A5101571870- Genomics and Chromatin Dynamics
- Advanced Fluorescence Microscopy Techniques
- Bacterial Genetics and Biotechnology
- Epigenetics and DNA Methylation
- Topic Modeling
- Multimodal Machine Learning Applications
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Cancer-related molecular mechanisms research
- Pesticide and Herbicide Environmental Studies
- RNA modifications and cancer
- Circular RNAs in diseases
- Natural Language Processing Techniques
- Gene Regulatory Network Analysis
- Single-cell and spatial transcriptomics
- Extracellular vesicles in disease
- Metabolomics and Mass Spectrometry Studies
- Advanced Image and Video Retrieval Techniques
- Nuclear Structure and Function
- Pharmaceutical and Antibiotic Environmental Impacts
- Agriculture, Soil, Plant Science
- Advanced Graph Neural Networks
- Digital Storytelling and Education
Ningbo University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Ningbo University Affiliated Hospital
2024
University of Michigan
2018-2024
Beijing Radiation Center
2024
University of Science and Technology Beijing
2024
South China Normal University
2024
Hubei University of Technology
2024
University of California, Berkeley
2024
Guangdong University of Technology
2023
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by accumulation of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein. Accumulating evidence has revealed that slow progressive deterioration AD associated with oxidative stress chronic inflammation in brain. Nuclear factor erythroid 2- (NF-E2-) related 2 (Nrf2), which acts through Nrf2/ARE pathway, a key regulator antioxidant anti-inflammatory response. Although recent data show link between Nrf2...
Polyphosphate specifically cooperates with Hfq to silence prophages and mobile genetic elements in the bacterial chromosome.
Abstract Background Circular RNAs (circRNAs), one of the major contents exosomes, have been shown to participate in occurrence and progression cancers. The role diagnostic potential exosome-transported circRNAs non-small-cell lung cancer (NSCLC) remain largely unknown. Methods NSCLC-associated exosomal circ_0061407 circ_0008103 were screened by circRNA microarray. NSCLC was examined vitro vivo. encapsulation two into exosomes transport recipient cells observed confocal microscopy. effects on...
Abstract Background Extracellular vesicles (EVs) participate in cancer development via cell-to-cell communication. Long non-coding RNAs (lncRNAs), one component of EVs, can play an essential role non-small-cell lung (NSCLC) through EV-mediated delivery. Methods The NSCLC-associated lncRNA AL139294.1 EVs was identified microarray analysis. NSCLC examined vitro and vivo. Confocal microscopy used to observe the encapsulation into its transport recipient cells. A co-culture device examine...
Biomolecular condensates have emerged as major drivers of cellular organization. It remains largely unexplored, however, whether these can impart mechanical function(s) to the cell. The heterochromatin protein HP1α (Swi6 in Schizosaccharomyces pombe) crosslinks histone H3K9 methylated nucleosomes and has been proposed undergo condensation drive liquid-like clustering domains. Here, we leverage genetically tractable S. pombe model a separation-of-function allele elucidate function imparted by...
Radiation-induced enteritis is an unavoidable complication associated with pelvic tumor radiotherapy, significantly influencing the prognosis of cancer patients. The limited availability commercial gastrointestinal radioprotectors in clinical settings poses a substantial challenge preventing radiation enteritis. Despite inherent radioprotective characteristics Cur vitro, its poor solubility water, instability, and low bioavailability lead to inferior therapeutic effects vivo. Herein, we...
In relation extraction for knowledge-based question answering, searching from one entity to another via a single is called "one hop". related work, an exhaustive search all one-hop relations, two-hop and so on the max-hop relations in knowledge graph necessary but expensive. Therefore, number of hops generally restricted two or three. this paper, we propose UHop, unrestricted-hop framework which relaxes restriction by use transition-based replace relation-chain-based one. We conduct...
Stories are diverse and highly personalized, resulting in a large possible output space for story generation. Existing end-to-end approaches produce monotonous stories because they limited to the vocabulary knowledge single training dataset. This paper introduces KG-Story, three-stage framework that allows generation model take advantage of external Knowledge Graphs interesting stories. KG-Story distills set representative words from input prompts, enriches word by using graphs, finally...
HP1 proteins traverse a complex and crowded chromatin landscape to bind with low affinity but high specificity histone H3K9 methylation (H3K9me) form transcriptionally inactive genomic compartments called heterochromatin. Here, we visualize single-molecule dynamics of an homolog, the fission yeast Swi6, in its native environment. By tracking single Swi6 molecules, identify mobility states that map discrete biochemical intermediates. Using mutants perturb H3K9me recognition, oligomerization,...
Modern foundation models often undergo iterative ``bootstrapping'' in their post-training phase: a model generates synthetic data, an external verifier filters out low-quality samples, and the high-quality subset is used for further fine-tuning. Over multiple iterations, model's performance improves--raising crucial question: how should total budget on generation training be allocated across iterations to maximize final performance? In this work, we develop theoretical framework analyze...
Lung cancer has a notably high incidence and mortality rate, understanding its occurrence development is crucial for effective treatment. Circular RNA closely associated with tumor progression, playing role in tumorigenesis by regulating gene expression influencing cell proliferation apoptosis. This study aims to explore the circFOXK2 NSCLC elucidate underlying mechanisms. qRT-PCR Western Blot analyzed expressions of circFOXK2, STMN1, PABPCA lines, as well their relationships. The roles...
Zi-Yuan Chen, Chih-Hung Chang, Yi-Pei Jijnasa Nayak, Lun-Wei Ku. Proceedings of the 2019 Conference North American Chapter Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long and Short Papers). 2019.
Single particle tracking (SPT) enables the investigation of biomolecular dynamics at a high temporal and spatial resolution in living cells, analysis these SPT datasets can reveal biochemical interactions mechanisms. Still, how to make best use data for broad set experimental conditions remains an challenge field. Here, we develop new framework: NOBIAS (NOnparametric Bayesian Inference Anomalous Diffusion Single-Molecule Tracking), which applies nonparametric statistics deep learning...
Identifying crop disease fast, intelligently and accurately, plays a vital role in agricultural informatization development, while existing methods are almost performed manually, which depends on expert experience, thus the identifying result is inevitably influenced by personal preferences. To address these issues, an improved identification method based convolutional neural network proposed to process images of crops for diseases. Firstly, original were cut normalized, irrelevant noises...
Bacterial DNA methyltransferases (MTases) function in restriction modification systems, cell cycle control, and the regulation of gene expression. DnmA is a recently described MTase that forms N6-methyladenosine at nonpalindromic 5'-GACG
In our survey in the copper (Cu) mining area of China, a sun fern (Pteridium revolutum) was found to accumulate 30-567 mg Cu kg(-1) DW (33 samples) its fronds with large frond biomass. translocation factors plants varied from 0.09 3.88. greenhouse pot experiment, effect an elevated CO2 concentration (700 microL L(-1)) on accumulation studied using three species (P. revolutum, Pteridium aquilinum, and Pteris vittata) grown Cu-contaminated soil. P. revolutum showed higher tolerance but factor...
Abstract HP1 proteins are essential for establishing and maintaining transcriptionally silent heterochromatin. They dimerize, forming a binding interface to recruit diverse chromatin-associated factors. Although known rapidly evolve, the extent of variation required achieve functional specialization is unknown. To investigate how changes in amino acid sequence impacts heterochromatin formation, we performed targeted mutagenesis screen S. pombe homolog, Swi6. Substitutions within an auxiliary...