A5078744224- MicroRNA in disease regulation
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Flavonoids in Medical Research
- Platelet Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Credit Risk and Financial Regulations
- Bioactive natural compounds
- Cancer Mechanisms and Therapy
- Blood Coagulation and Thrombosis Mechanisms
- Cell death mechanisms and regulation
- Corporate Finance and Governance
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Coronary Artery Anomalies
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Agriculture and Biological Studies
- Frailty in Older Adults
Huashan Hospital
2020-2025
Fudan University
1994-2025
Ningbo University
2023-2024
State Key Laboratory of Natural Medicine
2018-2019
China Pharmaceutical University
2018-2019
Ministry of Education of the People's Republic of China
2015
International Space Science Institute - Beijing
1997
Abstract Background Circular RNAs (circRNAs), one of the major contents exosomes, have been shown to participate in occurrence and progression cancers. The role diagnostic potential exosome-transported circRNAs non-small-cell lung cancer (NSCLC) remain largely unknown. Methods NSCLC-associated exosomal circ_0061407 circ_0008103 were screened by circRNA microarray. NSCLC was examined vitro vivo. encapsulation two into exosomes transport recipient cells observed confocal microscopy. effects on...
Abstract Background Extracellular vesicles (EVs) participate in cancer development via cell-to-cell communication. Long non-coding RNAs (lncRNAs), one component of EVs, can play an essential role non-small-cell lung (NSCLC) through EV-mediated delivery. Methods The NSCLC-associated lncRNA AL139294.1 EVs was identified microarray analysis. NSCLC examined vitro and vivo. Confocal microscopy used to observe the encapsulation into its transport recipient cells. A co-culture device examine...
IL-37 (interleukin-37), a natural suppressor of innate inflammatory and immune responses, is increased in patients with myocardial infarction. Platelets play an important role the progress infarction, but direct effects on platelet activation thrombosis, as well underlying mechanisms, still remain unclear.We evaluated agonists-induced thrombus formation, revealed mechanisms using platelet-specific IL-1R8 (IL-1 receptor 8)-deficient mice. Using infarct model, we explored microvascular...
Abstract Background Cilostazol combined with P2Y 12 receptor inhibitor has been used as a substitute regimen for aspirin‐intolerant patients undergoing percutaneous coronary stent implantation on small scale. Its exact impact platelet functions and clinical benefits of is unknown. Hypothesis inhibitors could be antiplatelet implantation. Methods In this multicenter prospective cohort trial, elective were assigned to the cilostazol group (cilostazol plus inhibitors), based aspirin intolerance...
Abstract Backgrounds 20-30% atrial fibrillation (AF) may result in heart failure (HF). Noninvasive left ventricle myocardial work (LVMW) is a fairly new method for detecting LV function. We aimed to evaluate whether LVMW could detect the change function paroxysmal (PAF) and predict HF incident. Methods In this prospective cohort study, 146 PAF subjects 63 non-PAF matched by age gender set as controls were enrolled. parameters, including global index, constructive work, wasted (GWW)...