2014-2024
Fudan University
2014-2024
Third Affiliated Hospital of Sun Yat-sen University
2023-2024
Sun Yat-sen University
2012-2024
China Pharmaceutical University
2020-2024
Shenzhen University
2010-2023
Yunnan Academy of Agricultural Sciences
2023
Shenzhen University Health Science Center
2016-2022
Nanjing Drum Tower Hospital
2022
Wenzhou Medical University
2017
Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but normal-weight people. However, we have limited knowledge how to prevent T2DM We aimed evaluate the association between triglyceride glucose (TyG) index and incident among people rural China.We included data from 5706 with normal body mass (BMI) (18.5-23.9 kg/m2) without baseline a Chinese cohort followed for median 6.0 years. A Cox proportional-hazard model was used assess risk by quartiles TyG difference...
PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver and released into blood, elevates plasma low-density lipoprotein cholesterol degrading receptor. Pleiotropic effects of beyond lipid metabolism have been shown. However, direct on platelet activation thrombosis, underlying mechanisms, as well, still remain unclear.We detected agonist-induced aggregation, dense granule ATP release, integrin αIIbβ3 activation, α-granule spreading, clot retraction. These studies were...
Background: Platelets from patients with diabetes mellitus are hyperactive. Hyperactivated platelets may contribute to cardiovascular complications and inadequate responses antiplatelet agents in the setting of mellitus. However, underlying mechanism hyperactivated is not completely understood. Methods: We measured P2Y 12 expression on type 2 rats also assayed platelet activation by measuring cAMP VASP phosphorylation. The antithrombotic effects AR-C78511 cangrelor were compared rats....
The aim of the study was to evaluate role purinergic receptor P2Y, G protein-coupled 12 (P2Y12), an ADP receptor, in development atherosclerotic lesions.Apolipoprotein E-null mice were crossed with P2y12(-/-) generate double knockout mice. and control apolipoprotein fed a high-fat diet for 20 weeks. Assessment lesions demonstrated that P2Y12 deficiency caused diminished lesion area, increased fibrous content at plaque site, decreased monocyte/macrophage infiltration lesions. Polymerase chain...
Mitochondrial DNA (mtDNA), acting as a newly found 'danger-associated molecular patterns' (DAMPs), is released into circulation upon tissue injury and performs considerable activator of inflammation immune response. However, the role circulating mtDNA in experimental autoimmune myocarditis (EAM) well Toll like receptor4 (TLR4) mediated cardiac remains unknown.A model EAM was established BALB/c mice by immunization with porcine myosin. Lipopolysaccharide (LPS) used to stimulate TLR4...
<h3>Objective</h3> The risk of incident hypertension with gain in waist circumference (WC) has not been fully addressed among Chinese adults. <h3>Methods</h3> A total 10 265 non-hypertensive participants ≥18 years old who underwent health examinations rural China were recruited 2007–2008 and followed up 2013–2014. Participants classified by gender according to categories per cent WC at follow-up: ≤−2.5%, −2.5% 2.5%, 2.5% 5% >5%. Relative (RR) 95% CI values for effect on the calculated...
IL-37 (interleukin-37), a natural suppressor of innate inflammatory and immune responses, is increased in patients with myocardial infarction. Platelets play an important role the progress infarction, but direct effects on platelet activation thrombosis, as well underlying mechanisms, still remain unclear.We evaluated agonists-induced thrombus formation, revealed mechanisms using platelet-specific IL-1R8 (IL-1 receptor 8)-deficient mice. Using infarct model, we explored microvascular...
Diabetes is well recognized to increase the risk of heart failure, which associated with higher mortality and morbidity. It important for development novel therapeutic methods targeting failure in diabetic patients. Ferroptosis, an iron-dependent regulated cell death, has been implicated progression diabetes-induced (DIHF). This study was designed investigate contribution Nr2f2 activation ferroptosis mitochondrial dysfunction DIHF. We established a model by high-fat feeding diet combined...
Mitochondrial dynamic imbalance associates with several cardiovascular diseases. However, the role of mitochondrial dynamics in TLR4 activation-mediated dilated cardiomyopathy (DCM) progress remains unknown. A model experimental autoimmune myocarditis (EAM) was established BALB/c mice on which activation by LPS-EB or inhibition LPS-RS performed to induce chronic inflammation for 5 weeks. promoted transition EAM DCM as demonstrated increased cardiomyocyte apoptosis, myocardial fibrosis,...
Abstract To compare the ability of a body shape index (ABSI) and adiposity estimator (BAE) to BMI, waist circumference (WC) waist:height ratio (WHtR) for predicting development type 2 diabetes mellitus (T2DM) in rural adult Chinese. The prospective cohort study included 11 687 eligible participants who were free T2DM at baseline. risk new-onset ABSI, BAE, WC WHtR quintiles was estimated by Cox proportional-hazards regression follow-up. We also compared power ABSI BAE T2DM. With increasing...
Abstract Aims/Introduction To clarify the association of hypertriglyceridemic waist phenotype and type 2 diabetes mellitus among adults in China. Materials Methods In present case–control study, we included 1,685 patients with 7,141 normal glucose‐tolerant controls from Henan Province China 2011. Elevated circumference ( GW ) was defined as ≥90 cm for men ≥80 women. Hypertriglyceridemia HT >1.7 m mol/L triglycerides TG level. The investigated by sex, body mass index, physical activity,...
Diabetic cardiomyopathy (DCM), a serious complication of diabetes, leads to structural and functional abnormalities the heart ultimately evolves failure. IL-37 exerts substantial influence on regulation inflammation metabolism. Whether is involved in DCM unknown.